Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Miles P. Hacker"'
Publikováno v:
Annals of the New York Academy of Sciences. 805:516-520
Publikováno v:
Biochemical Pharmacology. 63:1143-1147
In an attempt to overcome the cardiotoxicity and cross-resistance problems caused by the anticancer drugs anthracyclines and anthracenediones during chemotherapy, we have developed a series of aza-anthracenedione compounds by modifying the chromophor
Publikováno v:
Biochemical Pharmacology. 62:1337-1343
The anthrapyrazoles have entered clinical trials and show significant activity against breast cancer. However, these drugs are cardiotoxic and ineffective in multidrug-resistant (MDR) tumor cells. We have reported previously on the synthesis and anti
Autor:
M Wallace, Miles P. Hacker, Lori Leach, A Kallen, D. Freilich, James C. Hebert, D Nelson, J Frincke, C Ahlem, S Ferris
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 63:280-283
Dehydroepiandrosterone (DHEA) and its analogue, 16-bromoepiandrosterone (-epi-Br), may have activity against viral and parasitic infections, including human immunodeficiency virus (HIV) and Cryptosporidium parvum. Therefore, we evaluated its antimala
Autor:
Lori Leach, Sonja Ferris, Beverly Barry, Daniel Freilich, Miles P. Hacker, James C. Hebert, Richard F. Branda
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 60:322-328
Severe anemia is a major cause of death in falciparum malaria. Blood transfusion increases survival in humans and in animal models of this disease. Because of logistic constraints and viral contamination of the blood supply, transfusions are frequent
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 32, Iss 7, Pp 827-833 (1999)
Brazilian Journal of Medical and Biological Research v.32 n.7 1999
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 32, Issue: 7, Pages: 827-833, Published: JUL 1999
Brazilian Journal of Medical and Biological Research v.32 n.7 1999
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 32, Issue: 7, Pages: 827-833, Published: JUL 1999
Resistance to anticancer drugs is a major cause of failure of many therapeutic protocols. A variety of mechanisms have been proposed to explain this phenomenon. The exact mechanism depends upon the drug of interest as well as the tumor type treated.
Publikováno v:
Bulletin of the Chemical Society of Ethiopia, Vol 2, Iss 2, Pp 69-72 (1988)
Bull.Chem.Soc.Ethiop.,2(2), 69-72 (1988).
Externí odkaz:
https://doaj.org/article/5513ad7e60df4ce6a1b667ef1841c48e
The idea for convening a Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy was born in an assembly of researchers from the Vermont Regional Cancer Center and the Norris Cotton Cancer Center who shared a common i
The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used
Autor:
L. Fiocchi, G. Pezzoni, C. E. Gallagher, E. Menta, A. P. Krapcho, M E Maresch, S. Spinelli, Miles P. Hacker, R. Di Domenico, F. C. Giuliani, Ambrogio Oliva, Gino Beggiolin
Publikováno v:
Journal of Medicinal Chemistry. 41:5429-5444
The synthesis and antitumor evaluation of 2, 5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-APs) are described. The key intermediates in the synthesis are benz[g]isoquinoline-5,10-diones which are substituted at positions 6 and 9 with