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Application of a stable-isotope dilution technique to study the pharmacokinetics of human 15N-labelled S-nitrosoalbumin in the rat: possible mechanistic and biological implications

Autor: Dirk O. Stichtenoth, Jörg Sandmann, Milos Ikic, Stefan Rossa, Dimitrios Tsikas, Piet Luessen, Athanasia Warnecke, Frank-Mathias Gutzki

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(13)

In the year 1992, S-nitrosoalbumin (SNALB) has been proposed to be the most abundant physiological carrier and pool of nitric oxide (NO) activity in human circulation, by which NO-dependent biological functions are regulated. The concentration, the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344a340e3974c1f44a94f075ef670859
https://pubmed.ncbi.nlm.nih.gov/19070554

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Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets

Autor: Manfred Raida, Dimitrios Tsikas, Jürgen C. Frölich, Kathrin S. Tewes, Milos Ikic

Publikováno v: FEBS letters. 442(2-3)

S-Nitroso-cysteine (SNC), a putative endothelium-derived relaxing factor, potently inhibited collagen- and arachidonic acid-induced platelet aggregation (IC50=100 nM) and thromboxane A2 (TxA2) synthesis of human blood platelets. ODQ, a selective inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99db6d26a33207721f4e5d2e0d00645
https://pubmed.ncbi.nlm.nih.gov/9928994

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Analysis of cysteine and N-acetylcysteine in human plasma by high-performance liquid chromatography at the basal state and after oral administration of N-acetylcysteine

Autor: Jürgen C. Frölich, Joachim Fauler, Milos Ikic, Dimitrios Tsikas, Dirk O. Stichtenoth, Jörg Sandmann

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 708(1-2)

A high-performance liquid chromatographic method for the determination of free reduced cysteine and N-acetylcysteine in human plasma at the basal state and after oral administration of N-acetylcysteine is described. The method is based on acid-cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7616ea48d768fd22e7386c7b09b2508f
https://pubmed.ncbi.nlm.nih.gov/9653946

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