Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Milena Schönke"'
Autor:
Xiaoke Ge, Bram Slütter, Joost M. Lambooij, Enchen Zhou, Zhixiong Ying, Ceren Agirman, Marieke Heijink, Antoine Rimbert, Bruno Guigas, Johan Kuiper, Christoph Müller, Franz Bracher, Martin Giera, Sander Kooijman, Patrick C.N. Rensen, Yanan Wang, Milena Schönke
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109830- (2024)
Summary: The liver X receptor (LXR) is considered a therapeutic target for atherosclerosis treatment, but synthetic LXR agonists generally also cause hepatic steatosis and hypertriglyceridemia. Desmosterol, a final intermediate in cholesterol biosynt
Externí odkaz:
https://doaj.org/article/d72d912914924864b6d5ff9166b6b6a7
Autor:
Borja Martinez-Tellez, Guillermo Sanchez-Delgado, Francisco M. Acosta, Juan M. A. Alcantara, Francisco J. Amaro-Gahete, Wendy D. Martinez-Avila, Elisa Merchan-Ramirez, Victoria Muñoz-Hernandez, Francisco J. Osuna-Prieto, Lucas Jurado-Fasoli, Huiwen Xu, Lourdes Ortiz-Alvarez, María J. Arias-Tellez, Andrea Mendez-Gutierrez, Idoia Labayen, Francisco B. Ortega, Milena Schönke, Patrick C. N. Rensen, Concepción M. Aguilera, José M. Llamas-Elvira, Ángel Gil, Jonatan R. Ruiz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Exercise modulates brown adipose tissue (BAT) metabolism in murine models. Here the authors report that there is no evidence that 24 weeks of supervised exercise training modulates BAT volume or function in young sedentary adults in the ACTIBATE rand
Externí odkaz:
https://doaj.org/article/423225690a6c49afaa79539a8376bd23
Autor:
Wietse In Het Panhuis, Milena Schönke, Melanie Modder, Hannah E. Tom, Reshma A. Lalai, Amanda C.M. Pronk, Trea C.M. Streefland, Linda W.M. van Kerkhof, Martijn E.T. Dollé, Marie A.C. Depuydt, Ilze Bot, Winnie G. Vos, Laura A. Bosmans, Bram W. van Os, Esther Lutgens, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104680- (2023)
Summary: Background: Circadian disturbance (CD) is the consequence of a mismatch between endogenous circadian rhythms, behaviour, and/or environmental cycles, and frequently occurs during shift work. Shift work has been associated with elevated risk
Externí odkaz:
https://doaj.org/article/7688df68c73a447fbd0ed5759e20db0d
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/3dca53486bc14c42b4e4ddf95f6e9ebe
Autor:
Cong Liu, Milena Schönke, Borah Spoorenberg, Joost M Lambooij, Hendrik JP van der Zande, Enchen Zhou, Maarten E Tushuizen, Anne-Christine Andreasson, Andrew Park, Stephanie Oldham, Martin Uhrbom, Ingela Ahlstedt, Yasuhiro Ikeda, Kristina Wallenius, Xiao-Rong Peng, Bruno Guigas, Mariëtte R Boon, Yanan Wang, Patrick CN Rensen
Publikováno v:
eLife, Vol 12 (2023)
Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their glucose-lowering and insulin-sensitizing effects have been largely unrav
Externí odkaz:
https://doaj.org/article/10b3762987d94deeac6dedce6336b7ac
Autor:
Sheng Li, Milena Schönke, Jacobus C. Buurstede, Tijmen J.A. Moll, Max Gentenaar, Maaike Schilperoort, Jenny A. Visser, Kasiphak Kaikaew, Davy van de Vijver, Tooba Abbassi-Daloii, Vered Raz, Annemieke Aartsma-Rus, Maaike van Putten, Onno C. Meijer, Jan Kroon
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Muscle atrophy is common in patients with increased glucocorticoid exposure. Glucocorticoid effects are often sex-specific, and while different glucocorticoid responses between male and female subjects are reported, it is unclear why this is. In this
Externí odkaz:
https://doaj.org/article/946e91433eb44975b8e7480eca6ca3bc
Autor:
Robin van Eenige, Wietse In het Panhuis, Milena Schönke, Céline Jouffe, Thomas H. Devilee, Ricky Siebeler, Trea C.M. Streefland, Hetty C.M. Sips, Amanda C.M. Pronk, Ruben H.P. Vorderman, Hailiang Mei, Jan Bert van Klinken, Michel van Weeghel, Nina H. Uhlenhaut, Sander Kersten, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101497- (2022)
Objective: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metab
Externí odkaz:
https://doaj.org/article/06c92daf305441edabcfb8bb607a0144
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1276-1282 (2018)
Metabolic flexibility, the capacity to adapt to fuel availability for energy production, is crucial for maintaining whole-body energy homeostasis. An inability to adequately promote FA utilization is associated with lipid accumulation in peripheral t
Externí odkaz:
https://doaj.org/article/1b52f25242db4d829a93698e9afc4deb
Autor:
Louise Mannerås-Holm, Milena Schönke, Joseph T. Brozinick, Laurène Vetterli, Hai-Hoang Bui, Philip Sanders, Emmani B.M. Nascimento, Marie Björnholm, Alexander V. Chibalin, Juleen R. Zierath
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 907-915 (2017)
Diacylglycerol kinases (DGKs) catalyze the phosphorylation and conversion of diacylglycerol (DAG) into phosphatidic acid. DGK isozymes have unique primary structures, expression patterns, subcellular localizations, regulatory mechanisms, and DAG pref
Externí odkaz:
https://doaj.org/article/2bf3b5d7e0a349b4bf872fc42ccb5f83
Autor:
Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 636-646 (2017)
Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order
Externí odkaz:
https://doaj.org/article/aa11d88b9e6d4a64a80f36f80d98b06d