TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.

Autor: Vierra NC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Dickerson MT; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Jordan KL; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Katdare KA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Altman MK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Milian SC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: david.a.jacobson@vanderbilt.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2018 Mar; Vol. 9, pp. 84-97. Date of Electronic Publication: 2018 Jan 31.

TALK-1 channels control β cell endoplasmic reticulum Ca ²⁺ homeostasis.

Autor: Vierra NC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Milian SC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Dickerson MT; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Jordan KL; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Gilon P; Pôle d'endocrinologie, diabète et nutrition, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels 1200, Belgium., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. david.a.jacobson@vanderbilt.edu.

Publikováno v: Science signaling [Sci Signal] 2017 Sep 19; Vol. 10 (497). Date of Electronic Publication: 2017 Sep 19.

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults.

Autor: Nakhe, Arya Y., Dadi, Prasanna K., Jinsun Kim, Dickerson, Matthew T., Behera, Soma, Dobson, Jordyn R., Shrestha, Shristi, Cartailler, Jean-Philippe, Sampson, Leesa, Magnuson, Mark A., Jacobson, David A.

Publikováno v: eLife; 5/3/2024, p1-25, 25p

The effects of antihypertensive drugs on glucose metabolism.

Autor: Li Z; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.; The First Clinical Medical College, Shanxi Medical University, Taiyuan, China., Wei H; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.; The First Clinical Medical College, Shanxi Medical University, Taiyuan, China., Li R; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.; The First Clinical Medical College, Shanxi Medical University, Taiyuan, China., Wu B; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.; The First Clinical Medical College, Shanxi Medical University, Taiyuan, China., Xu M; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.; The First Clinical Medical College, Shanxi Medical University, Taiyuan, China., Yang X; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.; The First Clinical Medical College, Shanxi Medical University, Taiyuan, China., Zhang Y; Department of Pharmacology, Shanxi Medical University, Taiyuan, China.; Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, China., Liu Y; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.; Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, China.; Clinical Research Center For Metabolic Diseases Of Shanxi Medical University, Taiyuan, China.

Publikováno v: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Nov; Vol. 26 (11), pp. 4820-4829. Date of Electronic Publication: 2024 Aug 14.

KCNH6 is essential for insulin secretion by regulating intracellular ER Ca ²⁺ store.

Autor: Xiong FR; Department of Endocrinology, Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Lu J; Department of Endocrinology, Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Zhu JJ; Department of Endocrinology, Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Zhao RX; Department of Endocrinology, Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Zhang YC; Department of Endocrinology, Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Yang JK; Department of Endocrinology, Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Feb 29; Vol. 38 (4), pp. e23490.