Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Milazzo FM"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Chiara Giommarelli, Alberto Bargiotti, Claudio Pisano, Michelandrea De Cesare, Andrea Ciacci, Franco Zunino, Ferdinando Maria Milazzo, Massimo Castorina, Giuseppe Giannini, Loana Musso, Sergio Penco, Loredana Vesci, Lucio Merlini, Maria Luisa Cervoni, Valentina Zuco, Marcella Barbarino, Sabrina Dallavalle, Grazia Gallo, Walter Cabri
A series of 3-aryl-naphtho[2,3-d]isoxazole-4,9-diones and some of their 6-aza analogues were Synthesized and found to inhibit the heat shock protein 90 (Hsp90). The compounds were tested for their binding to Hsp90 and for their effects on Hsp90 clien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675e0ce8eaa63e9959cce76565b86fc3
http://hdl.handle.net/11585/756780
http://hdl.handle.net/11585/756780
Autor:
Maria Luisa Cervoni, Tiziana Brunetti, Walter Cabri, Mario B. Guglielmi, Giuseppina Grisolia, Loredana Vesci, Giuseppina Barbato, Rosanna Foderà, Ferdinando Maria Milazzo, Andrea Ciacci, Stefania Mangiola, Claudio Pisano, Massimo Castorina, Grazia Gallo, Giuseppe Giannini, Riccardo Rondanin, Paolo Marchetti, Daniele Simoni, Riccardo Baruchello, Marcella Barbarino, Domenico Alloatti
Publikováno v:
Journal of medicinal chemistry. 54(24)
A structural investigation on the isoxazole scaffold led to the discovery of 3,4-isoxazolediamide compounds endowed with potent Hsp90 inhibitory properties. We have found that compounds possessing a nitrogen atom directly attached to the C-4 heterocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071a2ef8e6366a930539f362c5d9fa98
https://pubmed.ncbi.nlm.nih.gov/22066525
https://pubmed.ncbi.nlm.nih.gov/22066525
Autor:
Lima JFC; São Leopoldo Mandic Institute and Dental Research Center, Campinas, São Paulo, Brazil., Santos FM; Dental Research Division, Paulista University, Rua Doutor Bacelar, 1212, Sao Paulo 04026-002, Brazil., de Miranda TB; Dental Research Division, Paulista University, Rua Doutor Bacelar, 1212, Sao Paulo 04026-002, Brazil., Ramos GG; São Leopoldo Mandic Institute and Dental Research Center, Campinas, São Paulo, Brazil., Andia DC; Dental Research Division, Paulista University, Rua Doutor Bacelar, 1212, Sao Paulo 04026-002, Brazil. Electronic address: denise.andia@docente.unip.br., Lima AF; Dental Research Division, Paulista University, Rua Doutor Bacelar, 1212, Sao Paulo 04026-002, Brazil. Electronic address: lima.adf@gmail.com., Ciotti DL; São Leopoldo Mandic Institute and Dental Research Center, Campinas, São Paulo, Brazil. Electronic address: danilolciotti@gmail.com.
Publikováno v:
Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2024 Nov; Vol. 40 (11), pp. 2025-2033. Date of Electronic Publication: 2024 Oct 02.
Autor:
Milazzo FM; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Chaves-Sanjuan A; Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy; Cryo-EM Lab, Pediatric Research Center, Fondazione Romeo e Enrica Invernizzi, University of Milan, Via Celoria 26, 20133 Milan, Italy., Minenkova O; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Santapaola D; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Anastasi AM; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Battistuzzi G; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Chiapparino C; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Rosi A; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Merlo Pich E; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Albertoni C; Studio E Roma S.r.l., Via di Tor Vergata 434, 00133 Rome, Italy., Marra E; Takis Srl, Via di Castel Romano 100, 00128 Rome, Italy., Luberto L; Takis Srl, Via di Castel Romano 100, 00128 Rome, Italy., Viollet C; Texcell, Génavenir 5, Rue Pierre Fontaine 1, 91058 Evry Cedex, France., Spagnoli LG; Histo-Cyto Service Srl, Via Bernardino Ramazzini 93, 00151 Rome, Italy., Riccio A; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy., Rossi A; Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere 100, 00133 Rome, Italy., Santoro MG; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy; Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere 100, 00133 Rome, Italy., Ballabio F; Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy., Paissoni C; Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy., Camilloni C; Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy., Bolognesi M; Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy; Cryo-EM Lab, Pediatric Research Center, Fondazione Romeo e Enrica Invernizzi, University of Milan, Via Celoria 26, 20133 Milan, Italy., De Santis R; Biotechnology R&D, Alfasigma SpA, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy. Electronic address: rita.desantis@alfasigma.com.
