Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK)

Autor: Milena Rossmanith, Jan Engelmann, Nils C. Gassen, Marianne B. Müller, Natarajan Perumal, Michael A. van der Kooij, Giulia Treccani, Annika Hasch, Caroline Manicam, David P. Herzog, Klaus Lieb, Tanja Jene, Jens Nadig, Franz H. Grus

Publikováno v: Neurobiology of Stress, Vol 15, Iss, Pp 100404-(2021)
Neurobiology of Stress, 15:100404
Neurobiology of Stress
Herzog, D P, Perumal, N, Manicam, C, Treccani, G, Nadig, J, Rossmanith, M, Engelmann, J, Jene, T, Hasch, A, van der Kooij, M A, Lieb, K, Gassen, N C, Grus, F H & Müller, M B 2021, ' Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK) ', Neurobiology of Stress, vol. 15, 100404 . https://doi.org/10.1016/j.ynstr.2021.100404

Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown.

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http://www.sciencedirect.com/science/article/pii/S2352289521001120