Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Miller Stephan S"'
Autor:
Matthew Jarpe, You Li, John Eldredge, Herman W. T. van Vlijmen, P. Ann Boriack-Sjodin, Louis A. Clark, Eric S. Day, Miller Stephan S, Christopher Fitch, Kenneth Simon
Publikováno v:
Protein Engineering Design and Selection. 22:93-101
A design approach was taken to investigate the feasibility of replacing single complementarity determining region (CDR) antibody loops. This approach may complement simpler mutation-based strategies for rational antibody design by expanding conformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9948bdc9d84c42cab84093220aca88
https://doi.org/10.1093/protein/gzn072
https://doi.org/10.1093/protein/gzn072
Autor:
Stefano F. Liparoto, John Eldredge, You Li, Christopher Fitch, Mia Rushe, Alexey Lugovskoy, Karl J. M. Hanf, Matthew Jarpe, Herman W. T. van Vlijmen, Woody Sherman, Kenneth Simon, Louis A. Clark, P. Ann Boriack-Sjodin, Miller Stephan S, Bethany Friedman
Publikováno v:
Protein Science. 15:949-960
Improving the affinity of a high-affinity protein-protein interaction is a challenging problem that has practical applications in the development of therapeutic biomolecules. We used a combination of structure-based computational methods to optimize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e85270373cb16f8b1af9a0192a5a136
https://doi.org/10.1110/ps.052030506
https://doi.org/10.1110/ps.052030506
Autor:
Olivia Orozco, Paul Carmillo, Dane S. Worley, Carolyn Buckley, Lee Walus, Richard L. Cate, Carl Rosenblad, Anthony Rossomando, Lone Dagø, Dinah W. Y. Sah, Miller Stephan S, Albert Tse, Eric S. Day, Mette Grønborg, Adrian Whitty
Publikováno v:
Biochemistry. 44:2545-2554
To clarify whether glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFRalpha1), the glycosylphosphatidylinositol (GPI)-linked coreceptor for GDNF, is also a functional coreceptor for artemin (ART), we have studied receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bfbe89baa46a494402500af31bc74f
https://doi.org/10.1021/bi049247p
https://doi.org/10.1021/bi049247p
Autor:
Miller Stephan S, Zhifang Li, Alan Rapoza, Darren P. Baker, Matthew Betzenhauser, Jeannine Delaney, Caroline Coots, Dingyi Wen, Azita Kaffashan, Bruno Domon, Raymond E. Boynton, Ling Ling Chen, Alan Gill, Carmen N. Young, Nelly Viseux, Liqing Chen, Konrad Miatkowski, Hess Donna M, Paula S. Hochman, Robert S. Gronke, Robert M. Arduini, R. Blake Pepinsky
Publikováno v:
Protein Expression and Purification. 34:229-242
To identify potential new clinical uses and routes of administration for human interferon-beta-1a (IFN-beta-1a), we have developed an expression and purification procedure for the preparation of highly purified rat interferon-beta (IFN-beta) suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681c84dd263ebd5ab5bb92feaf711c21
https://doi.org/10.1016/j.pep.2003.11.004
https://doi.org/10.1016/j.pep.2003.11.004
Autor:
Albert Tse, Lee Walus, Richard L. Cate, Ruizhong Wang, Todd W. Vanderah, Bang Jian Gong, Frank Porreca, Luis R. Gardell, Thomas Engber, Dane S. Worley, Anthony Rossomando, Pepinsky R Blake, Chris Ehrenfels, Dinah W. Y. Sah, Miller Stephan S, Josephine Lai, Carol Huang, Carolyn Buckley, Amber K. Cai, Michael H. Ossipov, Paul Carmillo, Susan F. Foley
Publikováno v:
Nature medicine. 9(11)
The clinical management of neuropathic pain is particularly challenging. Current therapies for neuropathic pain modulate nerve impulse propagation or synaptic transmission; these therapies are of limited benefit and have undesirable side effects. Inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4eaf5b8849ac55fbafd14a75842bdf
https://pubmed.ncbi.nlm.nih.gov/14595426
https://pubmed.ncbi.nlm.nih.gov/14595426
Autor:
Darren P. Baker, Carole de Dios, Zhifang Li, Celine Muldowney, Paula S. Hochman, Matthew Betzenhauser, Sidney E. Grossberg, Miller Stephan S, Philip N. Redlich, Laura Runkel, Michael Karpusas, Adrian Whitty, Mohammad Zafari
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 21(11)
The epitopes important for receptor binding and activation of human interferon-beta1a (IFN-beta1a) were mapped with monoclonal antibodies (mAb), grouped on the basis of their specificity and ability to neutralize biologic activity, and alanine scanni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59e2fef4969aa29a93644da78e8c405
https://pubmed.ncbi.nlm.nih.gov/11747625
https://pubmed.ncbi.nlm.nih.gov/11747625
Autor:
Matthew Betzenhauser, Paula S. Hochman, Miller Stephan S, Mohammad Zafari, Laura Runkel, Celine Muldowney, Michael Karpusas, Adrian Whitty, Christopher D. Benjamin, Carole deDios
Publikováno v:
Biochemistry. 39(10)
A systematic mutational analysis of human interferon-beta-1a (IFN-beta) was performed to identify regions on the surface of the molecule that are important for receptor binding and for functional activity. The crystal structure of IFN-beta-1a was use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6d4082370ddf37ff8ae13dbf3c2d3a
https://pubmed.ncbi.nlm.nih.gov/10704203
https://pubmed.ncbi.nlm.nih.gov/10704203