Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Milos Musil"'
Autor:
Milos Musil, Andrej Jezik, Marie Jankujova, Jan Stourac, Jakub Galgonek, Saltuk Mustafa Eyrilmez, Jiri Vondrasek, Jiri Damborsky, David Bednar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6512-6518 (2022)
Protein tunnels are essential in transporting small molecules into the active sites of enzymes. Tunnels' geometrical and physico-chemical properties influence the transport process. The tunnels are attractive hot spots for protein engineering and dru
Externí odkaz:
https://doaj.org/article/14aa7edb75b64030812052db2895149c
Autor:
Jan Velecký, Marie Hamsikova, Jan Stourac, Milos Musil, Jiri Damborsky, David Bednar, Stanislav Mazurenko
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6339-6347 (2022)
Protein solubility is an attractive engineering target primarily due to its relation to yields in protein production and manufacturing. Moreover, better knowledge of the mutational effects on protein solubility could connect several serious human dis
Externí odkaz:
https://doaj.org/article/01996fd690c34e7e8edd9de1f51b18d1
Autor:
Stefan Segla, Milos Musil
Publikováno v:
Tehnički Vjesnik, Vol 25, Iss 6, Pp 1659-1666 (2018)
In this paper modelling, control and optimization of a kinematically excited horizontal platform is presented. The platform with two independent mutually perpendicular suspension units is designed to mitigate horizontal vibration of the operator seat
Externí odkaz:
https://doaj.org/article/d3f98fd8767a40229a724fc63325cf8d
Autor:
Jan, Velecký, Marie, Hamsikova, Jan, Stourac, Milos, Musil, Jiri, Damborsky, David, Bednar, Stanislav, Mazurenko
Publikováno v:
Computational and structural biotechnology journal. 20
Protein solubility is an attractive engineering target primarily due to its relation to yields in protein production and manufacturing. Moreover, better knowledge of the mutational effects on protein solubility could connect several serious human dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c9c6dd6099add1906bc92e2cefb5b7f
https://pubmed.ncbi.nlm.nih.gov/36420168
https://pubmed.ncbi.nlm.nih.gov/36420168
Autor:
Jiri Damborsky, Stanislav Mazurenko, Jan Stourac, Milos Musil, Juraj Dubrava, David Bednar, Jana Horackova
Publikováno v:
Nucleic Acids Research
Nucleic acids research
Nucleic acids research
The majority of naturally occurring proteins have evolved to function under mild conditions inside the living organisms. One of the critical obstacles for the use of proteins in biotechnological applications is their insufficient stability at elevate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3248d5cf768809cdd5dd9dd905faa41a
http://europepmc.org/articles/PMC7778887
http://europepmc.org/articles/PMC7778887
Autor:
Jan Stourac, Tomáš Martínek, Jan Brezovsky, Jiri Damborsky, Jaroslav Zendulka, Zbynek Prokop, Jaroslav Bendl, Milos Musil, David Bednar
Publikováno v:
Nucleic Acids Research
There is a continuous interest in increasing proteins stability to enhance their usability in numerous biomedical and biotechnological applications. A number of in silico tools for the prediction of the effect of mutations on protein stability have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adf395b8526e405ead25da8b9f137f0
https://doi.org/10.1093/nar/gkx285
https://doi.org/10.1093/nar/gkx285
Autor:
David Bednar, Jan Stourac, Milos Musil, Joan Planas-Iglesias, Sérgio M. Marques, Gaspar Pinto, Jiri Damborsky
Publikováno v:
Biotechnology Advances. 47:107696
Enzymes are the natural catalysts that execute biochemical reactions upholding life. Their natural effectiveness has been fine-tuned as a result of millions of years of natural evolution. Such catalytic effectiveness has prompted the use of biocataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3daf1a8711d2225d8fc6d02f66574e6a
https://doi.org/10.1016/j.biotechadv.2021.107696
https://doi.org/10.1016/j.biotechadv.2021.107696
Publikováno v:
ACS Catalysis
Natural enzymes are delicate biomolecules possessing only marginal thermodynamic stability. Poorly stable, misfolded, and aggregated proteins lead to huge economic losses in the biotechnology and biopharmaceutical industries. Consequently, there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580d1026e9bc751e4a66518c522dab24
Autor:
Milos Musil, Martin Sivy
Publikováno v:
Proceedings of the 6th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering (COMPDYN 2015).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bee5dc9194d6a4a4f35949673594f03a
https://doi.org/10.7712/120117.5661.17061
https://doi.org/10.7712/120117.5661.17061
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 12, Iss 5, p e1004962 (2016)
PLoS Computational Biology, Vol 12, Iss 5, p e1004962 (2016)
An important message taken from human genome sequencing projects is that the human population exhibits approximately 99.9% genetic similarity. Variations in the remaining parts of the genome determine our identity, trace our history and reveal our he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7877970dbd7118ec4de63953156255c6
http://europepmc.org/articles/PMC4880439
http://europepmc.org/articles/PMC4880439