Muscle Injuries Induce a Prostacyclin‐PPARγ/PGC1a‐FAO Spike That Boosts Regeneration

Autor: Lanfang Luo, Yan‐Jiang Benjamin Chua, Taoyan Liu, Kun Liang, Min‐Wen Jason Chua, Wenwu Ma, Jun‐Wei Goh, Yuefan Wang, Jiali Su, Ying Swan Ho, Chun‐Wei Li, Ke Hui Liu, Bin Tean Teh, Kang Yu, Ng Shyh‐Chang

Publikováno v: Advanced Science, Vol 10, Iss 21, Pp n/a-n/a (2023)

Abstract It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are both known to induce muscle regeneration, the molecular signals that help trigg

Externí odkaz: https://doaj.org/article/daad7b1142a446e7a5b8ec6dee2ed92d

Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state

Autor: Peng Wang, Xupeng Liu, Ziyue Yao, Yu Chen, Lanfang Luo, Kun Liang, Jun-Hao Elwin Tan, Min-Wen Jason Chua, Yan-Jiang Benjamin Chua, Shilin Ma, Liping Zhang, Wenwu Ma, Shuqing Liu, Wenhua Cao, Luyao Guo, Lu Guang, Yuefan Wang, He Zhao, Na Ai, Yun Li, Chunwei Li, Ruiqi Rachel Wang, Bin Tean Teh, Lan Jiang, Kang Yu, Ng Shyh-Chang

Publikováno v: Cell Research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c845041d8447a9e75953c2814ca12f48
https://doi.org/10.1038/s41422-023-00818-y

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

Autor: Chunwei Li, Kang Yu, Wenhua Cao, Yan-Jiang Benjamin Chua, Min-Wen Jason Chua, Peng Wang, Bin Tean Teh, Jiali Su, Lanfang Luo, Yu Chen, Shilin Ma, Ruirui Liu, Lan Jiang, Zongming Jiang, Shuqing Liu, Xupeng Liu, Ng Shyh-Chang, Yuefan Wang, Taoyan Liu, Liping Zhang, Lu Guang, Yun Li, Luyao Guo, Wenwu Ma, Ziyue Yao, Na Ai, Ruiqi Rachel Wang, Tan J, Hefan Miao, Kun Liang

The well-conserved correlation between juvenility and tissue regeneration was first discussed by Charles Darwin. Ectopic Lin28 is known to play an important role in somatic reprogramming and tissue regeneration, but endogenous Lin28’s role in tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f6b0af4ac093c76f76f44103caa20e3
https://doi.org/10.1101/2021.10.14.462144

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Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy.

Autor: Min-Wen JC; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; Stem Cell & Regenerative Biology, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Yan-Jiang BC; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; Stem Cell & Regenerative Biology, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Mishra S; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Dai X; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Magae J; Magae Bioscience Institute, Tsukuba, Japan., Shyh-Chang N; Stem Cell & Regenerative Biology, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. Electronic address: ngsc1@gis.a-star.edu.sg., Kumar AP; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; National University Cancer Institute, National University Health System, Singapore, Singapore; University of North Texas, Denton, TX, United States. Electronic address: phcapk@nus.edu.sg., Sethi G; Magae Bioscience Institute, Tsukuba, Japan; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia. Electronic address: phcgs@nus.edu.sg.

Publikováno v: Advances in protein chemistry and structural biology [Adv Protein Chem Struct Biol] 2017; Vol. 108, pp. 199-225. Date of Electronic Publication: 2017 Feb 15.