Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Min Jeong Kye"'
Autor:
Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um, Wootae Ha, Soo Min Lee, Junseong Park, Min Jeong Kye, Jungyo Suh, Jin Woo Choi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background Recent intravesical administration of adenoviral vectors, either as a single injection or in combination with immune checkpoint inhibitors, exemplified by cretostimogene grenadenorepvec and nadofaragene firadenovec, has demonstrat
Externí odkaz:
https://doaj.org/article/82cfd578020d4122be752f044b76e28f
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of lower motor neurons, which leads to proximal muscle weakness and atrophy. SMA is caused by reduced survival motor neuron (SMN) protein levels due to biallelic
Externí odkaz:
https://doaj.org/article/0912fb4d48f64c758bca9539ceb175fd
Autor:
Wiebke A. Rehorst, Maximilian P. Thelen, Hendrik Nolte, Clara Türk, Sebahattin Cirak, Jonathan M. Peterson, G. William Wong, Brunhilde Wirth, Marcus Krüger, Dominic Winter, Min Jeong Kye
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder, which causes dysfunction/loss of lower motor neurons and muscle weakness as well as atrophy. While SMA is primarily considered as a motor neuron disease, recent data sugge
Externí odkaz:
https://doaj.org/article/3a45f28b932f4b949072050c3401599a
Autor:
Maximilian Paul Thelen, Min Jeong Kye
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2020)
As neurons are one of the most highly polarized cells in our body, they require sophisticated cellular mechanisms to maintain protein homeostasis in their subcellular compartments such as axons and dendrites. When neuronal protein homeostasis is dist
Externí odkaz:
https://doaj.org/article/a5ca1c7d6de44b45a5124ae35085c697
Autor:
Eva Janzen, Lisa Wolff, Natalia Mendoza-Ferreira, Kristina Hupperich, Andrea Delle Vedove, Seyyedmohsen Hosseinibarkooie, Min Jeong Kye, Brunhilde Wirth
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Many neurodegenerative disorders share common pathogenic pathways such as endocytic defects, Ca2+ misregulation and defects in actin dynamics. Factors acting on these shared pathways are highly interesting as a therapeutic target. Plastin 3 (PLS3), a
Externí odkaz:
https://doaj.org/article/65c3660dc28c4f03babf89ef4c4949db
Autor:
Aaradhita Upadhyay, Seyyedmohsen Hosseinibarkooie, Svenja Schneider, Anna Kaczmarek, Laura Torres-Benito, Natalia Mendoza-Ferreira, Melina Overhoff, Roman Rombo, Vanessa Grysko, Min Jeong Kye, Natalia L. Kononenko, Brunhilde Wirth
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Neurocalcin delta (NCALD) is a brain-enriched neuronal calcium sensor and its reduction acts protective against spinal muscular atrophy (SMA). However, the physiological function of NCALD and implications of NCALD reduction are still elusive. Here, w
Externí odkaz:
https://doaj.org/article/35272ecbff7c41e6b8cfd4fe658f58e1
Autor:
Patrick J O'Hern, Inês do Carmo G. Gonçalves, Johanna Brecht, Eduardo Javier López Soto, Jonah Simon, Natalie Chapkis, Diane Lipscombe, Min Jeong Kye, Anne C Hart
Publikováno v:
eLife, Vol 6 (2017)
Spinal Muscular Atrophy (SMA) is caused by diminished Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction (NMJ) dysfunction and spinal motor neuron (MN) loss. Here, we report that reduced SMN function impacts the action of a per
Externí odkaz:
https://doaj.org/article/fdd6095295904033b37f7e73f69d3f46
Autor:
Min Jeong Kye, Pierre Neveu, Yong-Seok Lee, Miou Zhou, Judith A Steen, Mustafa Sahin, Kenneth S Kosik, Alcino J Silva
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24682 (2011)
We measured the expression of 187 miRNAs using quantitative real time PCR in the hippocampal CA1 region of contextually conditioned mice and cultured embryonic rat hippocampal neurons after neuronal stimulation with either NMDA or bicuculline. Many o
Externí odkaz:
https://doaj.org/article/c462154699d6496a8bccbeeece78e90d
Autor:
A. Negrete-Hurtado, E. De Bruyckere, Min Jeong Kye, Melina Overhoff, Ines Neundorf, Vangelis Kondylis, K. Schätzmüller, Michael Lammers, Sujoy Bera, C. Qin, Natalia L. Kononenko
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
Neurons maintain axonal homeostasis via employing a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Abnormal MT-based trafficking hallmarks the pathology of n
Publikováno v:
Annual review of genomics and human genetics. 21
Twenty-five years ago, the underlying genetic cause for one of the most common and devastating inherited diseases in humans, spinal muscular atrophy (SMA), was identified. Homozygous deletions or, rarely, subtle mutations of SMN1 cause SMA, and the c