Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Milton L. Hammond"'
Autor:
Katherine Young, Ronald E. Painter, Susan L. Raghoobar, Nichelle N. Hairston, Fred Racine, Douglas Wisniewski, Carl J. Balibar, Artjohn Villafania, Rumin Zhang, Daniel F. Sahm, Timothy Blizzard, Nicholas Murgolo, Milton L. Hammond, Mary R. Motyl
Publikováno v:
BMC Microbiology, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background The prevalence of antibiotic resistance is increasing, and multidrug-resistant Pseudomonas aeruginosa has been identified as a serious threat to human health. The production of β-lactamase is a key mechanism contributing to imipe
Externí odkaz:
https://doaj.org/article/74bfca45a65f4093988417ba76437c53
Autor:
Nichelle Hairston, Katherine Young, Artjohn Villafania, Milton L. Hammond, Nicholas Murgolo, Ronald E. Painter, Douglas Wisniewski, Mary Motyl, Daniel F. Sahm, Rumin Zhang, Carl J. Balibar, Fred Racine, Timothy A. Blizzard, Susan L. Raghoobar
Publikováno v:
BMC Microbiology
BMC Microbiology, Vol 19, Iss 1, Pp 1-14 (2019)
BMC Microbiology, Vol 19, Iss 1, Pp 1-14 (2019)
Background The prevalence of antibiotic resistance is increasing, and multidrug-resistant Pseudomonas aeruginosa has been identified as a serious threat to human health. The production of β-lactamase is a key mechanism contributing to imipenem resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa66d7281d6be8c3899743e477650e1e
https://doi.org/10.1186/s12866-019-1522-7
https://doi.org/10.1186/s12866-019-1522-7
Autor:
Timothy A. Blizzard, Nichelle Hairston, Jason E. Imbriglio, Young-Whan Park, Douglas Wisniewski, Paula M.D. Fitzgerald, Sookhee Ha, Nandini Sharma, Katherine Young, Jane Y. Wu, Giovanna Scapin, Aimie Ogawa, Susan L. Raghoobar, Jeff Hermes, Seongkon Kim, Ronald E. Painter, Rena Bodner, Jun Lu, Candido Gude, Helen Chen, Milton L. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:780-785
β-Lactamase inhibitors with a bicyclic urea core and a variety of heterocyclic side chains were prepared and evaluated as potential partners for combination with imipenem to overcome class A and C β-lactamase mediated antibiotic resistance. The pip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef95f2cd4732f80cdeca6fafc1d4dce
https://doi.org/10.1016/j.bmcl.2013.12.101
https://doi.org/10.1016/j.bmcl.2013.12.101
Autor:
Jerry Xu, Milton L. Hammond, Brett Lauring, James R. Tata, Philip J. Skinner, Jens Knudsen, Daniel T. Connolly, Eseng Lai, Graeme Semple, Wen-Lin Luo, M. Gerard Waters, P. Douglas Boatman, John A. Wagner, Martin C. Cherrier, Jae-Kyu Jung, Steven L. Colletti, Andrew K.P. Taggart, Ester Carballo-Jane, Ruoping Chen, Benjamin R. Johnson, Thomas O. Schrader, Josee Cote, Carleton R. Sage, Luzelena Caro, Jeremy G. Richman, Michelle Kasem, Peter J. Webb
Publikováno v:
Journal of Medicinal Chemistry. 55:3644-3666
G-protein coupled receptor (GPCR) GPR109a is a molecular target for nicotinic acid and is expressed in adipocytes, spleen, and immune cells. Nicotinic acid has long been used for the treatment of dyslipidemia due to its capacity to positively affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0081f668bd4a6593577f7a79c1cb795
https://doi.org/10.1021/jm2010964
https://doi.org/10.1021/jm2010964
Autor:
Xinchun Tong, Melanie Latham, Ying Chen, Denise P. Milot, Milton L. Hammond, Amjad Ali, Eugene Tan, Sheryl A. Hyland, Carl P. Sparrow, Qiu Guo, Joann B. Napolitano, Laurence B. Peterson, Samuel D. Wright, Suoyu S. Xu, Qiaolin Deng, Yi-Heng Chen, Gayle E. Taylor, Zhijian Lu, Peter J. Sinclair, Suzanne S. Eveland, Matt S. Anderson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:199-203
SAR studies of the substitution effect on the central phenyl ring of the biphenyl scaffold were carried out using anacetrapib (9a) as the benchmark. The results revealed that the new analogs with substitutions to replace trifluoromethyl (9a) had a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d23a0727a318e5869d943562cf0bf0
