Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Milton T Stubbs"'
Autor:
Farzad Hamdi, Christian Tüting, Dmitry A Semchonok, Koen M Visscher, Fotis L Kyrilis, Annette Meister, Ioannis Skalidis, Lisa Schmidt, Christoph Parthier, Milton T Stubbs, Panagiotis L Kastritis
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232540 (2020)
Here we present the structure of mouse H-chain apoferritin at 2.7 Å (FSC = 0.143) solved by single particle cryogenic electron microscopy (cryo-EM) using a 200 kV device, the Thermo Fisher Glacios®. This is a compact, two-lens illumination system w
Externí odkaz:
https://doaj.org/article/ce381ff2427445a7947ff822af7eb63e
Autor:
Lisa Schmidt, Christian Tüting, Fotis L. Kyrilis, Farzad Hamdi, Dmitry A. Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Milton T. Stubbs, Andrea Sinz, Panagiotis L. Kastritis
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The high abundance of most viruses in infected host cells benefits their structural characterization. However, endogenous viruses are present in low copy numbers and are therefore challenging to investigate. Here, we retrieve cell extracts e
Externí odkaz:
https://doaj.org/article/b2213ea566234e8b8a773838896395a9
Autor:
Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge, Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Iwata, Norimichi Nomura, Milton T. Stubbs, Mikio Tanabe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The multidrug resistance transporter mediated efflux of antibiotics from the bacterial cytoplasm represents a major challenge to medicine. Here authors solve the X-ray crystallographic structure of the drug/H+ antiporter MdfA from Escherichia coli an
Externí odkaz:
https://doaj.org/article/9c31b685bee4442382a7b84e7402aa22
Autor:
Lisa Schmidt, Christian Tüting, Fotis L. Kyrilis, Farzad Hamdi, Dmitry A. Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Pranav N. M. Shah, Milton T. Stubbs, Andrea Sinz, David I. Stuart, Panagiotis L. Kastritis
The high abundance of most viruses in infected host cells benefits their structural characterization; endogenous viruses are present in low copy numbers, however, and are therefore challenging to investigate. Here, we retrieve cell extracts enriched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743ec44aa3e5350e31c1f7b4d54fc2c3
https://doi.org/10.1101/2022.07.15.498668
https://doi.org/10.1101/2022.07.15.498668
Autor:
Archna Archna, Constanze Breithaupt, Duc-Anh Nguyen, Hauke Lilie, Jorg Ziegler, Milton T. Stubbs
MqnA, the only chorismate dehydratase known so far, catalyzes the initial step in the biosynthesis of menaquinone via the futalosine pathway. Here we present crystal structures of Streptomyces coelicolor MqnA and its active site variants in complex w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201970f4ddae44a7c6887a77e30fb793
https://doi.org/10.26434/chemrxiv-2022-dhhzn
https://doi.org/10.26434/chemrxiv-2022-dhhzn
Autor:
Archna Prasad, Constanze Breithaupt, Duc-Anh Nguyen, Hauke Lilie, Jörg Ziegler, Milton T. Stubbs
Publikováno v:
Journal of Biological Chemistry. 298:102601
MqnA, the only chorismate dehydratase known so far, catalyzes the initial step in the biosynthesis of menaquinone via the futalosine pathway. Details of the MqnA reaction mechanism remain unclear. Here, we present crystal structures of Streptomyces c
Autor:
Miriam Linnert, Stephan Schilling, Hans-Ulrich Demuth, Mirko Buchholz, Jens-Ulrich Rahfeld, John A. Houston, Christoph Parthier, Florian Veillard, Nadine Taudte, Anke Piechotta, Milton T. Stubbs, Petr Kolenko, Jan Potempa, Daniel Ramsbeck, Sigrun Eick
Publikováno v:
The Journal of Biological Chemistry
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens-Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans-Ulrich; Stubbs, Milton T (2021). Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis. The journal of biological chemistry, 296, p. 100263. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100263
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens-Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans-Ulrich; Stubbs, Milton T (2021). Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis. The journal of biological chemistry, 296, p. 100263. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100263
The development of a targeted therapy would significantly improve the treatment of periodontitis and its associated diseases including Alzheimer's disease, rheumatoid arthritis, and cardiovascular diseases. Glutaminyl cyclases (QCs) from the oral pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b44849e5bf631c10995725a3bbf87c2
https://publica.fraunhofer.de/handle/publica/267517
https://publica.fraunhofer.de/handle/publica/267517
Publikováno v:
Die Pharmaindustrie ISBN: 9783662610343
Die Wurzeln der Arzneimittelforschung reichen zuruck bis in die Anfange der Menschheitsgeschichte. Von jeher war es der Traum, auf gezieltem Weg zu Therapeutika zu gelangen. Schon fur die ersten Hochkulturen ist der Einsatz pflanzlicher, mineralische
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9f026a8a3c7f8e7eaa7a49453dbaaa
https://doi.org/10.1007/978-3-662-61035-0_2
https://doi.org/10.1007/978-3-662-61035-0_2
Autor:
Danilo Meyer, Camila A. Cotrim, Nadine Strehmel, Tula B. Bisol, Wolfgang Brandt, Ludger A. Wessjohann, Milton T. Stubbs, Annett Weidner
Publikováno v:
ChemistrySelect. 2:9319-9325
Menaquinone (MK) is an electron carrier molecule essential for respiration in most Gram positive bacteria. A crucial step in MK biosynthesis involves the prenylation of an aromatic molecule, catalyzed by integral membrane prenyltransferases of the Ub
Autor:
Milton T. Stubbs, Stephan Schilling, Hans-Ulrich Demuth, Jens-Ulrich Rahfeld, Christoph Parthier, Martin Kleinschmidt, Anke Piechotta, Inge Lues, Kathrin Gnoth, Thierry Pillot
Publikováno v:
Journal of Biological Chemistry. 292:12713-12724
Alzheimer disease is associated with deposition of the amyloidogenic peptide Aβ in the brain. Passive immunization using Aβ-specific antibodies has been demonstrated to reduce amyloid deposition both in vitro and in vivo. Because N-terminally trunc