Výsledky vyhledávání - "Milly S. Pau"

The Intracellular Loop 2 F328S Frizzled-4 Mutation Implicated in Familial Exudative Vitreoretinopathy Impairs Dishevelled Recruitment

Autor: Shujuan Gao, Milly S. Pau, Alexander C. Bertalovitz, Hsien-yu Wang, Craig C. Malbon

Publikováno v: Journal of Molecular Signaling

Familial exudative vitreoretinopathy (FEVR) is a disease state characterized by aberrant retinal angiogenesis. Norrin-induced activation of Frizzled-4 (Fz4) has a major role in regulating beta-catenin levels in the eye that, in turn, modulate the blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054b64eee3e4535a704e66aa20d54148
https://pubmed.ncbi.nlm.nih.gov/27096003

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Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation

Autor: Shujuan Gao, Alexander C. Bertalovitz, Milly S. Pau, Hsien-yu Wang, Craig C. Malbon

Publikováno v: Journal of Molecular Signaling; Vol 11 (2016); 1
Journal of Molecular Signaling

The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7be53dbb36f653dc35055b1637d7834
http://www.jmolecularsignaling.com/jms/article/view/1750-2187-11-1

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