Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mili Pathak"'
Publikováno v:
Bioinformatics Tools for Pharmaceutical Drug Product Development. :401-416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8a96f06db4d9188d3654644e0d9e9b
https://doi.org/10.1002/9781119865728.ch17
https://doi.org/10.1002/9781119865728.ch17
Publikováno v:
Biotechnology Progress. 38
Process understanding and characterization forms the foundation, ensuring consistent and robust biologics manufacturing process. Using appropriate modeling tools and machine learning approaches, the process data can be monitored in real time to avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add36222bf3396ba5190d497d927d5e7
https://doi.org/10.1002/btpr.3252
https://doi.org/10.1002/btpr.3252
Publikováno v:
Journal of Chromatography A. 1570:56-66
Protein A chromatography is quite commonly used for capture of monoclonal antibodies from the clarified cell culture broths. Protein A resins are expensive and economic feasibility demands that the resin be reused for 50-300 cycles. Resin reuse is, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7f2140adfa5675d7f56feadcff9f03
https://doi.org/10.1016/j.chroma.2018.07.060
https://doi.org/10.1016/j.chroma.2018.07.060
Publikováno v:
Biotechnology Progress. 34:412-419
Adsorbent lifetime during protein A chromatography is not readily predicted or understood, representing a key challenge to be addressed for biopharmaceutical manufacturers. This article focuses on the impact of feed composition on the performance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370cb0b948e90daa78cc6fdd775d7d29
https://doi.org/10.1002/btpr.2608
https://doi.org/10.1002/btpr.2608
Autor:
Aswathy M. Nair, Mili Pathak, T.F. Johnson, Anurag S. Rathore, Daniel G. Bracewell, Katherine Lintern, Soumyo Mukherji
Publikováno v:
Electrophoresis5 References. 40(23-24)
Protein A resins are often reused for multiple cycles to improve process economy during mAb purification. Significant reduction in binding capacity and product recovery are typically observed due to the presence of unwanted materials (foulants) depos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d11c75e0d18b68fe05e009f11b68e9
https://pubmed.ncbi.nlm.nih.gov/31562772
https://pubmed.ncbi.nlm.nih.gov/31562772
Publikováno v:
Engineering in Life Sciences. 17:448-457
Rapid quantitation of product titer is a critical input for control of any bioprocess. This measurement, however, is marred by the myriad components that are present in the fermentation broth, often requiring extensive sample pretreatment before anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49d7dc151c9bc67d90e3d2c9a05d6d89
https://doi.org/10.1002/elsc.201600155
https://doi.org/10.1002/elsc.201600155
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 126:124-131
Protein based therapeutics dominate most pharmaceutical pipelines today. For a therapeutic product to be effective, it is important that it is in its native form as slight modifications have been known to result in significantly different performance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c1745efafedeea9bcd67cc6f1048aa
https://doi.org/10.1016/j.jpba.2016.05.001
https://doi.org/10.1016/j.jpba.2016.05.001
Publikováno v:
Chemical Engineering Science. 140:153-160
A novel coiled flow inverter (CFI) based plug flow reactor has been developed for continuous refolding of granulocyte colony stimulating factor (GCSF), a biotech therapeutic product. Solubilized inclusion bodies containing the denatured and reduced f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b11bc19965f5d21f720e154079641e
https://doi.org/10.1016/j.ces.2015.10.009
https://doi.org/10.1016/j.ces.2015.10.009
Publikováno v:
Biotechnology Progress. 32:355-362
Biotherapeutics have become the focus of the pharmaceutical industry due to their proven effectiveness in managing complex diseases. Downstream processes of these molecules consist of several orthogonal, high resolution unit operations designed so as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc152610a131fa18a39dc8226784b84c
https://doi.org/10.1002/btpr.2209
https://doi.org/10.1002/btpr.2209
Autor:
Mili Pathak, Erik K. Read, Kurt Brorson, Anurag S. Rathore, Mansoor A. Khan, Sumit Kumar Singh, Cyrus Agarabi
Publikováno v:
Biotechnology Progress. 31:1586-1599
Fermentanomics is an emerging field of research and involves understanding the underlying controlled process variables and their effect on process yield and product quality. Although major advancements have occurred in process analytics over the past
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c46008f40d3e2bc7abc21c35226820
https://doi.org/10.1002/btpr.2155
https://doi.org/10.1002/btpr.2155