Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.

Autor: Bauman AA; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Sarathy JP; Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Nutley, New Jersey, USA., Kaya F; Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Nutley, New Jersey, USA., Massoudi LM; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Scherman MS; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Hastings C; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Liu J; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Xie M; Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Nutley, New Jersey, USA., Brooks EJ; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Ramey ME; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Jones IL; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Benedict ND; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Maclaughlin MR; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Miller-Dawson JA; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Waidyarachchi SL; Microbiotix, Inc., Worcester, Massachusetts, USA., Butler MM; Microbiotix, Inc., Worcester, Massachusetts, USA., Bowlin TL; Microbiotix, Inc., Worcester, Massachusetts, USA., Zimmerman MD; Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Nutley, New Jersey, USA., Lenaerts AJ; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Meibohm B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA., Gonzalez-Juarrero M; Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Nutley, New Jersey, USA., Lyons MA; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA., Dartois V; Hackensack Meridian School of Medicine, Center for Discovery and Innovation, Nutley, New Jersey, USA., Lee RE; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Robertson GT; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Nov 06; Vol. 68 (11), pp. e0071624. Date of Electronic Publication: 2024 Sep 30.

Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.

Autor: Ramey ME; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Kaya F; Center for Discovery and Innovation, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA., Bauman AA; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Massoudi LM; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Sarathy JP; Center for Discovery and Innovation, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA., Zimmerman MD; Center for Discovery and Innovation, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA., Scott DWL; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Job AM; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Miller-Dawson JA; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Podell BK; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Lyons MA; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Dartois V; Center for Discovery and Innovation, Hackensack Meridian School of Medicine , Nutley, New Jersey, USA., Lenaerts AJ; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA., Robertson GT; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University , Fort Collins, Colorado, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Nov 15; Vol. 67 (11), pp. e0059723. Date of Electronic Publication: 2023 Oct 04.