Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates

Autor: Zhu, Xuling, Yin, Ling, Theisen, Matt, Zhuo, Jenny, Siddiqui, Summar, Levy, Becca, Presnyak, Vladimir, Frassetto, Andrea, Milton, Jaclyn, Salerno, Timothy, Benenato, Kerry E., Milano, Joe, Lynn, Andy, Sabnis, Staci, Burke, Kristine, Besin, Gilles, Lukacs, Christine M., Guey, Lin T., Finn, Patrick F., Martini, Paolo G.V.

Publikováno v: In The American Journal of Human Genetics 4 April 2019 104(4):625-637

Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA.

Autor: Cornebise, Mark, Narayanan, Elisabeth, Xia, Yan, Acosta, Edward, Ci, Lei, Koch, Hillary, Milton, Jaclyn, Sabnis, Staci, Salerno, Timothy, Benenato, Kerry E.

Publikováno v: Advanced Functional Materials; Feb2022, Vol. 32 Issue 8, p1-12, 12p

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Accelerated Blood Clearance of Lipid Nanoparticles Entails a Biphasic Humoral Response of B-1 Followed by B-2 Lymphocytes to Distinct Antigenic Moieties.

Autor: Besin G; Moderna, Inc., Cambridge, MA 02139; gilles.besin@modernatx.com., Milton J; Moderna, Inc., Cambridge, MA 02139., Sabnis S; Moderna, Inc., Cambridge, MA 02139., Howell R; Moderna, Inc., Cambridge, MA 02139., Mihai C; Moderna, Inc., Cambridge, MA 02139., Burke K; Moderna, Inc., Cambridge, MA 02139., Benenato KE; Moderna, Inc., Cambridge, MA 02139., Stanton M; Generation Bio, Cambridge, MA 02142; and., Smith P; Alnylam, Cambridge, MA 02142., Senn J; Moderna, Inc., Cambridge, MA 02139., Hoge S; Moderna, Inc., Cambridge, MA 02139.

Publikováno v: ImmunoHorizons [Immunohorizons] 2019 Jul 11; Vol. 3 (7), pp. 282-293. Date of Electronic Publication: 2019 Jul 11.