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Absence of ABL1exon 2-encoded SH3 residues in BCR::ABL1destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

Autor: Leyte-Vidal, Ariel, DeFilippis, RosaAnna, Outhwaite, Ian R., Kwan, Isabelle, Lee, Ji Young, Leavitt, Carlyn, Miller, Kaeli B., Rea, Delphine, Rangwala, Aziz M., Lou, Kevin, Patel, Suhana, Alvarez, Ailin, Shokat, Kevan M., Bahar, Ivet, Seeliger, Markus A., Shah, Neil P.

Publikováno v: Leukemia; 20240101, Issue: Preprints p1-5, 5p

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.

Autor: Leyte-Vidal A; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA., DeFilippis R; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Outhwaite IR; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Kwan I; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Lee JY; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA., Leavitt C; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Miller KB; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Rea D; Adult Hematology Department, Hôpital Saint-Louis, Paris, France., Rangwala AM; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Lou K; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA., Patel S; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Alvarez A; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA.; Department of Chemistry, University of California, Berkeley, CA, 94720, USA., Bahar I; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Seeliger MA; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA., Shah NP; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA. neil.shah@ucsf.edu.

Publikováno v: Leukemia [Leukemia] 2024 Sep; Vol. 38 (9), pp. 2046-2050. Date of Electronic Publication: 2024 Jul 31.