Zobrazeno 1 - 10
of 608
pro vyhledávání: '"Min Goo Lee"'
Autor:
Jihoon G. Yoon, Dong Geon Jang, Sung-Gyu Cho, Chaeyoung Lee, Shin Hye Noh, Soo Kyung Seo, Jung Woo Yu, Hyeon Woo Chung, KyeoRe Han, Soon Sung Kwon, Dai Hoon Han, Jaeseong Oh, In-Jin Jang, Sang-Hoon Kim, Young-Koo Jee, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Chul Hoon Kim, Jae Myun Lee, Sang-Heon Kim, Min Goo Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 3, Pp 570-582 (2024)
Abstract Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that may increase the susceptibility
Externí odkaz:
https://doaj.org/article/119002dbb031472bbb9999dad2b2d002
Autor:
Jinsei Jung, Shin Hye Noh, Sungwoo Jo, Doona Song, Min Jin Kang, Mi Hwa Shin, Hyun Jae Lee, Jae-Chul Pyun, Wan Namkung, Gyoonhee Han, Min Goo Lee, Jae Young Choi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115445- (2023)
Variants in SLC26A4 (pendrin) are the most common reasons for genetic hearing loss and vestibular dysfunction in East Asians. In patients with Pendred syndrome and DFNB4 (autosomal recessive type of genetic hearing loss 4), caused by variants in SLC2
Externí odkaz:
https://doaj.org/article/4959a1ba140a46e0a84a1435d1f205d7
Autor:
Dong Yun Kim, Yu Jin Sub, Hye-Youn Kim, Kyeong Jee Cho, Won Il Choi, Yo Jun Choi, Min Goo Lee, Friedhelm Hildebrandt, Heon Yung Gee
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background LRRC6 is an assembly factor for dynein arms in the cytoplasm of motile ciliated cells, and when mutated, dynein arm components remained in the cytoplasm. Here, we demonstrate the role of LRRC6 in the active nuclear translocation o
Externí odkaz:
https://doaj.org/article/12d278c2f9ae4adf8b677f55832bb75b
Autor:
Hak Park, Soo Kyung Seo, Ju‐Ri Sim, Su Jin Hwang, Ye Jin Kim, Dong Hoon Shin, Dong Geon Jang, Shin Hye Noh, Pil‐Gu Park, Si Hwan Ko, Mi Hwa Shin, Jae Young Choi, Yukishige Ito, Chung‐Min Kang, Jae Myun Lee, Min Goo Lee
Publikováno v:
Advanced Science, Vol 9, Iss 24, Pp n/a-n/a (2022)
Abstract Under ER stress conditions, the ER form of transmembrane proteins can reach the plasma membrane via a Golgi‐independent unconventional protein secretion (UPS) pathway. However, the targeting mechanisms of membrane proteins for UPS are unkn
Externí odkaz:
https://doaj.org/article/845710aaf9e4462cb9a249f7df007897
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cellular proteins directed to the plasma membrane or released into the extracellular space can undergo a number of different pathways. Whereas the molecular mechanisms that underlie conventional ER-to-Golgi trafficking are well established, those ass
Externí odkaz:
https://doaj.org/article/e35532c395de46fb9688d146cdc203e8
Autor:
Hye Ji Choi, Hyun Jae Lee, Jin Young Choi, Ik Hyun Jeon, Byunghwa Noh, Sushil Devkota, Han-Woong Lee, Seong Kug Eo, Jae Young Choi, Min Goo Lee, Jinsei Jung
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 188-197 (2020)
The His723Arg (H723R) mutation in SLC26A4, encoding pendrin, is the most prevalent mutation in East Asia, resulting in DFNB4, an autosomal recessive type of genetic hearing loss. Although the main pathological mechanism of H723R was identified as a p
Externí odkaz:
https://doaj.org/article/03023b2578ba4536a741af8aa7224e62
Autor:
Jiyoon Kim, Hyeyon Kim, Shin Hye Noh, Dong Geon Jang, Shi-Young Park, Dongkook Min, Hyunki Kim, Hee-Seok Kweon, Hoguen Kim, Sowon Aum, Sookyung Seo, Cheol Soo Choi, Hail Kim, Jae Woo Kim, Seok Jun Moon, Heon Yung Gee, Min Goo Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The physiological roles of the Golgi reassembly-stacking protein 55 (GRASP55/GORASP55) remain largely elusive. Here, the authors show that the Golgi-resident protein GRASP55 plays a crucial role in lipid homeostasis by regulating intestinal lipid upt
Externí odkaz:
https://doaj.org/article/cf1efe464e0048bcb1c2c89a7f1a6032
Autor:
Mengnan Li, Shin-ya Nishio, Chie Naruse, Meghan Riddell, Sabrina Sapski, Tatsuya Katsuno, Takao Hikita, Fatemeh Mizapourshafiyi, Fiona M. Smith, Leanne T. Cooper, Min Goo Lee, Masahide Asano, Thomas Boettger, Marcus Krueger, Astrid Wietelmann, Johannes Graumann, Bryan W. Day, Andrew W. Boyd, Stefan Offermanns, Shin-ichiro Kitajiri, Shin-ichi Usami, Masanori Nakayama
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
While biallelic mutations of the SLC26A4 gene cause non-syndromic hearing loss with enlarged vestibular aqueducts or Pendred syndrome, a considerable number of patients carry mono-allelic mutations. Here the authors identify EPHA2 as another causativ
Externí odkaz:
https://doaj.org/article/2394b397faac4471be86a22fa110d8db
Autor:
Yonjung Kim, Ikhyun Jun, Dong Hoon Shin, Jihoon G. Yoon, He Piao, Jinsei Jung, Hyun Woo Park, Mary Hongying Cheng, Ivet Bahar, David C. Whitcomb, Min Goo Lee
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 79-103 (2020)
Backgraoud & Aims: Aberrant epithelial bicarbonate (HCO3−) secretion caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is associated with several diseases including cystic fibrosis and pancreatitis. Dynamica
Externí odkaz:
https://doaj.org/article/c6eb1ab64573444889221934c2ae218e
Autor:
Byeongjun Lee, Gyu-Sang Hong, Sung Hoon Lee, Hyungsup Kim, Ajung Kim, Eun Mi Hwang, Jiyoon Kim, Min Goo Lee, Jin-Young Yang, Mi-Na Kweon, Chung-Ming Tse, Donowitz Mark, Uhtaek Oh
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 8, Pp 1-14 (2019)
Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine. Uhtaek Oh
Externí odkaz:
https://doaj.org/article/4e7c30ad99eb4d6397d3b848cfed433e