A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease

Autor: Nathan, Pradeep J, Millais, S Babli, Godwood, Alex, Dewit, Odile, Cross, David M, Liptrot, Janet, Ruparelia, Bharat, Jones, Stephen Paul, Bakker, Geor, Maruff, Paul T, Light, Gregory A, Brown, Alastair JH, Weir, Malcolm Peter, Congreve, Miles, Tasker, Tim

Funder: Allergan Incorporated (now AbbVie)
INTRODUCTION: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer's disease (AD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e38653d2f765360f2d6de5cd6a20a7b
https://www.repository.cam.ac.uk/handle/1810/334362

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.

Autor: Nathan PJ; Heptares Therapeutics Ltd Cambridge UK.; Department of Psychiatry University of Cambridge Cambridge UK., Millais SB; Heptares Therapeutics Ltd Cambridge UK., Godwood A; Heptares Therapeutics Ltd Cambridge UK., Dewit O; Heptares Therapeutics Ltd Cambridge UK., Cross DM; Cross Pharma Consulting Limited Cambridge UK., Liptrot J; Heptares Therapeutics Ltd Cambridge UK., Ruparelia B; Heptares Therapeutics Ltd Cambridge UK., Jones SP; tranScrip Partners LLP Wokingham UK., Bakker G; Heptares Therapeutics Ltd Cambridge UK., Maruff PT; Cogstate Ltd New Haven Connecticut USA., Light GA; Department of Psychiatry University of San Diego San Diego California USA., Brown AJH; Heptares Therapeutics Ltd Cambridge UK., Weir MP; Heptares Therapeutics Ltd Cambridge UK., Congreve M; Heptares Therapeutics Ltd Cambridge UK., Tasker T; Heptares Therapeutics Ltd Cambridge UK.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2022 Feb 23; Vol. 8 (1), pp. e12273. Date of Electronic Publication: 2022 Feb 23 (Print Publication: 2022).