Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Milind A Phadnis"'
Publikováno v:
Contemporary Clinical Trials Communications, Vol 41, Iss , Pp 101344- (2024)
Background: Time-to-event (TTE) endpoints are evaluated as the primary endpoint in single-arm clinical trials; however, limited options are available in statistical software for sample size calculation. In single-arm trials with TTE endpoints, the no
Externí odkaz:
https://doaj.org/article/258b011ea60f4bb18413a71459d30d14
Publikováno v:
Contemporary Clinical Trials Communications, Vol 40, Iss , Pp 101315- (2024)
A group sequential design allows investigators to sequentially monitor efficacy and safety as part of interim testing in phase III trials. Literature is well developed in the case of continuous and binary outcomes, however, in case of trials with a t
Externí odkaz:
https://doaj.org/article/d91cb5c32a4c4da99cfd6d3e094e0b2e
Autor:
Elise Hoover, Vanessa Holliday, Nicole Merullo, Dorothee Oberdhan, Ronald D. Perrone, Chris Rusconi, Meyeon Park, Milind A. Phadnis, Nadeesha Thewarapperuma, Neera K. Dahl
Publikováno v:
Kidney Medicine, Vol 6, Iss 5, Pp 100813- (2024)
Rationale & Objective: Autosomal dominant polycystic kidney disease (ADPKD) affects health-related quality of life (HRQoL) including pain, discomfort, fatigue, emotional distress, and impaired mobility. Stakeholders prioritized kidney cyst-related pa
Externí odkaz:
https://doaj.org/article/f4ea332d6b3a4a40bb39c6bd2ec097f8
Autor:
Weijing Sun, Nirmal Veeramachaneni, Raed Al‐Rajabi, Rashna Madan, Anup Kasi, Mazin Al‐Kasspooles, Joaquina Baranda, Anwaar Saeed, Milind A. Phadnis, Andrew K. Godwin, Mojtaba Olyaee, Natalie Streeter, Alykhan Nagji, Junqiang Dai, Stephen Williamson
Publikováno v:
Cancer Medicine, Vol 12, Iss 15, Pp 16098-16107 (2023)
Abstract Background Perioperative chemotherapy/chemoradiation is standard in esophageal/gastric/gastroesophageal junction (GEJ) adenocarcinoma, immune checkpoint inhibitors (ICI) effect in setting of metastatic and postoperatively. This study is to a
Externí odkaz:
https://doaj.org/article/613b6c3bdc634b1eace9ff580f7c8506
Autor:
Rafia S. Rasu, Rana Zalmai, Aliza R. Karpes Matusevich, Suzanne L. Hunt, Milind A. Phadnis, Nahid Rianon
Publikováno v:
BMC Geriatrics, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background About 50% of all hospitalized fragility fracture cases in older Americans are hip fractures. Approximately 3/4 of fracture-related costs in the USA are attributable to hip fractures, and these are mostly covered by Medicare. Hip f
Externí odkaz:
https://doaj.org/article/e7996a3fe3a646e89b078462b3693631
Autor:
Mohammed M. Alshehri, Shaima A. Alothman, Aqeel M. Alenazi, Jason L. Rucker, Milind A. Phadnis, John M. Miles, Catherine F. Siengsukon, Patricia M. Kluding
Publikováno v:
BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Previous studies have shown the negative impact of sleep disturbances, specifically insomnia symptoms, on glucose metabolism for people with type 2 diabetes (T2D). People with insomnia symptoms are at risk of poor glycemic control
Externí odkaz:
https://doaj.org/article/a491c8e59466402cbd4cf49f8681fbf8
Autor:
Dinesh Pal Mudaranthakam, Milind A. Phadnis, Ron Krebill, Lauren Clark, Jo A. Wick, Jeffrey Thompson, John Keighley, Byron J. Gajewski, Devin C. Koestler, Matthew S. Mayo
Publikováno v:
Contemporary Clinical Trials Communications, Vol 18, Iss , Pp 100579- (2020)
1. Abstract: Early phase clinical trials are the first step in testing new medications and therapeutics developed by clinical and biomedical investigators. These trials aim to find a safe dose of a newly targeted drug (phase I) or find out more about
Externí odkaz:
https://doaj.org/article/3cc8b5b24ad24077bdcf70c6f17246dd
Publikováno v:
Contemporary Clinical Trials Communications, Vol 17, Iss , Pp - (2020)
Background: Recent developments in literature on sample size calculations for time-to-event outcomes involve assumption of Weibull distributed times. These methods require a point estimate of the Weibull shape parameter obtained from historical studi
Externí odkaz:
https://doaj.org/article/11ffb24fa9b4402a8be68fc5046b693a
Autor:
Milind A. Phadnis
Publikováno v:
Contemporary Clinical Trials Communications, Vol 15, Iss , Pp - (2019)
Background: Sample size calculations are critical to the planning of a clinical trial. For single-arm trials with time-to-event endpoint, standard software provides only limited options. The most popular option is the log-rank test. A second option a
Externí odkaz:
https://doaj.org/article/91fb2acef96f4f5ea24b6b15e36ac2d3
Autor:
Theresa I. Shireman, Jonathan D. Mahnken, Milind A. Phadnis, Edward F. Ellerbeck, James B. Wetmore
Publikováno v:
Kidney & Blood Pressure Research, Vol 41, Iss 6, Pp 873-885 (2016)
Background/Aims: Whether angiotensin converting enzyme inhibitors (ACE) and angiotensin receptor blockers (ARB) are differentially associated with reductions in cardiovascular events and mortality in patients receiving maintenance dialysis is uncerta
Externí odkaz:
https://doaj.org/article/c5fe217ffe1a4f2d84b30433a0d01627