Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Miles S, Congreve"'
Autor:
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Externí odkaz:
https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b
Autor:
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/e8d149c342564fbcb1a1d42b3d13ea6d
Autor:
Stacey M. Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D. Cansfield, Julie E. Cansfield, Miles S. Congreve, Gabriella Cseke, Francesca Deflorian, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Renata Rupcic, Gordon Saxty, Stephen P. Watson
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1776-1782
The diastereomeric macrocyclic calcitonin generelated peptide (CGRP) antagonists HTL0029881 (3) and HTL0029882 (4), in which the stereochemistry of a spiro center is reversed, surprisingly demonstrate comparable potency. X-ray crystallographic charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6056f84865bf327ec61e26bf41ed7b3
https://doi.org/10.1021/acsmedchemlett.2c00400
https://doi.org/10.1021/acsmedchemlett.2c00400
Autor:
Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin
Publikováno v:
Trends Pharmacol Sci
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279
https://pubmed.ncbi.nlm.nih.gov/35101279
Autor:
Alastair J. H. Brown, Sophie J. Bradley, Giles A. Brown, Kirstie A. Bennett, Jason Brown, Julie E. Cansfield, David M. Cross, João M. Dias, James C. Errey, Edward Hurrell, Jan Liptrot, Colin Molloy, Pradeep J. Nathan, Krzysztof Okrasa, Greg Osbourne, Jayesh C. Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M. Broad, Anushka V. Goonawardena, Stephen R. Morairty, Michael Browning, Francesca Perini, Gerard R. Dawson, John F. W. Deakin, Robert T. Smith, Patrick M. Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G. Tehan, Barry Teobald, Arthur Christopoulos, Christopher J. Langmead, Ali Jazayeri, Robert M. Cooke, Fiona H. Marshall, Prakash Rucktooa, Miles S. Congreve, Malcolm Weir, Andrew Tobin
Publikováno v:
SSRN Electronic Journal.
Current therapies for improving memory in Alzheimer’s disease are focused on correcting for defective cholinergic transmission by increasing acetylcholine levels through inhibition of acetylcholinesterase enzymes. These treatments are however assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9223ad5ca22fdc8ece3f25838d310314
https://doi.org/10.2139/ssrn.3641933
https://doi.org/10.2139/ssrn.3641933
Publikováno v:
Journal of Combinatorial Chemistry. 6:375-384
The development, evaluation, and application of a novel safety-catch linker for solid-phase synthesis based on an N-tosylindole is reported. The development of this linker using analytical constructs to aid analysis is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852751acd9a57149607a31478d70e4c9
https://doi.org/10.1021/cc0499791
https://doi.org/10.1021/cc0499791
Autor:
Miles S Congreve, Craig Jamieson
Publikováno v:
Drug Discovery Today. 7:139-142
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52ecaae425857674b1f50141183777f
https://doi.org/10.1016/s1359-6446(02)00009-0
https://doi.org/10.1016/s1359-6446(02)00009-0
Autor:
Geoff M. Williams, Robin A. E. Carr, Miles S. Congreve, Corinne Kay, Stephen C. McKeown, Peter J. Murray, Jan J. Scicinski, Stephen P. Watson
Publikováno v:
Angewandte Chemie. 112:3431-3434
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f85ee0596510490296da168f019e7d01
https://doi.org/10.1002/1521-3757(20000915)112:18<3431::aid-ange3431>3.0.co
https://doi.org/10.1002/1521-3757(20000915)112:18<3431::aid-ange3431>3.0.co
Autor:
Jan J. Scicinski, Geoff M. Williams, Robin A. E. Carr, Miles S. Congreve, Corinne Kay, Peter John Murray, Stephen C. McKeown, Stephen P. Watson
Publikováno v:
Angewandte Chemie. 39:3293-3296
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ef12b1e59a2f2866c9c3cf2ec8f4ce6
https://doi.org/10.1002/1521-3773(20000915)39:18<3293::aid-anie3293>3.0.co
https://doi.org/10.1002/1521-3773(20000915)39:18<3293::aid-anie3293>3.0.co
Autor:
Andrew N. Payne, Andrew B. Holmes, Craig L. Francis, Neil Roy Curtis, Jonathan W. Burton, Miles S. Congreve, S. Y. Frankie Mak
Publikováno v:
Synthesis. :3199-3201
A synthesis of the halogenated medium-ring ether natural product (+)-obtusenyne is reported utilizing a Claisen rearrangement and an intramolecular hydrosilation as key steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173b686cb74f8e79a76d22c10953f27c
https://doi.org/10.1055/s-2005-918470
https://doi.org/10.1055/s-2005-918470