Early rhombic lip Protogenin ^+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma.

Autor: Visvanathan A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Saulnier O; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Genomics and Development of Childhood Cancers, Institut Curie, PSL University, 75005 Paris, France; INSERM U830, Cancer Heterogeneity Instability and Plasticity, Institut Curie, PSL University, 75005 Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, 75005 Paris, France., Chen C; Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Haldipur P; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Orisme W; St. Jude Children's Research Hospital, Memphis, TN, USA., Delaidelli A; British Columbia Cancer Agency, Vancouver, BC, Canada., Shin S; Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Millman J; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Bryant A; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Abeysundara N; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Wu X; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Hendrikse LD; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Patil V; MacFeeters-Hamilton Center for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Bashardanesh Z; Lady Davis Institute, McGill University, Montreal, QC, Canada., Golser J; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Livingston BG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Nakashima T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Funakoshi Y; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Ong W; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Rasnitsyn A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Aldinger KA; Departments of Pediatrics and Neurology. University of Washington, Seattle, WA, USA., Richman CM; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Van Ommeren R; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Lee JJY; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Ly M; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Vladoiu MC; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Kharas K; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Balin P; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Erickson AW; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Fong V; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Zhang J; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA., Suárez RA; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Wang H; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Huang N; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Pallota JG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Douglas T; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Haapasalo J; Department of Neurosurgery, Tampere University Hospital, Tampere, Finland., Razavi F; Assistance Publique Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France., Silvestri E; Surgical Pathology Unit, San Camillo Forlanini Hospital, Rome, Italy., Sirbu O; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Worme S; Division of Experimental Medicine, McGill University, Montreal, QC, Canada., Kameda-Smith MM; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA., Wu X; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA., Daniels C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA., MichaelRaj AK; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bhaduri A; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Suzuki H; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Garzia L; Cancer Research Program, McGill University Health Centre Research Institute, Montreal, QC, Canada., Ahmed N; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Kleinman CL; Department of Human Genetics, McGill University, Montreal, QC, Canada; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada., Stein LD; Adaptive Oncology, Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Dirks P; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada., Dunham C; British Columbia Children's Hospital, Vancouver, BC, Canada., Jabado N; Departments of Pediatrics and Human Genetics, McGill University, Montreal, QC, Canada; The Research Institute of the McGill University Health Center, Montreal, QC, Canada., Rich JN; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Li W; Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sorensen PH; British Columbia Cancer Agency, Vancouver, BC, Canada., Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Weiss WA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Millen KJ; Department of Pediatrics, University of Washington, Seattle, USA., Ellison DW; St. Jude Children's Research Hospital, Memphis, TN, USA., Dimitrov DS; Center for Antibody Therapeutics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: mit666666@pitt.edu., Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Texas Children's Cancer and Hematology Center, Houston, TX, USA; Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Texas Children's Hospital, Houston, TX, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Department of Surgery, University of Toronto, Toronto, ON, Canada. Electronic address: mdt.cns@gmail.com.

Publikováno v: Cell [Cell] 2024 Aug 22; Vol. 187 (17), pp. 4733-4750.e26. Date of Electronic Publication: 2024 Jul 05.

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.

Autor: Stock AJ; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology, Oklahoma City, OK, United States., Gonzalez Paredes P; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology, Oklahoma City, OK, United States., de Almeida LP; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology, Oklahoma City, OK, United States., Kosanke SD; Heartland Veterinary Pathology Services, PLLC, Edmond, OK, United States., Chetlur S; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology, Oklahoma City, OK, United States., Budde H; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology, Oklahoma City, OK, United States., Wakenight P; Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, United States., Zwingman TA; Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, United States., Rosen ABI; Seattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, United States., Allenspach EJ; Seattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, United States.; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, United States., Millen KJ; Seattle Children's Research Institute, Center for Integrative Brain Research, Seattle, WA, United States.; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, United States., Buckner JH; Benaroya Research Institute at Virginia Mason, Center for Translational Immunology, Seattle, WA, United States., Rawlings DJ; Seattle Children's Research Institute, Center for Immunity and Immunotherapies, Seattle, WA, United States.; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, United States.; Department of Immunology, School of Medicine, University of Washington, Seattle, WA, United States., Gorman JA; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology, Oklahoma City, OK, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Feb 29; Vol. 15, pp. 1349601. Date of Electronic Publication: 2024 Feb 29 (Print Publication: 2024).

Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus).

