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Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs.

Autor: Seo JW; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Ajenjo J; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Wu B; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Robinson E; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Raie MN; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Wang J; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Tumbale SK; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Buccino P; Stanford Cyclotron & Radiochemistry Facility (CRF), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Anders DA; Stanford Cyclotron & Radiochemistry Facility (CRF), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Shen B; Stanford Cyclotron & Radiochemistry Facility (CRF), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Habte FG; Stanford Center for Innovation in In vivo Imaging (SCi3), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Beinat C; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., James ML; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Reyes ST; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Ravindra Kumar S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Miles TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Lee JT; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA., Gradinaru V; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Ferrara KW; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: kwferrar@stanford.edu.

Publikováno v: Biomaterials [Biomaterials] 2022 Sep; Vol. 288, pp. 121701. Date of Electronic Publication: 2022 Aug 06.

Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.

Autor: Challis RC; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Ravindra Kumar S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Chen X; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Goertsen D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Coughlin GM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Hori AM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Chuapoco MR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Otis TS; Sainsbury Wellcome Centre, University College London, London, United Kingdom., Miles TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu., Gradinaru V; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; email: viviana@caltech.edu.

Publikováno v: Annual review of neuroscience [Annu Rev Neurosci] 2022 Jul 08; Vol. 45, pp. 447-469. Date of Electronic Publication: 2022 Apr 19.

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.

Autor: Miles TF; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, United States., Spiess K; Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Science, University of Copenhagen, Denmark, Europe., Jude KM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, United States., Tsutsumi N; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, United States., Burg JS; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, United States., Ingram JR; Department of Cancer Immunology and Virology, Dana Farber Cancer Institute, Boston, United States., Waghray D; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, United States., Hjorto GM; Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Science, University of Copenhagen, Denmark, Europe., Larsen O; Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Science, University of Copenhagen, Denmark, Europe., Ploegh HL; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, United States., Rosenkilde MM; Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Science, University of Copenhagen, Denmark, Europe., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, United States.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States.

Publikováno v: ELife [Elife] 2018 Jun 08; Vol. 7. Date of Electronic Publication: 2018 Jun 08.

The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.

Autor: Miles TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Dougherty DA, Lester HA

Publikováno v: Biophysical journal [Biophys J] 2013 Aug 20; Vol. 105 (4), pp. 887-98.