Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Miles C Scotcher"'
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11047 (2010)
Botulinum neurotoxin (BoNT), the causative agent of botulism, a serious neuroparylatic disease, is produced by the anaerobic bacterium Clostridium botulinum and consists of a family of seven serotypes (A-H). We previously reported production of high-
Externí odkaz:
https://doaj.org/article/21f389a43a5241229518aefaaa527f65
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4924 (2009)
BACKGROUND: Botulism, an often fatal neuroparalytic disease, is caused by botulinum neurotoxins (BoNT) which consist of a family of seven serotypes (A-H) produced by the anaerobic bacterium Clostridium botulinum. BoNT, considered the most potent biol
Externí odkaz:
https://doaj.org/article/5e7a23fff16547a6958ecd598c808572
Publikováno v:
Toxins
Volume 11
Issue 7
Toxins, Vol 11, Iss 7, p 407 (2019)
Volume 11
Issue 7
Toxins, Vol 11, Iss 7, p 407 (2019)
Botulism is a devastating disease caused by botulinum neurotoxins (BoNTs) secreted primarily by Clostridium botulinum. Mouse bioassays without co-inoculation with antibodies are the standard method for the detection of BoNTs, but are not capable of d
Publikováno v:
Applied and Environmental Microbiology
There is a growing interest in the use of microbial fermentation for the generation of high-demand, high-purity chemicals using cheap feedstocks in an environmentally friendly manner. One example explored here is the production of isoprene (C 5 H 8 )
Autor:
Miles C. Scotcher, Paul Merrill, Larry H. Stanker, Craig Skinner, Xiaohua He, Stephanie McMahon
Publikováno v:
Journal of Immunological Methods. 389:18-28
Human infection by Shiga toxin producing Escherichia coli (STEC) is one of the most prevalent foodborne diseases. Shiga toxin type 2 (Stx2) is the major contributor to hemolytic–uremic syndrome (HUS) and other systemic complications caused by STEC.
Autor:
Luisa W. Cheng, Jeffery A. McGarvey, Larry H. Stanker, Robert Hnasko, Miles C. Scotcher, Kathryn H. Ching
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 32:6-15
Botulinum neurotoxins (BoNT) are produced by Clostridium botulinum and cause severe neuroparalytic disease that if not treated quickly is often fatal. The toxin is produced as a 150 kDa precursor protein (holotoxin) that is enzymatically cleaved to f
Autor:
Robert Hnasko, Jeffery A. McGarvey, Alice Lin, Stanley B. Prusiner, Larry H. Stanker, Miles C. Scotcher
Publikováno v:
Stanker, LH; Scotcher, MC; Lin, A; McGarvey, J; Prusiner, SB; & Hnasko, R. (2012). Novel epitopes identified by anti-PrP monoclonal antibodies produced following immunization of Prnp0/0 balb/cJ mice with purified scrapie prions. Hybridoma, 31(5), 314-324. doi: 10.1089/hyb.2012.0022. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3qd8j99r
Prions, or infectious proteins, cause a class of uniformly fatal neurodegenerative diseases. Prions are composed solely of an aberrantly folded isoform (PrPSc) of a normal cellular protein (PrPC). Shared sequence identity of PrPSc with PrPC has limit
Publikováno v:
Hybridoma. 28:315-325
F1-2 and F1-5 are mouse IgG1 monoclonal antibodies that bind the heavy chain of Botulinum neurotoxin serotype A (BoNT/A). To characterize the epitopes of F1-2 and F1-5, three complementary experimental approaches were selected. First, recombinant pep
Autor:
George N. Bennett, Miles C. Scotcher
Publikováno v:
Journal of Industrial Microbiology & Biotechnology. 35:743-750
In Clostridium acetobutylicum, abrB310 is transcribed from two transcription start sites (designated A1 and A2) forming an abundant large, and a five- to tenfold less abundant small transcript, respectively throughout exponential, acidogenic growth a
Publikováno v:
Applied and Environmental Microbiology. 71:1987-1995
The transcription factors sinR and abrB are involved in the control of sporulation initiation in Bacillus subtilis . We identified a single homologue to sinR and three highly similar homologues to abrB , designated abrB310 , abrB1941 , and abrB3647 ,