Autor: Nguyen ED; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195, USA., Fard VN; School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ 86011, USA., Kim BY; Department of Biology, Stanford University, Stanford, CA 94305, USA., Collins S; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA., Galey M; Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA 98195, USA., Nelson BR; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA., Wakenight P; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA., Gable SM; School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ 86011, USA., McKenna A; Department of Molecular & Systems Biology, Dartmouth Geisel School of Medicine, Lebanon, NH 03755, USA., Bammler TK; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA., MacDonald J; Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA., Okamura DM; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA., Shendure J; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195, USA.; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA.; Institute of Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98195, USA., Beier DR; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA., Ramirez JM; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.; Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA., Majesky MW; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Center for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA.; Institute of Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA 98195, USA., Millen KJ; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195, USA.; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA., Tollis M; School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ 86011, USA., Miller DE; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195, USA.; Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA 98195, USA.

Publikováno v: G3 (Bethesda, Md.) [G3 (Bethesda)] 2023 Sep 30; Vol. 13 (10).

Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation.

Autor: Hendrikse LD; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Haldipur P; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Saulnier O; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Millman J; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Sjoboen AH; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Erickson AW; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Ong W; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Gordon V; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Coudière-Morrison L; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Mercier AL; PSL Research University, Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Institut Curie, Orsay, France., Shokouhian M; Department of Pediatrics and Child Health and Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Suárez RA; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Ly M; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Borlase S; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Scott DS; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Vladoiu MC; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Farooq H; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Sirbu O; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Nakashima T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Nambu S; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Funakoshi Y; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Bahcheli A; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Diaz-Mejia JJ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Golser J; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Bach K; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Phuong-Bao T; Department of Pediatrics and Child Health and Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Skowron P; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Wang EY; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Kumar SA; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Balin P; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Visvanathan A; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Lee JJY; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Ayoub R; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Chen X; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Chen X; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Mungall KL; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada., Luu B; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Bérubé P; McGill University Genome Centre, McGill University, Montreal, Quebec, Canada., Wang YC; McGill University Genome Centre, McGill University, Montreal, Quebec, Canada., Pfister SM; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany., Kim SK; Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, South Korea., Delattre O; SIREDO Oncology Center (Pediatric, Adolescent and Young Adults Oncology), Institut Curie, Paris, France.; INSERM U830, Institut Curie, Paris, France., Bourdeaut F; SIREDO Oncology Center (Pediatric, Adolescent and Young Adults Oncology), Institut Curie, Paris, France.; INSERM U830, Institut Curie, Paris, France., Doz F; SIREDO Oncology Center (Pediatric, Adolescent and Young Adults Oncology), Institut Curie, Paris, France.; Université Paris Cité, Paris, France., Masliah-Planchon J; Unit of Somatic Genetics, Institut Curie, Paris, France., Grajkowska WA; Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland., Loukides J; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Dirks P; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada., Fèvre-Montange M; INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences, Université de Lyon, Lyon, France.; Centre de Pathologie EST, Groupement Hospitalier EST, Université de Lyon, Bron, France., Jouvet A; Centre de Pathologie EST, Groupement Hospitalier EST, Université de Lyon, Bron, France., French PJ; Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands., Kros JM; Department of Pathology, Erasmus University Medical Center, Rotterdam, Netherlands., Zitterbart K; Department of Pediatric Oncology, Masaryk University School of Medicine, Brno, Czech Republic., Bailey SD; Department of Surgery, Division of Thoracic and Upper Gastrointestinal Surgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Eberhart CG; Departments of Pathology, Ophthalmology and Oncology, John Hopkins University School of Medicine, Baltimore, MD, USA., Rao AAN; Division of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, USA., Giannini C; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Olson JM; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Garami M; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary., Hauser P; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary., Phillips JJ; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Ra YS; Department of Neurosurgery, University of Ulsan, Asan Medical Center, Seoul, South Korea., de Torres C; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Mora J; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Li KKW; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong., Ng HK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong., Poon WS; Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong., Pollack IF; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., López-Aguilar E; Division of Pediatric Hematology/Oncology, Hospital Pediatría Centro Médico Nacional century XXI, Mexico City, Mexico., Gillespie GY; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA., Van Meter TE; Pediatrics, Virginia Commonwealthy University, School of Medicine, Richmond, VA, USA., Shofuda T; Division of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital, Osaka, Japan., Vibhakar R; Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA., Thompson RC; Department of Neurological Surgery, Vanderbilt Medical Center, Nashville, TN, USA., Cooper MK; Department of Neurology, Vanderbilt Medical Center, Nashville, TN, USA., Rubin JB; Departments of Neuroscience, Washington University School of Medicine in St Louis, St Louis, MO, USA., Kumabe T; Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Japan., Jung S; Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Hwasun-gun, South Korea., Lach B; Department of Pathology and Molecular Medicine, Division of Anatomical Pathology, McMaster University, Hamilton, Ontario, Canada.; Department of Pathology and Laboratory Medicine, Hamilton General Hospital, Hamilton, Ontario, Canada., Iolascon A; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate, Naples, Italy., Ferrucci V; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate, Naples, Italy., de Antonellis P; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate, Naples, Italy., Zollo M; Dipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate, Naples, Italy., Cinalli G; Department of Pediatric Neurosurgery, Santobono-Pausilipon Children's Hospital, Naples, Italy., Robinson S; Division of Pediatric Neurosurgery, Case Western Reserve, Cleveland, OH, USA., Stearns DS; Department of Pediatrics-Hematology and Oncology, Case Western Reserve, Cleveland, OH, USA., Van Meir EG; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA., Porrati P; Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Finocchiaro G; Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Massimino M; Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Carlotti CG; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Faria CC; Division of Neurosurgery, Centro Hospitalar Lisboa Norte (CHULN), Hospital de Santa Maria, Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Roussel MF; Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN, USA., Boop F; Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN, USA., Chan JA; Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Aldinger KA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Razavi F; Assistance Publique Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France., Silvestri E; Surgical Pathology Unit, San Camillo Forlanini Hospital, Rome, Italy., McLendon RE; Department of Pathology, Duke University, Durham, NC, USA.; Department of Neurosurgery, Duke University, Durham, NC, USA., Thompson EM; Department of Neurosurgery, Duke University, Durham, NC, USA., Ansari M; Cansearch Research Platform for Pediatric Oncology and Hematology, Faculty of Medicine, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland.; Division of Pediatric Oncology and Hematology, Department of Women, Child and Adolescent, University Geneva Hospitals, Geneva, Switzerland., Garre ML; U.O. Neurochirurgia, Istituto Giannina Gaslini, Genova, Italy., Chico F; Department of Neurosurgery, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico., Eguía P; Department of Neurosurgery, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico., Pérezpeña M; Instituto Nacional De Pediatría de México, Mexico City, Mexico., Morrissy AS; Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada., Cavalli FMG; INSERM U900, Institut Curie, Paris, France.; PSL Research University, Institut Curie, Paris, France.; CBIO-Centre for Computational Biology, PSL Research University, MINES ParisTech, Paris, France., Wu X; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Daniels C; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Rich JN; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Jones SJM; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Moore RA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada., Marra MA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Huang X; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Reimand J; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Sorensen PH; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Weiss WA; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA., Pugh TJ; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Garzia L; Cancer Research Program, McGill University Health Centre Research Institute, Montreal, Quebec, Canada., Kleinman CL; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada., Stein LD; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Adaptive Oncology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Jabado N; Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada.; The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Malkin D; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada., Ayrault O; PSL Research University, Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Institut Curie, Orsay, France., Golden JA; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ellison DW; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA., Doble B; Department of Pediatrics and Child Health and Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada., Werbowetski-Ogilvie TE; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.; CancerCare Manitoba Research Institute, Winnipeg, Manitoba, Canada., Suzuki H; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Millen KJ; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Taylor MD; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.

