Zobrazeno 1 - 10
of 624
pro vyhledávání: '"Miles D. Houslay"'
Autor:
Hanna Jaaro-Peled, Sunil Kumar, Dalton Hughes, Akiko Sumitomo, Sun-Hong Kim, Sandra Zoubovsky, Yuki Hirota-Tsuyada, Diana Zala, Julie Bruyere, Brittany M. Katz, Beverly Huang, Rafael Flores, Soumya Narayan, Zhipeng Hou, Aris N. Economides, Takatoshi Hikida, William C. Wetsel, Karl Deisseroth, Susumu Mori, Nicholas J. Brandon, Motomasa Tanaka, Koko Ishizuka, Miles D. Houslay, Frédéric Saudou, Kafui Dzirasa, Akira Sawa, Toshifumi Tomoda
Publikováno v:
Molecular Psychiatry. 27:1805-1815
Sensorimotor information processing underlies normal cognitive and behavioral traits and has classically been evaluated through prepulse inhibition (PPI) of a startle reflex. PPI is a behavioral dimension deregulated in several neurological and psych
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c5361c7dcda2626d9b38677ea2d8ef
https://doi.org/10.1038/s41380-021-01389-3
https://doi.org/10.1038/s41380-021-01389-3
Autor:
Dianne van Strijp, Christiane de Witz, Birthe Heitkötter, Sebastian Huss, Martin Bögemann, George S. Baillie, Miles D. Houslay, Chris Bangma, Axel Semjonow, Ralf Hoffmann
Publikováno v:
Prostate Cancer, Vol 2019 (2019)
Objectives. To investigate the added value of assessing transcripts for the long cAMP phosphodiesterase-4D (PDE4D) isoforms, PDE4D5 and PDE4D9, regarding the prognostic power of the ‘CAPRA & PDE4D7’ combination risk model to predict longitudinal
Externí odkaz:
https://doaj.org/article/2a81cda05f6f4790873f44fc52c19088
Autor:
Bernat Baeza-Raja, Benjamin D. Sachs, Pingping Li, Frank Christian, Eirini Vagena, Dimitrios Davalos, Natacha Le Moan, Jae Kyu Ryu, Shoana L. Sikorski, Justin P. Chan, Miriam Scadeng, Susan S. Taylor, Miles D. Houslay, George S. Baillie, Alan R. Saltiel, Jerrold M. Olefsky, Katerina Akassoglou
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 255-268 (2016)
Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD). Despite no c
Externí odkaz:
https://doaj.org/article/6df01ed55e9b4e4795aea5d1c5382970
Publikováno v:
Circulation. 146(23)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9049cb8e29ca47f40f63820fe44c50
https://pubmed.ncbi.nlm.nih.gov/36469592
https://pubmed.ncbi.nlm.nih.gov/36469592
Autor:
Robbert Havekes, Alan J Park, Jennifer C Tudor, Vincent G Luczak, Rolf T Hansen, Sarah L Ferri, Vibeke M Bruinenberg, Shane G Poplawski, Jonathan P Day, Sara J Aton, Kasia Radwańska, Peter Meerlo, Miles D Houslay, George S Baillie, Ted Abel
Publikováno v:
eLife, Vol 5 (2016)
Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage. Here, we examine the impact of brief periods of sleep d
Externí odkaz:
https://doaj.org/article/32f1bf3a9ee043e8a3a8e3f02ed72e8f
Publikováno v:
Henderson, D J P, Houslay, M D, Bangma, C H & Hoffmann, R 2019, ' Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7) ', Clinical Science, vol. 133, no. 2, pp. 269-286 . https://doi.org/10.1042/CS20180519
Increased PSA-based screening for prostate cancer has resulted in a growing number of diagnosed cases. However, around half of these are ‘indolent’, neither metastasizing nor leading to disease specific death. Treating non-progressing tumours wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b164ed83bd411534137b98a3e2183f5
https://doi.org/10.1042/cs20180519
https://doi.org/10.1042/cs20180519
Autor:
Sebastian Huss, Birthe Heitkötter, Miles D. Houslay, Ralf Hoffmann, Christiane de Witz, Dianne Arnoldina Margaretha Wilhelmina Van Strijp, Axel Semjonow, Chris H. Bangma, Martin Bögemann, George S. Baillie
Publikováno v:
Prostate Cancer
Prostate Cancer, Vol 2019 (2019)
Prostate Cancer. Hindawi Limited
