Výsledky vyhledávání - "Milena Crosato"

HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor

Autor: Milena Crosato, Nicholas Bertos, Nadine Pelletier, Jiahuai Han, Henry H.Q. Heng, Marko Vezmar, Xiang-Jiao Yang, Audrey H. Wang, John Th'ng

Publikováno v: Molecular and Cellular Biology. 19:7816-7827

Histone acetylation plays an important role in regulating chromatin structure and thus gene expression. Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26a4981a22d349c81d6998c790f81bf
https://doi.org/10.1128/mcb.19.11.7816

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Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors

Autor: Pnina Brodt, Diana E. Jaalouk, Milena Crosato, Jacques Galipeau

Publikováno v: Virology Journal
Virology Journal, Vol 3, Iss 1, p 27 (2006)

Background Self-inactivating retroviral vectors (SIN) are often associated with very low titers. Promoter elements embedded within SIN designs may suppress transcription of packageable retroviral RNA which in turn results in titer reduction. We teste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1da461e77a15925d67b057499aaaba0
https://doi.org/10.1186/1743-422x-3-27

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A neovascularized organoid derived from retrovirally engineered bone marrow stroma leads to prolonged in vivo systemic delivery of erythropoietin in nonmyeloablated, immunocompetent mice

Autor: Kevin Lachapelle, Abdulaziz Al-Khaldi, Jacques Galipeau, Nicoletta Eliopoulos, Milena Crosato

Publikováno v: Gene therapy. 10(6)

Marrow stromal cells (MSCs) are postnatal progenitor cells that can be easily cultured ex vivo to large amounts. This feature is attractive for cell therapy applications where genetically engineered MSCs could serve as an autologous cellular vehicle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e2cf34750130dd7c0f197241e2eb49
https://pubmed.ncbi.nlm.nih.gov/12621452

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Processing of amyloid precursor protein in human primary neuron and astrocyte cultures

Autor: Caroline Bélair, Maria Papadopoulos, William Chu, Jaqueline Powell, Milena Crosato, Andréa C. LeBlanc, Cynthia G. Goodyer

Publikováno v: Journal of neurochemistry. 68(3)

Increased production of amyloid beta peptide (A beta) is highly suspected to play a major role in Alzheimer's disease (AD) pathogenesis. Because A beta deposits in AD senile plaques appear uniquely in the brain and are fairly restricted to humans, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52703ffddb06b8bbf5054c622e7ce8bf
https://pubmed.ncbi.nlm.nih.gov/9048765

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