Zobrazeno 1 - 10
of 1 251
pro vyhledávání: '"Milo S"'
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract As organisms evolve, the effects of mutations change as a result of epistatic interactions with other mutations accumulated along the line of descent. This can lead to shifts in adaptability or robustness that ultimately shape subsequent evo
Externí odkaz:
https://doaj.org/article/32a1556719d3467f994dfe2d3cae345e
Autor:
Vivian Chen, Milo S Johnson, Lucas Hérissant, Parris T Humphrey, David C Yuan, Yuping Li, Atish Agarwala, Samuel B Hoelscher, Dmitri A Petrov, Michael M Desai, Gavin Sherlock
Publikováno v:
eLife, Vol 12 (2023)
Adaptation is driven by the selection for beneficial mutations that provide a fitness advantage in the specific environment in which a population is evolving. However, environments are rarely constant or predictable. When an organism well adapted to
Externí odkaz:
https://doaj.org/article/9c44f59c73d9493fa1e4d3757e09ecb5
Autor:
Milo S Johnson, Michael M Desai
Publikováno v:
eLife, Vol 11 (2022)
As an adapting population traverses the fitness landscape, its local neighborhood (i.e., the collection of fitness effects of single-step mutations) can change shape because of interactions with mutations acquired during evolution. These changes to t
Externí odkaz:
https://doaj.org/article/f471106a9d7b4dd69ac002a62e392592
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
Structural energy storage devices (SESDs), designed to simultaneously store electrical energy and withstand mechanical loads, offer great potential to reduce the overall system weight in applications such as automotive, aircraft, spacecraft, marine a
Externí odkaz:
https://doaj.org/article/c9d712c684af467ea5a70430e35ee05d
Autor:
Angela M Phillips, Katherine R Lawrence, Alief Moulana, Thomas Dupic, Jeffrey Chang, Milo S Johnson, Ivana Cvijovic, Thierry Mora, Aleksandra M Walczak, Michael M Desai
Publikováno v:
eLife, Vol 10 (2021)
Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains have been isolated. Structural and biochemical characterization of these bnAbs has provided molecular insight into how
Externí odkaz:
https://doaj.org/article/a52f4aaca9534b4cbaabd27a7b983cb0
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations
Autor:
Milo S Johnson, Shreyas Gopalakrishnan, Juhee Goyal, Megan E Dillingham, Christopher W Bakerlee, Parris T Humphrey, Tanush Jagdish, Elizabeth R Jerison, Katya Kosheleva, Katherine R Lawrence, Jiseon Min, Alief Moulana, Angela M Phillips, Julia C Piper, Ramya Purkanti, Artur Rego-Costa, Michael J McDonald, Alex N Nguyen Ba, Michael M Desai
Publikováno v:
eLife, Vol 10 (2021)
Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we evolved 205 Saccharomyces cerevisiae populations (124 haploid and 81 diploid) for ~10,000 ge
Externí odkaz:
https://doaj.org/article/e8d8f2f76fba43eeaf3f7eae82f045e8
Autor:
Theo A. M. Suter, Adam J. Clancy, Noelia Rubio Carrero, Marie Heitzmann, Laure Guetaz, Paul R. Shearing, Cecilia Mattevi, Gérard Gebel, Christopher A. Howard, Milo S. P. Shaffer, Paul F. McMillan, Dan J. L. Brett
Publikováno v:
Nanomaterials, Vol 11, Iss 10, p 2530 (2021)
Polymer electrolyte fuel cells hold great promise for a range of applications but require advances in durability for widespread commercial uptake. Corrosion of the carbon support is one of the main degradation pathways; hence, corrosion-resilient gra
Externí odkaz:
https://doaj.org/article/e39a640b71304d468223ef60e41bdc09
Autor:
Elitza Karadotcheva, Sang N. Nguyen, Emile S. Greenhalgh, Milo S. P. Shaffer, Anthony R. J. Kucernak, Peter Linde
Publikováno v:
Energies, Vol 14, Iss 19, p 6006 (2021)
The development of commercial aviation is being driven by the need to improve efficiency and thereby lower emissions. All-electric aircraft present a route to eliminating direct fuel burning emissions, but their development is stifled by the limitati
Externí odkaz:
https://doaj.org/article/74b3804c09fa466d821862e53476e924
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Ligands and surfactants play an important part in the synthesis of nanoparticles from molecular precursors although their exact roles are poorly understood. Here, the authors isolate a range of intermediate sized zinc clusters and are able to spectro
Externí odkaz:
https://doaj.org/article/2459f720b21f4c66a23ea80d0d571a46
Autor:
Sandeep K. Sehmi, Sacha Noimark, Sebastian D. Pike, Joseph C. Bear, William J. Peveler, Charlotte K. Williams, Milo S. P. Shaffer, Elaine Allan, Ivan P. Parkin, Alexander J. MacRobert
Publikováno v:
ACS Omega, Vol 1, Iss 3, Pp 334-343 (2016)
Externí odkaz:
https://doaj.org/article/dbef1c2bcc2c4ba09b52a004e55d0da8