Výsledky vyhledávání - "Milton L. Pressler"

Akademický článek

The Weight of Evidence From Electrophysiology, Observational, and Cardiovascular End Point Studies Demonstrates the Safety of Azithromycin

Autor: Jack Cook, Milton L. Pressler, Bharat Damle, Demissie Alemayehu, Charles A. Knirsch

Publikováno v: Clinical and Translational Science, Vol 14, Iss 1, Pp 106-112 (2021)

Increased use of azithromycin (AZ) in treating infections associated with coronavirus disease 2019 (COVID‐19) and reports of increased incidence of prolonged corrected QT (QTc) interval associated with AZ used with hydroxychloroquine prompted us to

Externí odkaz: https://doaj.org/article/a614d481d60242c8bcf4c4c26c354a11

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The Weight of Evidence From Electrophysiology, Observational, and Cardiovascular End Point Studies Demonstrates the Safety of Azithromycin

Autor: Demissie Alemayehu, Bharat Damle, Milton L. Pressler, Charles Knirsch, Jack Cook

Publikováno v: Clinical and Translational Science, Vol 14, Iss 1, Pp 106-112 (2021)
Clinical and Translational Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce38543bbdcfe0d6fedd255bd134118
https://doi.org/10.1111/cts.12867

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Strengthening the interpretability of clinical trial results by assessing the effect of informative censoring on the primary estimand in PRECISION

Autor: Wayne Wisemandle, Steven E. Nissen, Bruce Beckerman, Katherine E. Wolski, Weihang Bao, Rana Fayyad, Michael Gaffney, Milton L. Pressler

Publikováno v: Clinical Trials. 17:535-544

Background: The ICH E9(R1) addendum states that the strategy to account for intercurrent events should be included when defining an estimand, the treatment effect to be estimated based on the study objective. The estimator used to assess the treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3bb13f6c0e58b2d2cc8621954b072d
https://doi.org/10.1177/1740774520934747

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Blood Pressure Lowering Effects of a New Long-Acting Inhibitor of Phosphodiesterase 5 in Patients With Mild to Moderate Hypertension

Autor: Milton L. Pressler, Dawei Xuan, James Gilbert, Robert Wolk, William B. Smith, Joel M. Neutel, James P. Mancuso, John Rubino

Publikováno v: Hypertension. 53:1091-1097

Inhibition of phosphodiesterase 5 is an attractive candidate mechanism for blood pressure (BP) lowering. In this study, a novel long-acting phosphodiesterase 5 inhibitor, PF-00489791, was evaluated in 133 patients with mild to moderate hypertension,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621fcc30e110adac11dab05666692a0e
https://doi.org/10.1161/hypertensionaha.109.132225

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Effects of the Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor Avasimibe on Human Atherosclerotic Lesions

Autor: Fernando Alfonso, Jean-Claude Tardif, Milton L. Pressler, François Reeves, Jean Grégoire, Jacques Lespérance, Olivier F. Bertrand, Lawrence M. Title, Todd J. Anderson, Josep Rodés-Cabau, Alita Hassan, Richard McLain, Therese Heinonen, John Blue, Erick Schampaert, Philippe L. L’Allier, Reda Ibrahim

Publikováno v: Circulation. 110:3372-3377

Background— Inhibition of the acyl coenzyme A:cholesterol acyltransferase (ACAT) enzyme may prevent excess accumulation of cholesteryl esters in macrophages. The ACAT inhibitor avasimibe was shown to reduce experimental atherosclerosis. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcea4a5239ea1858fe2da96eadcd2e50
https://doi.org/10.1161/01.cir.0000147777.12010.ef

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Effects of angiotensin-converting enzyme inhibition on transient ischemia

Autor: Patrick Ma, Anique Ducharme, Karen Annis, S. Ben Freedman, Harry E. Haber, Jacques Lenis, Richard F. Davies, Udho Thadani, Milton L. Pressler, Bernard R. Chaitman, Jean-Lucien Rouleau, Carl J. Pepine, Bertram Pitt

Publikováno v: Journal of the American College of Cardiology. 42(12):2049-2059

OBJECTIVES We sought to determine whether angiotensin-converting enzyme inhibition (ACE-I) (i.e., quinapril) prevents transient ischemia (exertional and spontaneous) in patients with coronary artery disease (CAD). BACKGROUND It is known that ACE-I re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4118e187f4fd1e2ef8fd58902960ae54

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Regional angiogenesis with vascular endothelial growth factor (VEGF) in peripheral arterial disease: Design of the RAVE trial

Autor: Jeffrey W. Olin, Emile R. Mohler, Milton L. Pressler, Corey K. Goldman, Alan T. Hirsch, Jorge F Saucedo, Robert J. Lederman, John Blebea, Farrell O. Mendelsohn, Jeffrey D Trachtenberg, Henrik S. Rasmussen, Brian H. Annex, Sanjay Rajagopalan

Publikováno v: American Heart Journal. 145:1114-1118

Background Patients with intermittent claudication caused by infrainguinal atherosclerosis have limited pharmacologic options “Therapeutic angiogenesis” is a novel treatment approach that seeks to improve perfusion of ischemic limbs by the induct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d6076e773e57f92873410a22f4f4b2
https://doi.org/10.1016/s0002-8703(03)00102-9

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Diuretic resistance predicts mortality in patients with advanced heart failure

Autor: John H. Wertheimer, Anne B. Cropp, Milton L. Pressler, Alan B. Miller, Milton Packer, Robert N. Belkin, Gerald W. Neuberg, Regina G. Nye, Peter E. Carson, David J. Frid, Christopher M. O'Connor

Publikováno v: American Heart Journal. 144:31-38

Background In patients with chronic heart failure (CHF), diuretic requirements increase as the disease progresses. Because diuretic resistance can be overcome with escalating doses, the evaluation of CHF severity and prognosis may be incomplete witho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf146ed795385c28090273e8fc16546e
https://doi.org/10.1067/mhj.2002.123144

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Acute Hemodynamic Effects of Conivaptan, a Dual V 1A and V 2 Vasopressin Receptor Antagonist, in Patients With Advanced Heart Failure

Autor: Francoise Chanoine, William B. Smith, Jalal K. Ghali, Maha Ghazzi, Grady H. Hendrix, Milton L. Pressler, James E. Udelson, Christopher A. Painchaud, Ignatius Thomas, Marvin A. Konstam, Paulina Selaru

Publikováno v: Circulation. 104:2417-2423

Background Arginine vasopressin may contribute to abnormalities in hemodynamics and fluid balance in heart failure through its actions on V 1A (vascular and myocardial effects) and V 2 receptors (renal effects). Inhibiting the action of vasopressin m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee01e07a62869953d8c62d869c45622
https://doi.org/10.1161/hc4501.099313

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