Výsledky vyhledávání - "Miller Donald M"

Akademický článek

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

Autor: Telang Sucheta, Rasku Mary, Clem Amy L, Carter Karen, Klarer Alden C, Badger Wesley R, Milam Rebecca A, Rai Shesh N, Pan Jianmin, Gragg Hana, Clem Brian F, McMasters Kelly M, Miller Donald M, Chesney Jason

Publikováno v: BMC Cancer, Vol 11, Iss 1, p 515 (2011)

Abstract Background We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4+CD25HIFoxp3+ regulatory T cells and expanded melanoma-specific

Externí odkaz: https://doaj.org/article/bd9ace9db12d418c836f8e2838b839ca

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Akademický článek

Hypoxia induces differential translation of enolase/MBP-1

Autor: Miller Donald M, Thomas Shelia D, Sedoris Kara C

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 157 (2010)

Abstract Background Hypoxic microenvironments in tumors contribute to transformation, which may alter metabolism, growth, and therapeutic responsiveness. The α-enolase gene encodes both a glycolytic enzyme (α-enolase) and a DNA-binding tumor suppre

Externí odkaz: https://doaj.org/article/bf16377160094d17ab9577a243be501f

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Akademický článek

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

Autor: Higashi Richard M, Lane Andrew N, Fan Teresa WM, Farag Mohamed A, Gao Hong, Bousamra Michael, Miller Donald M

Publikováno v: Molecular Cancer, Vol 8, Iss 1, p 41 (2009)

Abstract Background Metabolic perturbations arising from malignant transformation have not been systematically characterized in human lung cancers in situ. Stable isotope resolved metabolomic analysis (SIRM) enables functional analysis of gene dysreg

Externí odkaz: https://doaj.org/article/f098e6b7940e407fbe7b5e598cc9ff20

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Akademický článek

Transient T cell depletion causes regression of melanoma metastases

Autor: Lear Sheron C, Cramer Daniel, Gragg Hana, Gettings Kelly, Taft Beverly, Telang Sucheta, Clem Amy L, Rasku Mary, McMasters Kelly M, Miller Donald M, Chesney Jason

Publikováno v: Journal of Translational Medicine, Vol 6, Iss 1, p 12 (2008)

Abstract Background Cognate immunity against neoplastic cells depends on a balance between effector T cells and regulatory T (Treg) cells. Treg cells prevent immune attack against normal and neoplastic cells by directly suppressing the activation of

Externí odkaz: https://doaj.org/article/c74da2aee6de456fa47a5d8973cdfe70

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