Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Milton L. Brown"'
Autor:
Patricia F. Boothe, Vidya P. Kumar, Yali Kong, Kan Wang, Howard Levinson, David Mu, Milton L. Brown
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8261 (2024)
Medical procedures, such as radiation therapy, are a vital element in treating many cancers, significantly contributing to improved survival rates. However, a common long-term complication of such exposure is radiation-induced skin fibrosis (RISF), a
Externí odkaz:
https://doaj.org/article/655f8cdd015e4cdb99c6be5076ce5a2c
Autor:
Scott eGrindrod, Simeng eSuy, Shannon eFallen, Masumi eEto, Jeffery eToretsky, Milton L. Brown
Publikováno v:
Frontiers in Oncology, Vol 1 (2011)
Myosin light chain phosphatase is an enzyme important to regulation of cell cycle and motility that is shown to be upregulated in aggressive prostate cancer cells and tissue. We developed a fluorescent small molecule inhibitor of myosin light chain p
Externí odkaz:
https://doaj.org/article/e63fc209017543a38fcf251b62e8e162
Autor:
Milton L. Brown, Anatoly Dritschilo, Chaoyi Zheng, Matthew Miessau, Yonghong Yang, Sivanesan Dakshanamurthy, Sung A. Lee, Alfredo Velena, Scott Grindrod, Kan Wang, Mira Jung, Yali Kong
Inhibitors of histone deacetylases (HDAC) are an important emerging class of drugs for the treatment of cancers. HDAC inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combinations with chemotherapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5aeb222f160d9bff9fe824bd987a06
https://doi.org/10.1158/1535-7163.c.6535311.v1
https://doi.org/10.1158/1535-7163.c.6535311.v1
Autor:
Milton L. Brown, Anatoly Dritschilo, Chaoyi Zheng, Matthew Miessau, Yonghong Yang, Sivanesan Dakshanamurthy, Sung A. Lee, Alfredo Velena, Scott Grindrod, Kan Wang, Mira Jung, Yali Kong
Supplementary Methods, Figures 1-4 from Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030a3dcc615c374930dd23755e04b56b
https://doi.org/10.1158/1535-7163.22496529
https://doi.org/10.1158/1535-7163.22496529
Autor:
Said Rahim, Tsion Minas, Sung-Hyeok Hong, Sarah Justvig, Haydar Çelik, Yasemin Saygideger Kont, Jenny Han, Abraham T Kallarakal, Yali Kong, Michelle A Rudek, Milton L Brown, Bhaskar Kallakury, Jeffrey A Toretsky, Aykut Üren
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114260 (2014)
The erythroblastosis virus E26 transforming sequences (ETS) family of transcription factors consists of a highly conserved group of genes that play important roles in cellular proliferation, differentiation, migration and invasion. Chromosomal transl
Externí odkaz:
https://doaj.org/article/5616112e0d4b4bc0a5240959d2aaaed3
Autor:
Jennifer L. Wilson, Milton L. Brown, Hannah Song, Parker H. Merrill, Scott M. Capitosti, Anusuya Das, Mary Caitlin P. Sok, Mikell Paige, Edward A. Botchwey, Brandon Freshcorn, Thomas C. Turner
Publikováno v:
Regenerative engineering and translational medicine
Springer International Publishing
Regenerative engineering and translational medicine, vol 5, iss 1
Springer International Publishing
Regenerative engineering and translational medicine, vol 5, iss 1
Control of microvascular network growth is critical to treatment of ischemic tissue diseases and enhancing regenerative capacity of tissue engineering implants. Conventional therapeutic strategies for inducing angiogenesis aim to deliver one or more
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19343 (2011)
Genomic rearrangements involving the ETS family of transcription factors occur in 40-70% of prostate cancer cases. ERG and ETV1 are the most common ETS members observed in these genetic alterations. The high prevalence of these rearrangements and the
Externí odkaz:
https://doaj.org/article/845b35cc6fbc4f1383e9fad6f379ce70
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2226-2233
The treatment of triple negative breast cancer (TNBC) is a significant challenge to cancer research. The lack of hormone receptors limits the treatment options available to patients with this diagnosis, forcing them to endure prolonged radiation and
Autor:
Yongxian Ma, York Tomita, Eliseu O. De Oliveira, Robert Clarke, Yumi Ueda, Anju Preet, Li Zhang, Milton L. Brown, Eliot M. Rosen
Publikováno v:
Oncotarget
Previous studies indicate that BRCA1 protein binds to estrogen receptor-alpha (ER) and inhibits its activity. Here, we found that BRCA1 over-expression not only inhibits ER activity in anti-estrogen-resistant LCC9 cells but also partially restores th
Autor:
Amir H. Rezvani, Kenneth J. Kellar, Milton L. Brown, Yong Liu, Susan Slade, Corinne Wells, Edward D. Levin, Yingxian Xiao, Venkata Mahidhar Yenugonda
Publikováno v:
European journal of pharmacology. 845
Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. Sazetidine-A has been shown in our previous studies to significantly reduce nicotine and alc