Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Milou S. van Driel"'
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101050- (2022)
Summary: Intestinal organoid cultures are a powerful tool to study epithelial cells in vitro, as they are able to proliferate and differentiate into all cell lineages observed in vivo. Co-culturing organoids with distinct genetic backgrounds provides
Externí odkaz:
https://doaj.org/article/bdcc04b68bf648edb4770ee43649041c
Autor:
Sanne M van Neerven, Wouter L Smit, Milou S van Driel, Vaishali Kakkar, Nina E de Groot, Lisanne E Nijman, Clara C Elbers, Nicolas Léveillé, Jarom Heijmans, Louis Vermeulen
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-16 (2022)
Abstract The majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC. APC mutations result in oncogenic activation of the Wnt pathway, which is associated with hyperproliferation, cytoskeletal remodeling, and a
Externí odkaz:
https://doaj.org/article/891ee3363d044458ba63925b9b465371
Publikováno v:
Trends in cancer. 8(5)
The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d027da51fb3786459055ebaf814531e
https://pubmed.ncbi.nlm.nih.gov/35153158
https://pubmed.ncbi.nlm.nih.gov/35153158
Autor:
Edward Morrissey, Leandro F. Moreno, Vaishali Kakkar, Maria C. Lecca, Douglas J. Winton, Przemek M. Krawczyk, Prashanthi Ramesh, Jan Paul Medema, Louis Vermeulen, Arthur S. Aelvoet, Daniël O. Warmerdam, Nina E. de Groot, Milou S. van Driel, Lisanne E. Nijman, Jan Koster, Nicolas Léveillé, Evelien Dekker, Sanne ten Hoorn, Felipe A. Vieira Braga, Sanne M. van Neerven, Lianne Koens, Marouska F. van Boxel, Maarten F. Bijlsma, Delano R. Sanches, Brendon P. Scicluna
Publikováno v:
Nature
Nature, 594(7863), 436-441. Nature Publishing Group
Nature, 594(7863), 436-441. Nature Publishing Group
A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the gut lining. Disruption of this balance by mutations in the tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aa823e300aa04c0d10dea937321075
Publikováno v:
Trends in cancer, 7(8), 664-665. Cell Press
A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e389323450c819bd4d6558cf0c2c49
https://doi.org/10.1016/j.trecan.2021.06.005
https://doi.org/10.1016/j.trecan.2021.06.005
Autor:
James Laycock, Mahnaz Darvish-Damavandi, Simon J.A. Buczacki, Christopher M. Ward, Mae A. Goldgraben, Milou S van Driel
Publikováno v:
The British Journal of Surgery
British Journal of Surgery
British Journal of Surgery
SARS-CoV-2 is the causative agent for the COVID-19 pandemic. COVID-19 has necessitated rapid changes in surgical practice and organisation through both the initial peak and ongoing recovery period 1. SARS-CoV-2 infects cells by interacting with the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b2e988e724b56c599f652ffb39dede
https://pubmed.ncbi.nlm.nih.gov/32776522
https://pubmed.ncbi.nlm.nih.gov/32776522