Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Milena B P, Soares"'
Autor:
Ingrid R. S. B. Dias, Rafaela G. A. Costa, Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Lauren V. Cairns, Ken I. Mills, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Acute myeloid leukaemia (AML) is a lethal bone marrow neoplasm caused by genetic alterations in blood cell progenitors. Leukaemic stem cells (LSCs) are responsible for the development of AML, drug resistance and relapse. Bithionol is an old
Externí odkaz:
https://doaj.org/article/8802be9e97fa4560b21e60e2788a7cd9
Autor:
Larissa M. Bomfim, Sara P. Neves, Amanda M. R. M. Coelho, Mateus L. Nogueira, Rosane B. Dias, Ludmila de F. Valverde, Clarissa A. G. Rocha, Milena B. P. Soares, Alzir A. Batista, Rodrigo S. Correa, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Cancer stem cells (CSCs) are defined as a rare population of cancer cells related to tumor initiation and maintenance. These cells are primarily responsible for tumor growth, invasion, metastasis, recurrence, and resistance to chemotherapy.
Externí odkaz:
https://doaj.org/article/63a439c6ac1e4c5aab3ab93b75fd2589
Autor:
Suellen L. R. Silva, Ingrid R. S. B. Dias, Ana Carolina B. da C. Rodrigues, Rafaela G. A. Costa, Maiara de S. Oliveira, Gabriela A. da C. Barbosa, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Nainita Roy, Christopher Y. Park, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effe
Externí odkaz:
https://doaj.org/article/07013829e0064a6b9da30cd661ecddb5
Autor:
Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Ingrid R. S. B. Dias, Rafaela G. A. Costa, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Emily M. Johnson, Cristina Pina, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Acute myeloid leukaemia (AML) is a haematological malignancy characterised by the accumulation of transformed myeloid progenitors in the bone marrow. Piplartine (PL), also known as piperlongumine, is a pro-oxidant small molecule extracted fr
Externí odkaz:
https://doaj.org/article/45153271df08471280ba301d8a84973f
Autor:
Diego C. Carneiro, Vinícius P. C. Rocha, Patrícia K. F. Damasceno, Josiane D. V. Barbosa, Milena B. P. Soares
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
A significant limitation of numerous current genetic engineering therapy approaches is their limited control over the strength, timing, or cellular context of their therapeutic effect. Synthetic gene/genetic circuits are synthetic biology approaches
Externí odkaz:
https://doaj.org/article/5f8a528e8af7479d85353ba072c8b178
Autor:
Valdenizia R. Silva, Luciano de S. Santos, Maria V. L. de Castro, Rosane B. Dias, Ludmila de F. Valverde, Clarissa A. G. Rocha, Milena B. P. Soares, Claudio A. Quadros, Rodrigo S. Correa, Alzir A. Batista, Daniel P. Bezerra
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract [Ru(5-FU)(PPh3)2(bipy)]PF6 (Ru/5-FU) is a novel ruthenium complex with 5-fluorouracil with promising potential against colorectal cancer (CRC). In the present study, we investigated the molecular mechanism of Ru/5-FU action in HCT116 CRC cel
Externí odkaz:
https://doaj.org/article/55b2ba52b0974d398bd5bd355686c8dc
Autor:
Luciano de S. Santos, Valdenizia R. Silva, Maria V. L. de Castro, Rosane B. Dias, Ludmila de F. Valverde, Clarissa A. G. Rocha, Milena B. P. Soares, Claudio A. Quadros, Edjane R. dos Santos, Regina M. M. Oliveira, Rose M. Carlos, Paulo C. L. Nogueira, Daniel P. Bezerra
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-15 (2023)
Abstract In this work, we describe a novel ruthenium-xanthoxylin complex, [Ru(phen)2(xant)](PF6) (RXC), that can eliminate colorectal cancer (CRC) stem cells by targeting the chaperone Hsp90. RXC exhibits potent cytotoxicity in cancer cell lines and
Externí odkaz:
https://doaj.org/article/82e911c832d94a74b26664b3ae72a376
Autor:
Carolina T. Macedo, Ticiana F. Larocca, Márcia Noya-Rabelo, Roque Aras, Cristiano R. B. Macedo, Moisés I. Moreira, Alessandra C. Caldas, Jorge A. Torreão, Victor M. A. Monsão, Clarissa L. M. Souza, Juliana F. Vasconcelos, Milena R. Bezerra, Daniela P. Petri, Bruno S. F. Souza, Antônio G. F. Pacheco, André Daher, Ricardo Ribeiro-dos-Santos, Milena B. P. Soares
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
AimPrevious studies showed that granulocyte-colony stimulating factor (G-CSF) improved heart function in a mice model of Chronic Chagas Cardiomyopathy (CCC). Herein, we report the interim results of the safety and efficacy of G-CSF therapy vs. placeb
Externí odkaz:
https://doaj.org/article/007d5e446cfb451eb55472d5c745101e
Autor:
Milena B. P. Soares, Renata G. J. Gonçalves, Juliana F. Vasques, Almir J. da Silva-Junior, Fernanda Gubert, Girlaine Café Santos, Thaís Alves de Santana, Gabriela Louise Almeida Sampaio, Daniela Nascimento Silva, Massimo Dominici, Rosalia Mendez-Otero
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neurological disorders include a wide spectrum of clinical conditions affecting the central and peripheral nervous systems. For these conditions, which affect hundreds of millions of people worldwide, generally limited or no treatments are available,
Externí odkaz:
https://doaj.org/article/50c9cf848cf44dd1b08bee47fbfd76c8
Autor:
Diogo E. L. Carvalho, Katia M. Oliveira, Larissa M. Bomfim, Milena B. P. Soares, Daniel P. Bezerra, Alzir A. Batista, Rodrigo S. Correa
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 122-130 (2020)
Externí odkaz:
https://doaj.org/article/75fd1531bf3a4ecfad4728b7ca2e4436