Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Miles E. Matsen"'
Autor:
Jenny M. Brown, Marie A. Bentsen, Dylan M. Rausch, Bao Anh Phan, Danielle Wieck, Huzaifa Wasanwala, Miles E. Matsen, Nikhil Acharya, Nicole E. Richardson, Xin Zhao, Peng Zhai, Anna Secher, Gregory J. Morton, Tune H. Pers, Michael W. Schwartz, Jarrad M. Scarlett
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102944- (2021)
Summary: The capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that follo
Externí odkaz:
https://doaj.org/article/a1885c63ccdc425c86713ffd2aa00662
Autor:
Mauricio D. Dorfman, Jordan E. Krull, John D. Douglass, Rachael Fasnacht, Fernando Lara-Lince, Thomas H. Meek, Xiaogang Shi, Vincent Damian, Hong T. Nguyen, Miles E. Matsen, Gregory J. Morton, Joshua P. Thaler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mec
Externí odkaz:
https://doaj.org/article/c3d9bcc58c004e1b9f6eb255e257f3c4
Autor:
Jennifer M. Rojas, Miles E. Matsen, Thomas O. Mundinger, Gregory J. Morton, Darko Stefanovski, Richard N. Bergman, Karl J. Kaiyala, Gerald J. Taborsky Jr., Michael W. Schwartz
Publikováno v:
Molecular Metabolism, Vol 4, Iss 8, Pp 561-568 (2015)
Objective: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intrac
Externí odkaz:
https://doaj.org/article/74f0c344eb9a4833b43c5ebf5ed857d8
Autor:
Nikhil K. Acharya, Jenny M. Brown, Bao Anh Phan, Danielle Wieck, Miles E. Matsen, Dylan M. Rausch, Marie A. Bentsen, Huzaifa Wasanwala, Anna Secher, Peng Zhai, Tune H. Pers, Jarrad M. Scarlett, Nicole E. Richardson, Xin Zhao, Michael W. Schwartz, Gregory J. Morton
Publikováno v:
iScience
Brown, J M, Bentsen, M A, Rausch, D M, Phan, B A, Wieck, D, Wasanwala, H, Matsen, M E, Acharya, N, Richardson, N E, Zhao, X, Zhai, P, Secher, A, Morton, G J, Pers, T H, Schwartz, M W & Scarlett, J M 2021, ' Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission ', iScience, vol. 24, no. 9, 102944 . https://doi.org/10.1016/j.isci.2021.102944
iScience, Vol 24, Iss 9, Pp 102944-(2021)
Brown, J M, Bentsen, M A, Rausch, D M, Phan, B A, Wieck, D, Wasanwala, H, Matsen, M E, Acharya, N, Richardson, N E, Zhao, X, Zhai, P, Secher, A, Morton, G J, Pers, T H, Schwartz, M W & Scarlett, J M 2021, ' Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission ', iScience, vol. 24, no. 9, 102944 . https://doi.org/10.1016/j.isci.2021.102944
iScience, Vol 24, Iss 9, Pp 102944-(2021)
Summary The capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that follow
Autor:
Nikhil K. Acharya, Gregory J. Morton, Miles E. Matsen, Michael W. Schwartz, Richard N. Bergman, Darko Stefanovski, Kenjiro Muta
Publikováno v:
Brain Research. 1710:136-145
Normal glucose homeostasis depends on the capacity of pancreatic β-cells to adjust insulin secretion in response to a change of tissue insulin sensitivity. In cold environments, for example, the dramatic increase of insulin sensitivity required to e
Autor:
Rasmus Jorgensen, Michael W. Schwartz, Jarrad M. Scarlett, Gregory J. Morton, Anna Secher, Jenny M. Brown, Miles E. Matsen, Hong T. Nguyen
Publikováno v:
Diabetes
University of Copenhagen
University of Copenhagen
In rodent models of type 2 diabetes (T2D), sustained remission of diabetic hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1). To identify the brain areas responsible for this effect,
Autor:
Kenjiro Muta, Rasmus Jorgensen, Karl J. Kaiyala, Masakazu Shiota, Gregory J. Morton, Darko Stefanovski, Jennifer M. Rojas, Richard N. Bergman, Francesca Piccinini, Jarrad M. Scarlett, Jenny M. Brown, Thomas Hoeg-Jensen, Camilla Ingvorsen, Michael W. Schwartz, Nikhil K. Acharya, Anna Secher, Miles E. Matsen
Publikováno v:
Diabetes
We recently reported that in rodent models of type 2 diabetes (T2D), a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces remission of hyperglycemia that is sustained for weeks. To clarify the peripheral mecha
Autor:
Jenny M. Brown, Gregory J. Morton, Jarrad M. Scarlett, Anna Secher, Michael W. Schwartz, Marie A. Bentsen, Tune H. Pers, Nicole E. Richardson, Dylan M. Rausch, Nikhil K. Acharya, Danielle Wieck, Huzaifa Wasanwala, Miles E. Matsen, Xin Zhao, Bao Anh Phan, Peng Zhai
Publikováno v:
SSRN Electronic Journal.
The capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that following icv
Autor:
Gregory J. Morton, Tune H. Pers, Nicole E. Richardson, Xin Zhao, Bao Anh Phan, Michael W. Schwartz, Jarrad M. Scarlett, Huzaifa Wasanwala, Anna Secher, Marie A. Bentsen, Danielle Wieck, Peng Zhai, Miles E. Matsen, Dylan M. Rausch, Jenny M. Brown
SummaryThe capacity of the brain to elicit sustained remission of hyperglycemia in rodent models of type 2 diabetes following intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) is well established. Here, we show that followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7d1cf70dcb636cce2f2e0c1cb7a57e
https://doi.org/10.1101/2020.12.24.424313
https://doi.org/10.1101/2020.12.24.424313
Autor:
Anna Secher, Jenny M. Brown, Bao Anh N. Phan, Miles E. Matsen, Jarrad M. Scarlett, Gregory J. Morton, Huzaifa Wasanwala, Michael W. Schwartz
Publikováno v:
Diabetes. 69
The hypothalamic arcuate nucleus-median eminence (ARC-ME) is a target for sustained diabetes remission induced by fibroblast growth factor 1 (FGF1). To identify intracellular signaling cascades underlying this effect, we considered evidence that sust