Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Mildred A, Duncan"'
Autor:
Christopher A. Apostolatos, Wishrawana S. Ratnayake, Sloan Breedy, Jacqueline Kai Chin Chuah, James Alastair Miller, Daniele Zink, Marie Bourgeois, Mildred Acevedo-Duncan
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 2, Pp 368-379 (2024)
Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma cells. Previous in vitro studies have shown that 5-amino-1-((1R,2S,3R,4R)-2-3-dihydroxy-4-(hydroxymethyl)cyclop
Externí odkaz:
https://doaj.org/article/1824df5ae6f9488594a24a1a75f2bc46
Autor:
Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Mildred Acevedo-Duncan
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundRenal Cell Carcinoma (RCC) is the most common type of kidney cancer (85%). 75% of the RCC cases involve conventional clear cell RCC (ccRCC). Approximately, 39% of late-stage patients (stage IV) are treated with chemotherapeutic agents. Phos
Externí odkaz:
https://doaj.org/article/4e36e424476d41c5accfad41adc37d21
Autor:
Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo‐Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese
Publikováno v:
MedComm, Vol 2, Iss 1, Pp 3-16 (2021)
Abstract Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic a
Externí odkaz:
https://doaj.org/article/ec1d5d225cae4de1b000248920a5fece
Autor:
Wishrawana S. Ratnayake, Christopher A. Apostolatos, Sloan Breedy, Clare L. Dennison, Robert Hill, Mildred Acevedo-Duncan
Publikováno v:
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 37-57 (2021)
Atypical protein kinase C (aPKC) are involved in progression of many human cancers. Vimentin is expressed during epithelial to mesenchymal transition (EMT). Molecular dynamics of Vimentin intermediate filaments (VIFs) play a key role in metastasis. T
Externí odkaz:
https://doaj.org/article/80dd4008f3894e1fbffe3bfd1f7b3d74
Autor:
S M Anisul Islam, Rekha Patel, Raja Reddy Bommareddy, Khandker Mohammad Khalid, Mildred Acevedo-Duncan
Publikováno v:
Cell Adhesion & Migration, Vol 13, Iss 1, Pp 106-120 (2019)
Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the f
Externí odkaz:
https://doaj.org/article/330f01d3cd674f578a5fc26a3b7b0380
Autor:
Tracess Smalley, Rainer Metcalf, Rekha Patel, S. M. Anisul Islam, Raja Reddy Bommareddy, Mildred Acevedo-Duncan
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ovarian cancer is estimated to reach 22,530 diagnoses and cause 13,980 cancer deaths per year. The most common histology diagnosed of ovarian cancer is epithelial ovarian carcinomas (EOC). An aggressive epithelial subtype is clear cell ovarian carcin
Externí odkaz:
https://doaj.org/article/3a64076844554605af749deabd02eada
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 121, Iss , Pp 109665- (2020)
Colorectal cancer (CRC) is the third most common malignancy and the fourth most common cause of cancer-related death worldwide. The treatment of metastatic CRC considered palliative for many years aiming for an improved life, with little hope of a cu
Externí odkaz:
https://doaj.org/article/7b88ee37c59242b0aeffddb4f9377f3a
Autor:
Mini P, Sajan, Michael, Leitges, Colin, Park, David M, Diamond, Jin, Wu, Barbara C, Hansen, Mildred A, Duncan, Christopher A, Apostolatos, Andre H, Apostolatos, Mark, Kindy, Robert V, Farese
Publikováno v:
Current Alzheimer Research. 18:941-955
Βackground: β-Amyloid precursor protein-cleaving enzyme-1 (BACE1) initiates the production of Aβ-peptides that form Aβ-plaque in Alzheimer’s disease. Methods: Reportedly, acute insulin treatment in normal mice, and hyperinsulinemia in high-fat-
Autor:
Barbara C. Hansen, Robert V. Farese, Denise R. Cooper, Mildred Acevedo-Duncan, Mark S. Kindy, Mini P. Sajan
Publikováno v:
MedComm, Vol 2, Iss 1, Pp 3-16 (2021)
MedComm
MedComm
Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic atypical P
Autor:
Harsh Vardhan, Ayman Nafady, Abdullah M. Al-Enizi, Khalid Khandker, Hussein M. El-Sagher, Gaurav Verma, Mildred Acevedo-Duncan, Tawfiq M. Alotaibi, Shengqian Ma
Publikováno v:
Molecules, Vol 24, Iss 12, p 2284 (2019)
Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a
Externí odkaz:
https://doaj.org/article/63af290de5db4478948ff73f904fbfb3