Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Millie M. Georgiadis"'
Autor:
Silpa Gampala, Hye-ran Moon, Randall Wireman, Jacqueline Peil, Sonia Kiran, Dana K. Mitchell, Kylee Brewster, Henry Mang, Andi Masters, Christine Bach, Whitney Smith-Kinnamen, Emma H. Doud, Ratan Rai, Amber L. Mosley, Sara K. Quinney, D. Wade Clapp, Chafiq Hamdouchi, James Wikel, Chi Zhang, Bumsoo Han, Millie M. Georgiadis, Mark R. Kelley, Melissa L. Fishel
Publikováno v:
Pharmacological Research, Vol 201, Iss , Pp 107092- (2024)
AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Ref-1) is a multifunctional protein that is overexpressed in most aggressive cancers and impacts various cancer cell signaling pathways. Ref-1′s redox activity plays a significant role in activating t
Externí odkaz:
https://doaj.org/article/aab80d4f3cdf4047a242a19cd4eadd78
Autor:
Joseph D. Racca, Deepak Chatterjee, Yen-Shan Chen, Ratan K. Rai, Yanwu Yang, Millie M. Georgiadis, Elisha Haas, Michael A. Weiss
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This factor contains a high-mobility-group (HMG) box, which mediates sequence-specific DNA binding with sharp DNA bending. A companion article in this issue describ
Externí odkaz:
https://doaj.org/article/b100fc8439af4539b9f3a1c25f9920c3
Autor:
Victor J. Anciano Granadillo, Jennifer N. Earley, Sarah C. Shuck, Millie M. Georgiadis, Richard W. Fitch, John J. Turchi
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Replication protein A (RPA) is the main eukaryotic single-strand (ss) DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs) that show in vitro inhibition of the RP
Externí odkaz:
https://doaj.org/article/105fba2e831342b5a65de6130732dac8
Publikováno v:
Journal of the American Chemical Society. 144:15603-15611
A fundamental property of DNA built from four informational nucleotide units (GCAT) is its ability to adopt different helical forms within the context of the Watson-Crick pair. Well-characterized examples include A-, B-, and Z-DNA. For this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9591c27eb10ceab08e3c9484b1c297e
https://doi.org/10.1021/jacs.2c05255
https://doi.org/10.1021/jacs.2c05255
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
The first structural model of duplex DNA reported in 1953 by Watson & Crick presented the double helix in B-form, the form that genomic DNA exists in much of the time. Thus, artificial DNA seeking to mimic the properties of natural DNA should also be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b33ed228dffffec5b46ab9448d8bf6
https://doi.org/10.1098/rstb.2022.0028
https://doi.org/10.1098/rstb.2022.0028
Publikováno v:
Acta Crystallogr D Struct Biol
Multicopper oxidases (MCOs) represent a diverse family of enzymes that catalyze the oxidation of either an organic or a metal substrate with concomitant reduction of dioxygen to water. These enzymes contain variable numbers of cupredoxin domains, two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1a30648a9098672b60fa6a77e2698c
https://doi.org/10.1107/s205979832100944x
https://doi.org/10.1107/s205979832100944x
Publikováno v:
Bioorganicmedicinal chemistry. 77
Bleomycins constitute a family of anticancer natural products that bind DNA through intercalation of a C-terminal tail/bithiazole moiety and hydrogen-bonding interactions between the remainder of the drug and the minor groove. The clinical utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d925d3cef5bc75bea7f25c5d173183f
https://pubmed.ncbi.nlm.nih.gov/36516684
https://pubmed.ncbi.nlm.nih.gov/36516684
Autor:
Siddhi Chitre, Anne-Marie Ray, Mckayla Stevens, Emma H. Doud, Hope Liechty, Alex Washburn, Katelyn Tepper, Jared Sivinski, Heather M. O'Hagan, Millie M. Georgiadis, Eli Chapman, Steven M. Johnson
Publikováno v:
Bioorganicmedicinal chemistry. 75
While many studies have established the importance of protein homeostasis in tumor progression, little effort has been made to examine the therapeutic potential of targeting the HSP60 chaperonin system. In healthy cells, HSP60 is localized to the mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64170a8200acc1dcd918dae6bc00628
https://pubmed.ncbi.nlm.nih.gov/36356534
https://pubmed.ncbi.nlm.nih.gov/36356534
Publikováno v:
Journal of Biological Chemistry. 299:104595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c153ac70cd42a2fcbed1546e3b021f3c
https://doi.org/10.1016/j.jbc.2023.104595
https://doi.org/10.1016/j.jbc.2023.104595
Publikováno v:
The Journal of Biological Chemistry
DNA polymerases are today used throughout scientific research, biotechnology, and medicine, in part for their ability to interact with unnatural forms of DNA created by synthetic biologists. Here especially, natural DNA polymerases often do not have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac08dee4cd2fbcbcb08bf7483a6200
https://doi.org/10.1074/jbc.rev120.013745
https://doi.org/10.1074/jbc.rev120.013745