Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Milota Kaluzová"'
Publikováno v:
BioTechniques, Vol 36, Iss 2, Pp 228-234 (2004)
Externí odkaz:
https://doaj.org/article/9eb1afeeb3074435ac90bf42a663a2f9
Publikováno v:
BioTechniques, Vol 26, Iss 3, Pp 446-450 (1999)
Externí odkaz:
https://doaj.org/article/932a4ad9435241a0832fc151b593b0e3
Publikováno v:
Science. 324:654-657
Circadian Oscillations The 24-hour day-night cycle plays an important role in mammalian physiology and behavior and, as most travelers are well aware, there is an intimate link between our in-built circadian clocks and metabolic rhythms. This link is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f65b254626036fd4e157a3993f8b746
https://doi.org/10.1126/science.1170803
https://doi.org/10.1126/science.1170803
Autor:
Paolo Sassone-Corsi, Yasukazu Nakahata, Satoru Masubuchi, Benedetto Grimaldi, Milota Kaluzová
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 41:81-86
Circadian rhythms govern a wide variety of physiological and metabolic functions in almost all organisms. These are controlled by the circadian clock machinery, which is mostly based on transcriptional-translational feedback loops. Importantly, 10-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba3c5f4e8598cd673bd71a9e1038cfb
https://doi.org/10.1016/j.biocel.2008.08.035
https://doi.org/10.1016/j.biocel.2008.08.035
Publikováno v:
Biochemical and Biophysical Research Communications. 370:613-618
The hypoxia-inducible factor (HIF) activates transcription via binding to the highly variable hypoxia-responsive elements (HREs). All hypoxia-inducible constructs described to date utilize multimers of naturally occurring HREs. Here, we describe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fb6eac7123aef40f94db26a4efd165
https://doi.org/10.1016/j.bbrc.2008.03.147
https://doi.org/10.1016/j.bbrc.2008.03.147
Publikováno v:
Molecular and Cellular Biology. 24:5757-5766
We investigated the relationship between the tumor suppressor p53 and the hypoxia-inducible factor-1 (HIF-1)-dependent expression of the hypoxia marker, carbonic anhydrase IX (CAIX). MCF-7 (wt p53) and Saos-2 (p53-null) cells displayed similar induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ff3ca5ee32096d3a89babc8bf606fb
https://doi.org/10.1128/mcb.24.13.5757-5766.2004
https://doi.org/10.1128/mcb.24.13.5757-5766.2004
Autor:
Seppo Parkkila, Silvia Pastorekova, Jaromir Pastorek, Milota Kaluzová, Július Rajčáni, Stefan Kaluz, Adrian Chrastina, Jan Zavada
Publikováno v:
International Journal of Cancer. 105:873-881
Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83818e0dc6c18ccd5a592c5742cefcbc
https://doi.org/10.1002/ijc.11142
https://doi.org/10.1002/ijc.11142
Transcriptional Regulation of the MN/CA 9 Gene Coding for the Tumor-associated Carbonic Anhydrase IX
Autor:
Adriana Gibadulinova, René Opavský, R. Kettmann, Jaromir Pastorek, Silvia Pastorekova, Franck Dequiedt, Milota Kaluzová, Stefan Kaluz
Publikováno v:
Journal of Biological Chemistry. 274:32588-32595
The MN/CA 9 (MN) gene encodes a tumor-associated isoenzyme of the carbonic anhydrase family. Functional characterization of the 3.5-kilobase pair MN 5′ upstream region by deletion analysis led to the identification of the −173 to +31 fragment as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2614a29238dd26472585113c76d225c7
https://doi.org/10.1074/jbc.274.46.32588
https://doi.org/10.1074/jbc.274.46.32588
Transcriptional activation by hypoxia is mediated by the hypoxia-inducible factor (HIF) via binding to the hypoxia-responsive element (HRE). Hypoxia in solid tumors associates with poorer outcome of the disease and reliable cellular markers of tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970e83f2c6373dfcb29f8b5caab95542
https://europepmc.org/articles/PMC2670353/
https://europepmc.org/articles/PMC2670353/
Autor:
Paolo Sassone-Corsi, Yasukazu Nakahata, Milota Kaluzová, Danica Chen, Jun Hirayama, Benedetto Grimaldi, Saurabh Sahar, Leonard Guarente
SummaryCircadian rhythms govern a large array of metabolic and physiological functions. The central clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, an event essential for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125243c261d1764fbd18685f498a5e4e
https://europepmc.org/articles/PMC3526943/
https://europepmc.org/articles/PMC3526943/