Etude fonctionnelle du métabolisme de l'acétyl-CoA chez Trypanosoma brucei

Autor: Millerioux, Yoann

Trypanosoma brucei, parasite protozoaire flagellé appartenant à l’ordre des kinétoplastidés, est responsable de la maladie du sommeil, ou trypanosomiase humaine africaine (THA). Son cycle de vie fait intervenir un insecte vecteur hématophage (

Externí odkaz: http://www.theses.fr/2013BOR22114/document

De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions.

Autor: Millerioux, Yoann¹, Mazet, Muriel¹, Bouyssou, Guillaume², Allmann, Stefan¹, Kiema, Tiila-Riikka³, Bertiaux, Eloïse⁴, Fouillen, Laetitia^2,5, Thapa, Chandan³, Biran, Marc⁶, Plazolles, Nicolas¹, Dittrich-Domergue, Franziska², Crouzols, Aline⁴, Wierenga, Rik K.³, Rotureau, Brice⁴, Moreau, Patrick², Bringaud, Frédéric¹ frederic.bringaud@u-bordeaux.fr

Publikováno v: PLoS Pathogens. 5/29/2018, Vol. 14 Issue 5, p1-31. 31p.

Gluconeogenesis is essential for trypanosome development in the tsetse fly vector

Autor: Wargnies, Marion, Bertiaux, Eloise, Cahoreau, Edern, Ziebart, Nicole, Crouzols, Aline, Morand, Pauline, Biran, Marc, Allmann, Stefan, Hubert, Jane, Villafraz, Oriana, Millerioux, Yoann, Plazolles, Nicolas, Asencio, Corinne, Rivière, Loïc, Rotureau, Brice, Boshart, Michael, Portais, Jean-Charles, Bringaud, Frédéric

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2018, 14 (12), pp.e1007502. ⟨10.1371/journal.ppat.1007502⟩
PLoS Pathogens, Public Library of Science, 2018, 14 (12), pp.e1007502. ⟨10.1371/journal.ppat.1007502⟩
Plos Pathogens 12 (14), 28 p.. (2018)
PLoS Pathogens, Vol 14, Iss 12, p e1007502 (2018)

In the glucose-free environment that is the midgut of the tsetse fly vector, the procyclic form of Trypanosoma brucei primarily uses proline to feed its central carbon and energy metabolism. In these conditions, the parasite needs to produce glucose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e78bc6ed03e245c970adcf2eddadbbd
https://hal-pasteur.archives-ouvertes.fr/pasteur-01963538/file/journal.ppat.1007502.pdf

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

Autor: Creek, Darren J., Mazet, Muriel, Achcar, Fiona, Anderson, Jana, Kim, Dong-Hyun, Kamour, Ruwida, Morand, Pauline, Millerioux, Yoann, Biran, Marc, Kerkhoven, Eduard J., Chokkathukalam, Achuthanunni, Weidt, Stefan K., Burgess, Karl E.V., Breitling, Rainer, Watson, David G., Bringaud, Frédéric, Barrett, Michael

Publikováno v: PLoS Pathogens, Vol 11, Iss 3, p e1004689 (2015)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2015, 11 (3), pp.e1004689. ⟨10.1371/journal.ppat.1004689⟩
Creek, D J, Mazet, M, Achcar, F, Anderson, J, Kim, D H, Kamour, R, Morand, P, Millerioux, Y, Biran, M, Kerkhoven, E J, Chokkathukalam, A, Weidt, S K, Burgess, K E V, Breitling, R, Watson, D G, Bringaud, F & Barrett, M P 2015, ' Probing the metabolic network in bloodstream-form trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose ', PLoS Pathogens, vol. 11, no. 3, e1004689, pp. 1-25 . https://doi.org/10.1371/journal.ppat.1004689
PLoS Pathogens, 2015, 11 (3), pp.e1004689. ⟨10.1371/journal.ppat.1004689⟩

Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d8cbcfa5639a0397226a01cdbef438f3
https://doaj.org/article/6f5a415b91f34ce6b29b7e4fca138d7b

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