2-OR: Exosomes from Adipose Tissue Macrophages Can Mediate Insulin-Sensitizing Effects of Rosiglitazone

Autor: THERESA V. ROHM, FELIPE C.G. REIS, ROI ISAAC, MILES PASZEK, GAUTAM BANDYOPADHYAY, JERROLD M. OLEFSKY

Publikováno v: Diabetes. 71

Background: The beneficial metabolic effects of the PPARγ agonist rosiglitazone (Rosi) are associated with anti-inflammatory changes in adipose tissue macrophages (ATMs) . One study aim was to characterize the in vivo Rosi-induced phenotypic switch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef57345d697d6464948efbfa31f8f348
https://doi.org/10.2337/db22-2-or

NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate inhUGT1Mice

Autor: Robert H. Tukey, Miles Paszek

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals, vol 48, iss 1
Drug Metab Dispos

Environmental toxicants such as heavy metals from contaminated water or soil and isothiocyanates (ITC) from dietary sources act as pro-oxidants by directly generating reactive oxygen species (ROS) or through depleting cellular antioxidants such as gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cda94d7bc4afc27207333f31c5089f4
https://doi.org/10.1124/dmd.119.089508

NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult

Autor: Christopher Benner, Elvira Mennillo, Miles Paszek, Xiaojing Yang, Johan Auwerx, Shujuan Chen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 133-147 (2020)
Cellular and molecular gastroenterology and hepatology, vol 10, iss 1

Background & Aims Colonic stem cells are essential for producing the mucosal lining, which in turn protects stem cells from insult by luminal factors. Discovery of genetic and biochemical events that control stem cell proliferation and differentiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539bc3a01c5fc05129cd03aed3fa1d4d
https://pubmed.ncbi.nlm.nih.gov/32044398

Correction for Chen et al., Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

Autor: Ronald M. Evans, Eva Rettenmeier, Miao Liu, Wenqi Lu, Miles Paszek, Ruth T. Yu, Shujuan Chen, Robert H. Tukey, Mei-Fei Yueh, Michael Karin, Kepeng Wang, Johan Auwerx

Publikováno v: Proceedings of the National Academy of Sciences. 114

Reference EPFL-ARTICLE-229716doi:10.1073/pnas.1705671114View record in Web of Science Record created on 2017-07-10, modified on 2017-07-10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d15af25a45eeba481cbb9ac16361d0a
https://doi.org/10.1073/pnas.1705671114

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

Autor: Johan Auwerx, Mei-Fei Yueh, Ruth T. Yu, Shujuan Chen, Ronald M. Evans, Michael Karin, Wenqi Lu, Eva Rettenmeier, Robert H. Tukey, Miles Paszek, Miao Liu, Kepeng Wang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 8

Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin. Although there is a good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbae103d3f1f33bf8101f0be3e6a1f6e
https://pubmed.ncbi.nlm.nih.gov/28484028