https://doi.org/10.1016/j.bmcl.2011.11.039
https://doi.org/10.1016/j.bmcl.2011.11.039
Autor:
Milton L. Hammond, Anne-Marie Cumiskey, Sheryl A. Hyland, Ray Rosa, Christopher F. Thompson, Amjad Ali, Ying Chen, Suoyu S. Xu, James V. Pivnichny, Xinchun Tong, Qiu Guo, Hong Li, Carl P. Sparrow, Peter J. Sinclair, Joann B. Napolitano, Melanie Latham, Zhijian Lu, Samuel D. Wright, Laurence B. Peterson, Matt S. Anderson, Suzanne S. Eveland, Cameron J. Smith, Gayle E. Taylor, Denise P. Milot
Publikováno v:
Journal of Medicinal Chemistry. 54:4880-4895
The development of the structure-activity studies leading to the discovery of anacetrapib is described. These studies focused on varying the substitution of the oxazolidinone ring of the 5-aryloxazolidinone system. Specifically, it was found that sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9687b925796a3dc579010acb69a718d
https://doi.org/10.1021/jm200484c
https://doi.org/10.1021/jm200484c
Autor:
Carl P. Sparrow, Milton L. Hammond, Denise P. Milot, Peter J. Sinclair, Suzanne S. Eveland, Ramzi F. Sweis, Ying Chen, Samuel D. Wright, Florida Kallashi, Julianne A. Hunt, Qiu Guo, Melanie Latham, Sheryl A. Hyland, Anne-Marie Cumiskey, Ray Rosa, Matt S. Anderson, Larry Peterson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1890-1895
The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark molecule. Reversing the connectivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6a4e5b4fb86bec5c2667ebcf40fd52
https://doi.org/10.1016/j.bmcl.2010.11.090
https://doi.org/10.1016/j.bmcl.2010.11.090
Autor:
Dooseop Kim, Qiu Guo, Ying Chen, Milton L. Hammond, Xinchun Tong, Carl P. Sparrow, Amjad Ali, Denise P. Milot, Sheryl A. Hyland, Peter J. Sinclair, Samuel D. Wright, James V. Pivnichny, Julianne A. Hunt, Suoyu S. Xu, Cameron J. Smith, Florida Kallashi, Suzanne S. Eveland, You Jung Park, Matt S. Anderson, Melanie Latham, Ray Rosa, Jennifer E. Kowalchick, Anne-Marie Cumiskey, Laurence B. Peterson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:558-561
We describe structure-activity studies leading to the discovery of 2-arylbenzoxazole 3, the first in a series to raise serum high-density lipoprotein cholesterol levels in transgenic mice. Replacement of the 4-piperidinyloxy moiety with piperazinyl p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e589804421cb20d83a5fcc59bc27fcc1
https://doi.org/10.1016/j.bmcl.2010.10.062
https://doi.org/10.1016/j.bmcl.2010.10.062
Autor:
Suzanne S. Eveland, Laurence B. Peterson, Carl P. Sparrow, Zhijian Lu, Denise P. Milot, Amjad Ali, Joann B. Napolitano, Qiu Guo, Sheryl A. Hyland, Eugene Tan, Suoyu S. Xu, Samuel D. Wright, Ying Chen, Milton L. Hammond, Melanie Latham, Peter J. Sinclair, Ashleigh B. Theberge, Matt S. Anderson, Xinchun Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7469-7472
A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fd2ff15715d0d6f5760db6460b5c89
https://doi.org/10.1016/j.bmcl.2010.10.019
https://doi.org/10.1016/j.bmcl.2010.10.019
Autor:
Matt S. Anderson, Denise P. Milot, Xinchun Tong, Ying Chen, Suzanne S. Eveland, Florida Kallashi, James V. Pivnichny, Silvia Gonzalez, Carl P. Sparrow, Julianne A. Hunt, Samuel D. Wright, Sheryl A. Hyland, Suoyu S. Xu, Qiu Guo, Milton L. Hammond, Peter J. Sinclair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1019-1022
The development of a series of 2-arylbenzoxazole alpha-alkoxyamide and beta-alkoxyamine inhibitors of cholesteryl ester transfer protein (CETP) is described. Highly fluorinated alpha-alkoxyamides proved to be potent inhibitors of CETP in vitro, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcbd104991a5e3084a4c02c62b4b93a
https://doi.org/10.1016/j.bmcl.2009.12.046
https://doi.org/10.1016/j.bmcl.2009.12.046