A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation.

Autor: Sanna Vuoristo, Sanna Toivonen, Jere Weltner, Milla Mikkola, Jarkko Ustinov, Ras Trokovic, Jaan Palgi, Riikka Lund, Timo Tuuri, Timo Otonkoski

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76205 (2013)

Correct interactions with extracellular matrix are essential to human pluripotent stem cells (hPSC) to maintain their pluripotent self-renewal capacity during in vitro culture. hPSCs secrete laminin 511/521, one of the most important functional basem

Externí odkaz: https://doaj.org/article/f1b1fe9ec2564279b3d7b8defd43e6d0

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

Autor: Nissim Benvenisty, Minal Patel, Glyn Stacey, Lesley Young, Sanna Vuoristo, Barak Blum, Robert Passier, Steve Oh, Rebecca S. Hamilton, Miodrag Stojkovic, Barbara B. Knowles, Benjamin Reubinoff, Kehkooi Kee, Barbara S. Mallon, Andras Nagy, Michal Amit, Janet Rossant, Paul J. Gokhale, Franck Lebrin, Henrike Siemen, Simon Bevan, Weidong Zhang, Milla Mikkola, Stephen L. Minger, Norio Nakatsuji, Peter W. Andrews, Eric S Sherrer, Paul Bello, Tikva Turetsky, Lorraine S. Berry, Behrouz Aflatoonian, Christine L. Mummery, Masha Mileikovsky, Yoav Mayshar, Angela Ford, Harry Moore, Mark Jones, Joseph Itskovitz-Eldor, Jackie Johnson, Lars Ährlund-Richter, Roland A. Fleck, Oluseun Adewumi, Jamie P. Jackson, Alex Hampl, Andre Bh Choo, Petr Dvorak, Timo Otonkoski, Daisy Manning, Henrik Semb, Marta P. Imreh, Justin Brooking, Marina Gertsenstein, Dorien Ward, Jin P. Szatkiewicz, Timo Tuuri, Thomas C Schulz, Marian S Piekarczyk, Kevin G. Chen, Karin Astrid Maria Gertow, Renee A. Reijo Pera, Thomas A Weaver, Gemma Beighton, Kye-Yoon Park, Majlinda Lako, Ronald D.G. McKay, Katarina Emanuelsson, Cia Olsson, Carmel M. O’Brien, Johan Hyllner, Hema Patel, Outi Hovatta, Allan J. Robins, Hirofumi Suemori, Peter J. Rugg-Gunn, Martin F. Pera, Marie Corbel, Gary A. Churchill, Ivan Damjanov, John S Draper, Benjamin L. King, Lyn Healy, Steineke van den Brink, Roger A. Pedersen, Anna E. Michalska, Kristina Vintersten

Publikováno v: Nature Biotechnology. 25:803-816

The International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867a067cc25cab7204dd3712d4e89593
https://doi.org/10.1038/nbt1318

Gene Expression Signatures of Seven Individual Human Embryonic Stem Cell Lines

Autor: Timo Tuuri, Timo Otonkoski, Outi Hovatta, Milla Mikkola, Riitta Lahesmaa, Cia Olsson, Anne-Marie Strömberg, Heli Skottman, Karolina Lundin

Publikováno v: STEM CELLS. 23:1343-1356

Identification of molecular components that define a pluripotent human embryonic stem cell (hESC) provides the basis for understanding the molecular mechanisms regulating the maintenance of pluripotency and induction of differentiation. We compared t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6491f1a724c2b27e2028767193b8135
https://doi.org/10.1634/stemcells.2004-0341

Follicles Are Found in the Ovaries of Adolescent Girls with Turner’s Syndrome

Autor: Julius Hreinsson, Milla Mikkola, Margareta Fridström, Carsten Rasmussen, Timo Tuuri, Marjut Otala, Leo Dunkel, Birgit Borgström, Niklas Simberg, Monalill Lundqvist, Outi Hovatta

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 87:3618-3623

Infertility caused by ovarian failure is a characteristic feature in Turner’s syndrome. Spontaneous pregnancies are seen in 2–5% of these women, and up to 30% have at least some pubertal development, indicating the presence of follicles in their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bfed85af1b20a805861ca042b0f84a
https://doi.org/10.1210/jcem.87.8.8753

Copy number variation and selection during reprogramming to pluripotency

Autor: Milla Mikkola, Riitta Lahesmaa, Reija Autio, Oliver Brüstle, Siemon Ng, Reagan W. Ching, Michel Sourour, Samer M.I. Hussein, David P. Bazett-Jones, Elisa Närvä, Sanna Vuoristo, Cia Olsson, Timo Otonkoski, Kari Alitalo, Karolina Lundin, Riikka H. Hämäläinen, Andras Nagy, Michael Peitz, Nizar N. Batada, Ras Trokovic

Publikováno v: Nature. 471(7336)

The mechanisms underlying the low efficiency of reprogramming somatic cells into induced pluripotent stem (iPS) cells are poorly understood. There is a clear need to study whether the reprogramming process itself compromises genomic integrity and, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbd8746e11362a7131f53b48c703973
https://pubmed.ncbi.nlm.nih.gov/21548395