Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Milos Aleksic"'
Autor:
Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering
Externí odkaz:
https://doaj.org/article/d2f84672e7fe4eb3b7df368784cf9d36
Autor:
Andrew Leishman, Wayne Paes, Emma Sparrow, Ana Ribeiro, Michael Cundell, Milos Aleksic, Michael P. Pinggera, Jessica Sette, Kate Anderton, Nicola Ternette, Juliet Morgan, Jason J. Shiers, Martin Quibell, Peter I. Joyce
Publikováno v:
Cancer Research. 83:3467-3467
Immune checkpoint inhibitors (ICI) have changed the cancer treatment paradigm, yet significant unmet need remains. Clinical data shows that increasing antigen presentation diversity, genomic instability, tumor mutational burden and HLA diversity, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d5bd330663d41c67cee96c805d7ad09
https://doi.org/10.1158/1538-7445.am2023-3467
https://doi.org/10.1158/1538-7445.am2023-3467
Autor:
Andrew, Poole, Vijaykumar, Karuppiah, Annabelle, Hartt, Jaafar N, Haidar, Sylvie, Moureau, Tomasz, Dobrzycki, Conor, Hayes, Christopher, Rowley, Jorge, Dias, Stephen, Harper, Keir, Barnbrook, Miriam, Hock, Charlotte, Coles, Wei, Yang, Milos, Aleksic, Aimee Bence, Lin, Ross, Robinson, Joe D, Dukes, Nathaniel, Liddy, Marc, Van der Kamp, Gregory D, Plowman, Annelise, Vuidepot, David K, Cole, Andrew D, Whale, Chandramouli, Chillakuri
Publikováno v:
Nature communications. 13(1)
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several cancers. Here we show the identification and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09b6f49fe5f2b3f9dd982b4e6d4e47e8
https://pubmed.ncbi.nlm.nih.gov/36088370
https://pubmed.ncbi.nlm.nih.gov/36088370
Autor:
Malkit Sami, Ben de Wet, Elizabeth A. Potter, Rory M. Crean, Katy A. Lloyd, Velupillai Srikannathasan, Nikolai Lissin, Milos Aleksic, Anitha Jeyanthan, Miriam Hock, David K. Cole, Peter Eamon Molloy, Pierre J. Rizkallah, Marco Lepore, Annelise Vuidepot, Christopher J. Holland, Brian Cameron, Thomas Blicher, Robert J. Pengelly, Christopher R. Pudney, Ross A. Robinson, Johanne M. Pentier, Thomas E. Spinner, Marc W. van der Kamp, Bent K. Jakobsen, Nathaniel Liddy, Paul J. Conroy, Stephen Harper, Angharad Lloyd
Publikováno v:
J Clin Invest
Tumor-associated peptide-human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface-expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbe9e3e9f83c5de1920113bed8d5316
https://europepmc.org/articles/PMC7190993/
https://europepmc.org/articles/PMC7190993/
Autor:
M Kristina Stancic, B Milos Aleksic
Publikováno v:
Politeia, Vol 7, Iss 13, Pp 154-167 (2017)
This paper provides a critical, comparative analysis of the newspaper articles of the daily Politika, from 1904 and 1929, with the emphasis on the importance of political, historical and social factors in their interpretation. Also, this paper stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2a339c817abe52d6c431617b25f4d7
https://doi.org/10.5937/pol1713154s
https://doi.org/10.5937/pol1713154s
Autor:
Milos Aleksic, Joanne Oates, Peter Eamon Molloy, Annelise Vuidepot, Giovanna Bossi, Namir J. Hassan, Gemma Hancock, Tara Mahon, Hongbing Yang, Sandrine Buisson, Lucy Dorrell, Rebecca Ashfield, Samantha Paston, Zoë Wallace, Chun So, Bent K. Jakobsen
Publikováno v:
Molecular Therapy. 24(11):1913-1925
Persistence of human immunodeficiency virus (HIV) in a latent state in long-lived CD4+ T-cells is a major barrier to eradication. Latency-reversing agents that induce direct or immune-mediated cell death upon reactivation of HIV are a possible soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2a52d8aa742ee32d2c92c733527472
Autor:
Hong-Sheng Lim, Milos Aleksic, P. Anton van der Merwe, Charlotte M. Deane, Hao Zhang, Berhard Knapp, Omer Dushek
Publikováno v:
Scientific Reports
The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49bee2693b230407d3f28437781a853
https://ora.ox.ac.uk/objects/uuid:8cf144ca-5766-4bf1-b2c0-f59a3fbce3b3
https://ora.ox.ac.uk/objects/uuid:8cf144ca-5766-4bf1-b2c0-f59a3fbce3b3
Autor:
Milos Aleksic, Nick Pumphrey, Annelise Vuidepot, Nathaniel Liddy, Kyong-Mi Chang, Peter Eamon Molloy, Bent K. Jakobsen
Publikováno v:
European Journal of Immunology. 42:3174-3179
T-cell destiny during thymic selection depends on the affinity of the TCR for autologous peptide ligands presented in the context of MHC molecules. This is a delicately balanced process; robust binding leads to negative selection, yet some affinity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223683c6a998c001868428a7036882c6
https://doi.org/10.1002/eji.201242606
https://doi.org/10.1002/eji.201242606
Autor:
Eugene Shenderov, Daniel Coombs, Hao Zhang, Vincenzo Cerundolo, Ji Li Chen, Omer Dushek, P. Anton van der Merwe, Milos Aleksic
Publikováno v:
Immunity
Summary T cell receptor (TCR) binding to diverse peptide-major histocompatibility complex (pMHC) ligands results in various degrees of T cell activation. Here we analyze which binding properties of the TCR-pMHC interaction are responsible for this va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132dc90f6a8c8f4b5dd8f165523f9fbf
http://europepmc.org/articles/PMC2862301
http://europepmc.org/articles/PMC2862301
Autor:
Angelina Hausauer, Rebecca Berger, Katharina Hess, Nikolaus Marx, Daniel Walcher, Renate Durst, Milos Aleksic, Vinzenz Hombach, Philipp Heinz, Helga Bach
Publikováno v:
Cardiovascular Research. 85:167-174
Aims Increased levels of resistin, a peptide secreted by adipocytes and inflammatory cells, circulate in patients with insulin resistance and early type 2 diabetes, a high-risk population for the development of a diffuse and extensive pattern of arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87c38a515b0fdcb2cab07f87d49fb76
https://doi.org/10.1093/cvr/cvp278
https://doi.org/10.1093/cvr/cvp278