Cílená mutageneze ve studiu lidských cytochromů P450 rodiny 1 a jejich interakčních partnerů

Autor: Milichovský, Jan

Cytochromes P450 represent a large group of proteins metabolizing variety of substrates. Many of them are responsible for metabolism of xenobiotics including drugs and chemical carcinogens. Heme-protein cytochrome b5 is a single-electron donor cooper

Externí odkaz: http://www.nusl.cz/ntk/nusl-352109

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

Autor: Milichovský, Jan¹ jan.milichovsky@natur.cuni.cz, Bárta, František¹ frantisek.barta@natur.cuni.cz, Schmeiser, Heinz H.² h.schmeiser@dkfz-heidelberg.de, Arlt, Volker M.³ volker.arlt@kcl.ac.uk, Frei, Eva¹ evafrei@t-online.de, Stiborová, Marie¹ stiborov@natur.cuni.cz, Martínek, Václav¹ vacmar@natur.cuni.cz

Publikováno v: International Journal of Molecular Sciences. 2016, Vol. 17 Issue 2, p213. 16p. 3 Color Photographs, 1 Diagram, 3 Charts, 2 Graphs.

Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine

Autor: Mrízová, Iveta, Moserová, Michaela, Milichovský, Jan, Šulc, Miroslav, Kizek, René, Kubáčková, Kateřina, Arlt, Volker M., Stiborová, Marie

Publikováno v: Mrízová, I, Moserová, M, Milichovský, J, Šulc, M, Kizek, R, Kubáčková, K, Arlt, V M & Stiborová, M 2016, ' Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine ', Monatshefte für Chemie-Chemical Monthly, vol. 147, no. 5, pp. 881–888 . https://doi.org/10.1007/s00706-016-1738-2

Cytochrome P450 (CYP) 2S1 is “orphan” CYP that is overexpressed in several epithelial tissues and many human tumors. The pure enzyme is required for better understanding of its biological functions. Therefore, human CYP2S1 was considered to be pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d23e5923f453b19f82fe7a73d467e1ab
https://kclpure.kcl.ac.uk/en/publications/4b0f23ea-a26e-4baa-9582-0b41bec268e7

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Induced Expression ofCytochrome P450 1A and NAD(P)H:QuinoneOxidoreductase Determined at mRNA, Protein, and Enzyme Activity Levelsin Rats Exposed to the Carcinogenic Azo Dye 1-Phenylazo-2-naphthol(Sudan I).

Autor: Stiborová, Marie, Dračínská, Helena, Martínek, Václav, Svášková, Dagmar, Hodek, Petr, Milichovský, Jan, Hejduková, Žaneta, Brotánek, Jaroslav, Schmeiser, Heinz H., Frei, Eva

Publikováno v: Chemical Research in Toxicology; Feb2013, Vol. 26 Issue 2, p290-299, 10p