Van Strijp, D, De Witz, C, Heitkötter, B, Huss, S, Bögemann, M, Baillie, G S, Houslay, M D, Bangma, C, Semjonow, A & Hoffmann, R 2019, ' The association of the long prostate cancer expressed PDE4D transcripts to poor patient outcome depends on the tumour's TMPRSS2-ERG fusion status ', Prostate Cancer, vol. 2019, 8107807 . https://doi.org/10.1155/2019/8107807
Prostate Cancer, Vol 2019 (2019)
Prostate Cancer. Hindawi Limited
Van Strijp, D, De Witz, C, Heitkötter, B, Huss, S, Bögemann, M, Baillie, G S, Houslay, M D, Bangma, C, Semjonow, A & Hoffmann, R 2019, ' The association of the long prostate cancer expressed PDE4D transcripts to poor patient outcome depends on the tumour's TMPRSS2-ERG fusion status ', Prostate Cancer, vol. 2019, 8107807 . https://doi.org/10.1155/2019/8107807
Objectives. To investigate the added value of assessing transcripts for the long cAMP phosphodiesterase-4D (PDE4D) isoforms, PDE4D5 and PDE4D9, regarding the prognostic power of the ‘CAPRA & PDE4D7’ combination risk model to predict longitudinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1c1d6381c07081353c0b3a265b1927
http://europepmc.org/articles/PMC6582815
http://europepmc.org/articles/PMC6582815
Publikováno v:
Journal of Biological Chemistry. 295:12328
β-Arrestin plays a key role in regulating β2-adrenoreceptor signaling by interdicting activation of adenylyl cyclase and selectively sequestering cAMP phosphodiesterase-4D5 (PDE4D5) for delivery of an active cAMP degrading system to the site of cAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971ec71a2e1111811d042333fbf05953
https://doi.org/10.1074/jbc.w120.015374
https://doi.org/10.1074/jbc.w120.015374
Autor:
Brittany M. Katz, Motomasa Tanaka, Aris N. Economides, Akiko Sumitomo, Susumu Mori, Rafael Flores, Sandra Zoubovsky, Beverly Huang, Kafui Dzirasa, Frédéric Saudou, Akira Sawa, Karl Deisseroth, Julie Bruyère, Toshifumi Tomoda, Koko Ishizuka, William C. Wetsel, Takatoshi Hikida, Dalton Hughes, Soumya Narayan, Diana Zala, Miles D. Houslay, Sunil Kumar, Sun Hong Kim, Zhipeng Hou, Nicholas J. Brandon, Hanna Jaaro-Peled, Yuki Hirota-Tsuyada
Sensorimotor information processing that underlies normal cognitive and behavioral traits is dysregulated across a subset of neurological and psychiatric disorders. The cross-disease deficit in sensorimotor gating poses a unique opportunity to integr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c51fe3799e69d4dfec56dc8fab7bbf5
https://doi.org/10.1101/497446
https://doi.org/10.1101/497446
Autor:
Christiane de Witz, Janneke Wrobel, Sebastian Huss, Anne van Brussel, Birthe Heitkötter, Ralf Hoffmann, Pieter C. Vos, Chris H. Bangma, Pierre Tennstedt, Thorsten Schlomm, Eveline den Biezen-Timmermans, Dianne Arnoldina Margaretha Wilhelmina Van Strijp, Martin Bögemann, Miles D. Houslay, Axel Semjonow, George S. Baillie
Publikováno v:
Van Strijp, D, De Witz, C, Vos, P C, Den Biezen-Timmermans, E, Van Brussel, A, Wrobel, J, Baillie, G S, Tennstedt, P, Schlomm, T, Heitkötter, B, Huss, S, Bögemann, M, Houslay, M D, Bangma, C, Semjonow, A & Hoffmann, R 2018, ' The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes ', Prostate Cancer, vol. 2018, 5821616 . https://doi.org/10.1155/2018/5821616
Prostate Cancer. Hindawi Limited
Prostate Cancer
Prostate Cancer. Hindawi Limited
Prostate Cancer
Purpose.To further validate the prognostic power of the biomarker PDE4D7, we investigated the correlation of PDE4D7 scores adjusted for presurgical clinical variables with longitudinal postsurgical biological outcomes.Methods.RNA was extracted from b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d471609761f3e3dda2de35fe8118f89b
https://kclpure.kcl.ac.uk/en/publications/2a75149f-0583-487b-8242-0cb89dd0951b
https://kclpure.kcl.ac.uk/en/publications/2a75149f-0583-487b-8242-0cb89dd0951b