Publikováno v: Nature [Nature] 2022 Dec; Vol. 612 (7940), pp. E12.

Unified rhombic lip origins of group 3 and group 4 medulloblastoma.

Autor: Smith KS; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA., Bihannic L; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA., Gudenas BL; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA., Haldipur P; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Tao R; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA., Gao Q; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA., Li Y; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA., Aldinger KA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Iskusnykh IY; Department of Anatomy and Neurobiology, University of Tennessee, Memphis, TN, USA., Chizhikov VV; Department of Anatomy and Neurobiology, University of Tennessee, Memphis, TN, USA., Scoggins M; Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA., Zhang S; Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA., Edwards A; Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA., Deng M; Department of Pediatrics, University of Washington, Seattle, WA, USA., Glass IA; Department of Pediatrics, University of Washington, Seattle, WA, USA., Overman LM; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK., Millman J; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Sjoboen AH; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Hadley J; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA., Golser J; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Mankad K; Department of Radiology, Great Ormond Street Hospital for Children, London, UK., Sheppard H; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA., Onar-Thomas A; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA., Gajjar A; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Robinson GW; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Hovestadt V; Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Orr BA; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA., Patay Z; Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA., Millen KJ; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Northcott PA; Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA. paul.northcott@stjude.org.

Publikováno v: Nature [Nature] 2022 Sep; Vol. 609 (7929), pp. 1012-1020. Date of Electronic Publication: 2022 Sep 21.