Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug

Autor: Mille B. L. Kryger, Almar Postma, Benjamin M. Wohl, Natasha Hedemann, Carlos Guerrero-Sanchez, Anton A. A. Smith, Alexander N. Zelikin

Publikováno v: Smith, A A A, Wohl, B M, Kryger, M B L, Hedemann, N, Guerrero-Sanchez, C, Postma, A & Zelikin, A N 2014, ' Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug ', Advanced Healthcare Materials, vol. 3, no. 9, pp. 1404-1407 . https://doi.org/10.1002/adhm.201300637

Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad-spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0682ffdc6440bf5840b965226ad093e8
https://doi.org/10.1002/adhm.201300637

Liposomal Templating, Association with Mammalian Cells, and Cytotoxicity of Poly(vinyl alcohol) Physical Hydrogel Nanoparticles

Autor: Almar Postma, Kenneth N. Goldie, Bettina E. B. Jensen, Alexander N. Zelikin, Siow-Feng Chong, Brigitte Städler, Sidsel Ø. Andreasen, Mille B. L. Kryger, Marie-Helene Alves

Publikováno v: Andreasen, S Ø, Chong, S F, Kryger, M, Jensen, B E B, Postma, A, Alves, M-H, Stadler, B M, Goldie, K & Zelikin, A N 2013, ' Liposomal Templating, Association with Mammalian Cells, and Cytotoxicity of Poly(vinyl alcohol) Physical Hydrogel Nanoparticles ', Particle & Particle Systems Characterization, vol. 30, no. 6, pp. 514-522 . https://doi.org/10.1002/ppsc.201200134

The assembly, cellular internalization, and cytotoxicity of nanoparticles based on physical hydrogels of poly(vinyl alcohol) (PVA) are reported. PVA nanoparticles are assembled using a liposomal templating technique followed by removal of the lipids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f742464fada64d1d4cace67b5450546b
https://doi.org/10.1002/ppsc.201200134

Tools of gene transfer applied to the intracellular delivery of non-nucleic acid polyanionic drugs

Autor: Alexander N. Zelikin, Søren Pedersen, Mille B. L. Kryger, Benjamin M. Wohl

Publikováno v: Kryger, M B L, Pedersen, S L, Wohl, B M & Zelikin, A N 2016, ' Tools of gene transfer applied to the intracellular delivery of non-nucleic acid polyanionic drugs ', Chemical Communications, vol. 52, no. 5, pp. 889-891 . https://doi.org/10.1039/c5cc08011h

We report the first successful implementation of transfection agents to facilitate the delivery of non-nucleic acid based anti-inflammatory and anti-viral drugs. In doing so, we illustrate a new paradigm in the intracellular delivery of polyanionic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ee017d8a4bca71e1784de2ef1c4120
https://pubmed.ncbi.nlm.nih.gov/26576493

Narrow therapeutic window of ribavirin as an inhibitor of nitric oxide synthesis is broadened by macromolecular prodrugs

Autor: Mille B. L. Kryger, Benjamin M. Wohl, Anton A. A. Smith, Alexander N. Zelikin

Publikováno v: Wohl, B M, Smith, A A A, Kryger, M B L & Zelikin, A N 2013, ' Narrow Therapeutic Window of Ribavirin as an Inhibitor of Nitric Oxide Synthesis is Broadened by Macromolecular Prodrugs ', Biomacromolecules, vol. 14, no. 11, pp. 3916-26 . https://doi.org/10.1021/bm401048s

Ribavirin (RBV), a broad-spectrum antiviral agent, is a standard medication against hepatitis C virus (HCV). However, despite the decades of clinical success, the mechanism of action of this drug against HCV remains a subject of debate. Furthermore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a380d15eb08431ab6e9816ff76ff516e
https://pubmed.ncbi.nlm.nih.gov/24156371

Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug

Autor: Benjamin M. Wohl, Anton A. A. Smith, Alexander N. Zelikin, Mille B. L. Kryger

Publikováno v: Kryger, M B L, Wohl, B M, Smith, A A A & Zelikin, A N 2013, ' Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug ', Chemical Communications, vol. 49, no. 26, pp. 2643-2645 . https://doi.org/10.1039/c3cc00315a

Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT co-polymerization with acrylic acid afforded a formulation of a broad spectrum antiviral drug which avoids accumulation in erythrocytes, the origin of the main side effect of ribavir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7fe7cf2ccd93a965ec51d6a072e60a
https://pure.au.dk/portal/da/publications/macromolecular-prodrugs-of-ribavirin-combat-side-effects-and-toxicity-with-no-loss-of-activity-of-the-drug(a1c9346e-1576-4cb5-bc26-8cd9acea4e2a).html