Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Mimoun, Azzouz"'
Autor:
Claudia S. Bauer, Christopher P. Webster, Allan C. Shaw, Jannigje R. Kok, Lydia M. Castelli, Ya-Hui Lin, Emma F. Smith, Francisco Illanes-Álvarez, Adrian Higginbottom, Pamela J. Shaw, Mimoun Azzouz, Laura Ferraiuolo, Guillaume M. Hautbergue, Andrew J. Grierson, Kurt J. De Vos
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Disruption to protein homeostasis caused by lysosomal dysfunction and associated impairment of autophagy is a prominent pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). The most common genetic cause of ALS/FTD is a G4
Externí odkaz:
https://doaj.org/article/a7f7ea91bf69440699e3334d2a8e3cbe
Autor:
Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing
Externí odkaz:
https://doaj.org/article/d1a033da7da847f699478c811b28f10b
Autor:
Anett Hudák, Matthew Roach, Dávid Pusztai, Aladár Pettkó-Szandtner, Annamária Letoha, László Szilák, Mimoun Azzouz, Tamás Letoha
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3141 (2023)
Due to their low pathogenicity, immunogenicity, and long-term gene expression, adeno-associated virus (AAV) vectors emerged as safe and efficient gene delivery tools, over-coming setbacks experienced with other viral gene delivery systems in early ge
Externí odkaz:
https://doaj.org/article/c818125232fa4362a1426589980c8917
Autor:
Lucy Crooks, Johnathan Cooper-Knock, Paul R. Heath, Ahmed Bouhouche, Mostafa Elfahime, Mimoun Azzouz, Youssef Bakri, Mohammed Adnaoui, Azeddine Ibrahimi, Saaïd Amzazi, Rachid Tazi-Ahnini
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Large-scale human sequencing projects have described around a hundred-million single nucleotide variants (SNVs). These studies have predominately involved individuals with European ancestry despite the fact that genetic diversity
Externí odkaz:
https://doaj.org/article/c3092935033c4ed3986098cac62601f5
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons. As with the majority of neurodegenerative diseases, the pathological hallmarks of ALS inv
Externí odkaz:
https://doaj.org/article/b8ec5ea2abf04bb9bbcbbccd0d4ed7de
Autor:
Yilin Han, Marianne King, Evgenii Tikhomirov, Povilas Barasa, Cleide Dos Santos Souza, Jonas Lindh, Daiva Baltriukiene, Laura Ferraiuolo, Mimoun Azzouz, Maurizio R. Gullo, Elena N. Kozlova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5788 (2022)
Three-dimensional (3D) cultures, so-called organoids, have emerged as an attractive tool for disease modeling and therapeutic innovations. Here, we aim to determine if boundary cap neural crest stem cells (BC) can survive and differentiate in gelatin
Externí odkaz:
https://doaj.org/article/b39893de087f4fbb956b3e4c45593e33
Publikováno v:
BioMed Research International. 2023:1-12
Autoimmune polyglandular syndrome type 1 (APS-1) is an inherited autosomal disorder. The most common clinical features of the disease include adrenocortical failure, hypoparathyroidism (HP), and chronic mucocutaneous candidiasis (CMC). APS-1 is cause
Publikováno v:
Nature Reviews neurology
Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. ALS causes death, usually within 2-5 years of diagnosis. Riluzole, the only drug curr
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 9, Pp n/a-n/a (2020)
Abstract Objectives Autoimmune polyglandular syndrome type‐1 (APS‐1) is a monogenic recessive disorder characterised by multiple endocrine abnormalities, chronic mucocutaneous candidiasis and high titres of serum autoantibodies. To date, no curat
Externí odkaz:
https://doaj.org/article/5cad1fbd829a4b7c91766a4052a61c57
Autor:
Tommaso Iannitti, Joseph M. Scarrott, Shibi Likhite, Ian R.P. Coldicott, Katherine E. Lewis, Paul R. Heath, Adrian Higginbottom, Monika A. Myszczynska, Marta Milo, Guillaume M. Hautbergue, Kathrin Meyer, Brian K. Kaspar, Laura Ferraiuolo, Pamela J. Shaw, Mimoun Azzouz
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 75-88 (2018)
Of familial amyotrophic lateral sclerosis (fALS) cases, 20% are caused by mutations in the gene encoding human cytosolic Cu/Zn superoxide dismutase (hSOD1). Efficient translation of the therapeutic potential of RNAi for the treatment of SOD1-ALS pati
Externí odkaz:
https://doaj.org/article/b30506436b9849bf842271b7ed602925