Formation of foamy macrophages by tuberculous pleural effusions is triggered by the interleukin-10/Signal transducer and activator of transcription 3 axis through ACAT upregulation

Autor: Melanie Genoula, José Luis Marín Franco, Maeva Dupont, Denise Kviatcovsky, Ayelén Milillo, Pablo Schierloh, Eduardo Jose Moraña, Susana Poggi, Domingo Palmero, Dulce Mata-Espinosa, Erika González-Domínguez, Juan Carlos León Contreras, Paula Barrionuevo, Bárbara Rearte, Marlina Olyissa Córdoba Moreno, Adriana Fontanals, Agostina Crotta Asis, Gabriela Gago, Céline Cougoule, Olivier Neyrolles, Isabelle Maridonneau-Parini, Carmen Sánchez-Torres, Rogelio Hernández-Pando, Christel Vérollet, Geanncarlo Lugo-Villarino, María del Carmen Sasiain, Luciana Balboa

Publikováno v: RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2018, 9, ⟨10.3389/fimmu.2018.00459⟩
Frontiers in Immunology, Vol 9 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The ability of Mycobacterium tuberculosis (Mtb) to persist in its human host relies on numerous immune evasion strategies, such as the deregulation of the lipid metabolism leading to the formation of foamy macrophages (FM). Yet, the specific host fac

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