Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Milos S Simic"'
Publikováno v:
eLife, Vol 11 (2022)
Opioid tolerance is well-described physiologically but its mechanistic basis remains incompletely understood. An important site of opioid action in vivo is the presynaptic terminal, where opioids inhibit transmitter release. This response characteris
Externí odkaz:
https://doaj.org/article/bf24da8ed7a64fe89ed60df6ff8a71b5
Autor:
Peter M. Douglas, Nathan A. Baird, Milos S. Simic, Sarah Uhlein, Mark A. McCormick, Suzanne C. Wolff, Brian K. Kennedy, Andrew Dillin
Publikováno v:
Cell Reports, Vol 12, Iss 7, Pp 1196-1204 (2015)
Integrating stress responses across tissues is essential for the survival of multicellular organisms. The metazoan nervous system can sense protein-misfolding stress arising in different subcellular compartments and initiate cytoprotective transcript
Externí odkaz:
https://doaj.org/article/a18f0b3be3334f53973a6697464743b0
Autor:
Kyle G. Daniels, Shangying Wang, Milos S. Simic, Hersh K. Bhargava, Sara Capponi, Yurie Tonai, Wei Yu, Simone Bianco, Wendell A. Lim
Publikováno v:
Science (New York, N.Y.), vol 378, iss 6625
Chimeric antigen receptor (CAR) costimulatory domains derived from native immune receptors steer the phenotypic output of therapeutic T cells. We constructed a library of CARs containing ~2300 synthetic costimulatory domains, built from combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5737939b2c6b5d9158eb7b7a59cc445d
https://escholarship.org/uc/item/2sw7v1q4
https://escholarship.org/uc/item/2sw7v1q4
Autor:
Choe Joseph H, Anna Celli, Juhyun Cho, Kira Downey, Wei Yu, Olga G. Troyanskaya, Aileen W. Li, Diego Carrera, Ruth Dannenfelser, Yitzhar E. Goretsky, Kole T. Roybal, Jessica D. Briones, Sachdev S. Sidhu, Wendell A. Lim, Ryan Gilbert, Lia Cardarelli, Nira A. Krasnow, Milos S. Simic, Hideho Okada, Jason M. Duecker, Payal Watchmaker
Publikováno v:
Science translational medicine, vol 13, iss 591
Sci Transl Med
Sci Transl Med
Treatment of solid cancers with chimeric antigen receptor (CAR) T cells is plagued by the lack of ideal target antigens that are both absolutely tumor specific and homogeneously expressed. We show that multi-antigen prime-and-kill recognition circuit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b526cc204fad3a7a0516aa6cc3ee6df1
https://escholarship.org/uc/item/64p7w6f3
https://escholarship.org/uc/item/64p7w6f3
Autor:
Wendell A. Lim, Milos S. Simic, Kira M. Downey, Aileen W. Li, Jessica D. Briones, Anna Celli, Nira A. Krasnow, Wei Yu, Choe Joseph H, Lia Cardarelli, Payal Watchmaker, Kole T. Roybal, Diego A. Carrera, Sachdev S. Sidhu, Ryan Gilbert, Juhyun Cho, Hideho Okada, Ruth Dannenfelser
Treatment of solid cancers with chimeric antigen receptor (CAR) T cells is plagued by the lack of target antigens that are both tumor-specific and homogeneously expressed. We show that multiantigen prime-and-kill recognition circuits have the flexibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18183e53b5f300c0e5f0cfd4adf01ba7
https://doi.org/10.1101/2021.01.07.425632
https://doi.org/10.1101/2021.01.07.425632
Autor:
Anna Celli, Nira A. Krasnow, Kira Downey, Jessica D. Briones, Wendell A. Lim, Sachdev S. Sidhu, Aileen li, Choe Joseph H, Wei Yu, Milos S. Simic, Ruth Dannenfelser, Hideho Okada, Lia Cardarelli, Payal Watchmaker, Diego Carrera, Juhyun Cho, Kole T. Roybal, Ryan Gilbert
Publikováno v:
Neuro Oncol
Treatment of solid cancers with chimeric antigen receptor (CAR) T-cells is challenging because of a lack of target antigens that are both tumor-specific and homogenously expressed. While epidermal growth factor receptor (EGFR)vIII represents a gliobl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc545364e712760df0b9976a391572a
https://doi.org/10.1093/neuonc/noaa215.463
https://doi.org/10.1093/neuonc/noaa215.463
Autor:
Hyun Ju, Lee, Alireza, Noormohammadi, Seda, Koyuncu, Giuseppe, Calculli, Milos S, Simic, Marija, Herholz, Aleksandra, Trifunovic, David, Vilchez
Publikováno v:
Nature metabolism
A moderate reduction of body temperature can induce a remarkable lifespan extension. Here we examine the link between cold temperature, germ line fitness and organismal longevity. We show that low temperature reduces age-associated exhaustion of germ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ca94032852fe8ab0abcf88780965d40
https://pubmed.ncbi.nlm.nih.gov/31485561
https://pubmed.ncbi.nlm.nih.gov/31485561
Autor:
Melissa Sanchez, Robert T. Schinzel, Dirk Hockemeyer, Milos S. Simic, Erica A. Moehle, Andrew Dillin, Franziska K. Lorbeer, Kartoosh Heydari, Damien Jullié, Jonathan Halloran
Publikováno v:
Science Advances
Science advances, vol 5, iss 4
Science advances, vol 5, iss 4
A transient activation of the unfolded protein response of the ER is a key factor of cellular reprogramming success.
Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires b
Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a0f74ac9c01453039daddc35dd2d6a
https://doi.org/10.1126/sciadv.aaw0025
https://doi.org/10.1126/sciadv.aaw0025
Autor:
Saranya Santhosh Kumar, Hannah Chi, Milos S. Simic, Phillip A. Frankino, Corinne Pender, Nupur Savalia, Erica A. Moehle, Ryo Higuchi-Sanabria, Andrew Dillin, Larry Joe, Brant Michael Webster, Naame Kelet, Robert T. Schinzel, Raz Bar-Ziv, Ngoc-Tram Nguyen, Jenni Durieux, Ophir Shalem
Publikováno v:
Cell. 179(6)
Summary Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPRER, which are strongly associated with several diseases and the aging process. We performed a whole-genome CRISPR-based knockout (KO) screen to identify gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a74bc95c5b6464281d7428b8b96b3d0
https://pubmed.ncbi.nlm.nih.gov/31801059
https://pubmed.ncbi.nlm.nih.gov/31801059