Výsledky vyhledávání - "Milena J. Tosiek"

Akademický článek

Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages’ Function but Does Not Trigger the Adaptive T Cell Immune Response

Autor: Milena J. Tosiek, Kerstin Groesser, Anton Pekcec, Monika Zwirek, Gavuthami Murugesan, Eric Borges

Publikováno v: Journal of Immunology Research, Vol 2022 (2022)

C-Type lectin receptor 5A (CLEC5A) is a spleen tyrosine kinase- (Syk-) coupled pattern recognition receptor expressed on myeloid cells and involved in the innate immune response to viral and bacterial infections. Activation of the CLEC5A receptor wit

Externí odkaz: https://doaj.org/article/f951283ca4f54a589105c9465dface2f

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Akademický článek

IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease

Autor: Milena J. Tosiek, Laurence Fiette, Sary El Daker, Gérard Eberl, Antonio A. Freitas

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Transcription factors directing T cell fate are induced by instructive signals such as cytokines. Here the authors show that IL-15 promotes Foxp3 and inhibits RORγt expression in CD4 T cells, and that IL-15 is critical to suppress colitis by maintai

Externí odkaz: https://doaj.org/article/3dc67ae9efce4f0fb99eca4bbf7248f0

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CD8+ T Cells Responding to Alveolar Self-Antigen Lack CD25 Expression and Fail to Precipitate Autoimmunity

Autor: Milena J. Tosiek, Marcus Gereke, Dunja Bruder, Jan Buer, Sophie R. Bader, Achim D. Gruber

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 47:869-878

Although the contribution of CD8(+) T cells to the pathogenesis of noncommunicable lung diseases has become increasingly appreciated, our knowledge about the mechanisms controlling self-reactive CD8(+) T cells in the respiratory tract remains largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84c0c8497f9ecd1f30f4809f2902800
https://doi.org/10.1165/rcmb.2011-0387oc

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