Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Milton L. Truong"'
Autor:
Roman V. Shchepin, Eduard Y. Chekmenev, Milton L. Truong, Aaron M. Coffey, Wellington Pham, Ken Wilkens
Publikováno v:
Analytical Chemistry
An open-source hyperpolarizer producing (13)C hyperpolarized contrast agents using parahydrogen induced polarization (PHIP) for biomedical and other applications is presented. This PHIP hyperpolarizer utilizes an Arduino microcontroller in conjunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26889174a951390c2078ae5314d213e4
https://doi.org/10.1021/acs.analchem.6b02130
https://doi.org/10.1021/acs.analchem.6b02130
Aqueous NMR Signal Enhancement by Reversible Exchange in a Single Step Using Water-Soluble Catalysts
Autor:
Kevin W. Waddell, Fan Shi, Eduard Y. Chekmenev, Roman V. Shchepin, Kirsten A. Groome, Greg Zimay, Milton L. Truong, Quinn A. Best, Aaron M. Coffey, Boyd M. Goodson, Ping He
Publikováno v:
The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Two synthetic strategies are investigated for the preparation of water-soluble iridium-based catalysts for NMR signal amplification by reversible exchange (SABRE). In one approach, PEGylation of a variant N-heterocyclic carbene provided a novel catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c0e0eb40ef8e5523f449ba622b1c36
https://doi.org/10.1021/acs.jpcc.6b04484
https://doi.org/10.1021/acs.jpcc.6b04484
Autor:
Eduard Y. Chekmenev, Thomas Theis, Milton L. Truong, Warren S. Warren, Fan Shi, Roman V. Shchepin, Kevin W. Waddell, Aaron M. Coffey, Boyd M. Goodson
Publikováno v:
The Journal of Physical Chemistry Letters
We report NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization of the rare isotopes in "neat" liquids, each composed only of an otherwise pure target compound with isotopic natural abundance (n.a.) and millimolar concentrations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374ae552b698202d164296dadf78d05b
https://doi.org/10.1021/acs.jpclett.5b00782
https://doi.org/10.1021/acs.jpclett.5b00782
Autor:
Aaron M. Coffey, Fan Shi, Eduard Y. Chekmenev, Warren S. Warren, Kevin W. Waddell, Milton L. Truong, Thomas Theis, Roman V. Shchepin, Boyd M. Goodson
Publikováno v:
The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
NMR signal amplification by reversible exchange (SABRE) is a NMR hyperpolarization technique that enables nuclear spin polarization enhancement of molecules via concurrent chemical exchange of a target substrate and parahydrogen (the source of spin o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182b1bbbf2aff634bbf02e2457b05709
https://doi.org/10.1021/acs.jpcc.5b01799
https://doi.org/10.1021/acs.jpcc.5b01799
Autor:
Eduard Y. Chekmenev, Fan Shi, Thomas Theis, Kevin W. Waddell, Milton L. Truong, Warren S. Warren, Aaron M. Coffey, Roman V. Shchepin, Boyd M. Goodson
Publikováno v:
Journal of the American Chemical Society
Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda151a37d221d413032f647dac2a323
http://europepmc.org/articles/PMC4333583
http://europepmc.org/articles/PMC4333583
Autor:
Matthew A. Feldman, Roman V. Shchepin, Aaron M. Coffey, Eduard Y. Chekmenev, Danila A. Barskiy, Wellington Pham, Milton L. Truong
High-resolution 13C NMR spectroscopy of hyperpolarized succinate-1-13C is reported in vitro and in vivo using a clinical-scale, biplanar (80 cm-gap) 48.7 mT permanent magnet with a high homogeneity magnetic field. Non-localized 13C NMR spectra were r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687f47610634ae62dfd48894a52c9700
https://europepmc.org/articles/PMC5544012/
https://europepmc.org/articles/PMC5544012/
Autor:
Kevin W. Waddell, Eduard Y. Chekmenev, Roman V. Shchepin, Kirill V. Kovtunov, Milton L. Truong, Danila A. Barskiy, Boyd M. Goodson, Kirsten A. Groome, Aaron M. Coffey, Ping He, Fan Shi, Quinn A. Best, Igor V. Koptyug
Publikováno v:
ChemPhysChem. 15:4100-4107
By using 5.75 and 47.5 mT nuclear magnetic resonance (NMR) spectroscopy, up to 10(5)-fold sensitivity enhancement through signal amplification by reversible exchange (SABRE) was enabled, and subsecond temporal resolution was used to monitor an exchan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d8d8483c1f578e061a6aa4efd04057
https://doi.org/10.1002/cphc.201402607
https://doi.org/10.1002/cphc.201402607
Publikováno v:
Journal of Magnetic Resonance. 248:23-26
Nuclear spin hyperpolarization overcomes the sensitivity limitations of traditional NMR and MRI, but the most general method demonstrated to date (dynamic nuclear polarization) has significant limitations in scalability, cost, and complex apparatus d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f78aa0c67380acfacc447fae506a11
https://doi.org/10.1016/j.jmr.2014.09.005
https://doi.org/10.1016/j.jmr.2014.09.005
Publikováno v:
Contrast Media & Molecular Imaging. 9:333-341
Indirect proton detection of 13C hyperpolarized contrast agents potentially enables greater sensitivity. Presented here is a study of sub-second projection imaging of hyperpolarized 13C contrast agent addressing the obstacle posed by water suppressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55a9e1609d76a037df60049728d3171a
https://doi.org/10.1002/cmmi.1579
https://doi.org/10.1002/cmmi.1579
Autor:
Kevin W. Waddell, Milton L. Truong, Kirill V. Kovtunov, Eduard Y. Chekmenev, Danila A. Barskiy, Aaron M. Coffey, Igor V. Koptyug
Parahydrogen induced polarization was employed to prepare a relatively long-lived correlated nuclear spin state between methylene and methyl protons in propane gas. Conventionally, such states are converted into a strong NMR signal enhancement by tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364523bd715cfe8334b81911ef9f4bc2
https://europepmc.org/articles/PMC4287377/
https://europepmc.org/articles/PMC4287377/