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Akademický článek

Tilianin improves cognition in a vascular dementia rodent model by targeting miR-193b-3p/CaM- and miR-152-3p/CaMKIIα-mediated inflammatory and apoptotic pathways

Autor: Ting Sun, Linjie Tan, Mimin Liu, Li Zeng, Kaiyue Zhao, Zhongdi Cai, Shengnan Sun, Zhuorong Li, Rui Liu

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionAlthough vascular dementia (VaD) is the second most prevalent form of dementia, there is currently a lack of effective treatments. Tilianin, isolated from the traditional drug Dracocephalum moldavica L., may protect against ischemic injur

Externí odkaz: https://doaj.org/article/1a41e1326f5c49e296f00f95d394929e

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Akademický článek

Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease

Autor: Li Zeng, Hailun Jiang, Ghulam Md Ashraf, Jianghong Liu, Linlin Wang, Kaiyue Zhao, Mimin Liu, Zhuorong Li, Rui Liu

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 256-275 (2022)

Existing studies have revealed that microRNAs (miRNAs) have a role in cognitive deficits in Alzheimer’s disease (AD). However, the function and pathophysiological mechanism of deregulated miRNAs underlying AD pathology remain to be investigated. Th

Externí odkaz: https://doaj.org/article/c26f3b05c70c4f63b501ed82ef0e3afe

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Akademický článek

Role of traditional Chinese medicine in ameliorating mitochondrial dysfunction via non-coding RNA signaling: Implication in the treatment of neurodegenerative diseases

Autor: Zhongdi Cai, Mimin Liu, Li Zeng, Kaiyue Zhao, Chenyu Wang, Ting Sun, Zhuorong Li, Rui Liu

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Neurodegenerative diseases (NDs) are common chronic disorders associated with progressive nervous system damage, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, among others. Mitochondria are abundant in various ne

Externí odkaz: https://doaj.org/article/9fac1b182a2141b68f860da62606d03b

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Akademický článek

RNA sequencing-based identification of the regulatory mechanism of microRNAs, transcription factors, and corresponding target genes involved in vascular dementia

Autor: Kaiyue Zhao, Li Zeng, Zhongdi Cai, Mimin Liu, Ting Sun, Zhuorong Li, Rui Liu

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Vascular dementia (VaD) is the second most common form of dementia with uncertain mechanisms and no effective treatments. microRNAs (miRNAs) and transcription factors (TFs) are considered regulatory factors of genes involved in many diseases. Therefo

Externí odkaz: https://doaj.org/article/6e3595917ee44cce815579fe281c51e1

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Akademický článek

Identification of miRNA and Their Regulatory Effects Induced by Total Flavonoids From Dracocephalum moldavica in the Treatment of Vascular Dementia

Autor: Mimin Liu, Guangzhi Shan, Hailun Jiang, Li Zeng, Kaiyue Zhao, Yiran Li, Ghulam Md Ashraf, Zhuorong Li, Rui Liu

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Vascular dementia (VaD) is a general term used to describe difficulties in memory, reasoning, judgment, and planning caused by a reduced blood flow to the brain and consequent brain damage, in which microRNAs (miRNAs) are involved. Dracocephalum mold

Externí odkaz: https://doaj.org/article/4c03b56579d6401bb45e0504c1a448eb

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Exploration of the Molecular Mechanisms of Hyssopus cuspidatus Boriss Treatment of Asthma in an mRNA-miRNA Network via Bioinformatics Analysis

Autor: Zhongdi Cai, Mimin Liu, Fengjuan Yuan, Li Zeng, Kaiyue Zhao, Ting Sun, Zhuorong Li, Rui Liu

Publikováno v: BioMed Research International. 2022:1-21

Hyssopus cuspidatus Boriss (H. cuspidatus) is a traditional Chinese medicine commonly used in the treatment of asthma. In the present study, we applied bioinformatics techniques for mRNA-miRNA profiling to elucidate the potential mechanisms of H. cus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3ccabff66068a5c1b222f59ef82371
https://doi.org/10.1155/2022/7111901

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The Relationship between the Aberrant Long Non-Coding RNA-Mediated Competitive Endogenous RNA Network and Alzheimer's Disease Pathogenesis

Autor: Zhongdi Cai, Kaiyue Zhao, Li Zeng, Mimin Liu, Ting Sun, Zhuorong Li, Rui Liu

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8497

Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by cognitive dysfunction. The role of long non-coding RNAs (lncRNAs) with the action of competitive endogenous RNA (ceRNA) in AD remains unclear. The present study aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7397119cb984553be1fb0cbd7889fc1f
https://pubmed.ncbi.nlm.nih.gov/35955632

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Akademický článek

Tilianin improves cognition in a vascular dementia rodent model by targeting miR-193b-3p/CaM- and miR-152-3p/CaMKIIamediated inflammatory and apoptotic pathways.

Autor: Ting Sun, Linjie Tan, Mimin Liu, Li Zeng, Kaiyue Zhao, Zhongdi Cai, Shengnan Sun, Zhuorong Li, Rui Liu

Publikováno v: Frontiers in Immunology; 2023, p1-20, 20p

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miR-30a-5p induces Aβ production via inhibiting the nonamyloidogenic pathway in Alzheimer's disease

Autor: Ting Sun, Kaiyue Zhao, Mimin Liu, Zhongdi Cai, Li Zeng, Junxia Zhang, Zhuorong Li, Rui Liu

Publikováno v: Pharmacological research. 178

Alzheimer's disease (AD) pathogenesis is known to involve a dysregulation of microRNA expression, and these intricate transcriptional cascades between multiple pathological manifestations affect brain homeostasis. Previous studies have revealed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2be28c20387e6c8cb87fcbaeb1ad2cc
https://pubmed.ncbi.nlm.nih.gov/35257899

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