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Feb 01; Vol. 31 (2), pp. 362-373. Date of Electronic Publication: 2022 Sep 15.
Autor:
Minenkova O; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Santapaola D; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Milazzo FM; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Anastasi AM; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Battistuzzi G; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Chiapparino C; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Rosi A; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Gritti G; ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127 Bergamo, Italy., Borleri G; ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127 Bergamo, Italy., Rambaldi A; ASST Papa Giovanni XXIII, Piazza OMS, 1, 24127 Bergamo, Italy; Department of Hematology and Oncology, University of Milan, Via Festa del Perdono, 7, 20122 Milan, Italy., Dental C; Texcell, Batiment Genavenir 5, Rue Pierre Fontaine 1, 91058 Evry Cedex, France., Viollet C; Texcell, Batiment Genavenir 5, Rue Pierre Fontaine 1, 91058 Evry Cedex, France., Pagano B; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Naples, Italy., Salvini L; Fondazione Toscana Life Sciences, Via Fiorentina, 1, 53100 Siena, Italy., Marra E; Takis Srl, Via di Castel Romano, 100, 00128 Rome, Italy., Luberto L; Takis Srl, Via di Castel Romano, 100, 00128 Rome, Italy., Rossi A; Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere, 100, 00133 Rome, Italy., Riccio A; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 1, 00133 Rome, Italy., Merlo Pich E; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy., Santoro MG; Institute of Translational Pharmacology, CNR, Via Fosso del Cavaliere, 100, 00133 Rome, Italy; Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 1, 00133 Rome, Italy., De Santis R; Alfasigma SpA, Biotechnology R&D, Via Pontina Km 30.400, Pomezia, 00071 Rome, Italy. Electronic address: rita.desantis@alfasigma.com.
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 May 04; Vol. 30 (5), pp. 1979-1993. Date of Electronic Publication: 2022 Feb 12.
Autor:
Cianferotti C; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy. maurizio.taddei@unisi.it., Faltoni V; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy. maurizio.taddei@unisi.it., Cini E; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy. maurizio.taddei@unisi.it., Ermini E; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy. maurizio.taddei@unisi.it., Migliorini F; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy. maurizio.taddei@unisi.it., Petricci E; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy. maurizio.taddei@unisi.it., Taddei M; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy. maurizio.taddei@unisi.it., Salvini L; Fondazione Toscana Life Science, Via Fiorentina 1, 53100, Siena, Italy., Battistuzzi G; R&D Alfasigma S.p.A., Via Pontina, Km. 30.400, 00071 Pomezia, Roma, Italy. Giuseppe.Giannini@alfasigma.com., Milazzo FM; R&D Alfasigma S.p.A., Via Pontina, Km. 30.400, 00071 Pomezia, Roma, Italy. Giuseppe.Giannini@alfasigma.com., Anastasi AM; R&D Alfasigma S.p.A., Via Pontina, Km. 30.400, 00071 Pomezia, Roma, Italy. Giuseppe.Giannini@alfasigma.com., Chiapparino C; R&D Alfasigma S.p.A., Via Pontina, Km. 30.400, 00071 Pomezia, Roma, Italy. Giuseppe.Giannini@alfasigma.com., De Santis R; R&D Alfasigma S.p.A., Via Pontina, Km. 30.400, 00071 Pomezia, Roma, Italy. Giuseppe.Giannini@alfasigma.com., Giannini G; R&D Alfasigma S.p.A., Via Pontina, Km. 30.400, 00071 Pomezia, Roma, Italy. Giuseppe.Giannini@alfasigma.com.
Publikováno v:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Jan 28; Vol. 57 (7), pp. 867-870.
Autor:
Pala D; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy., Scalvini L; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy., Elisi GM; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy., Lodola A; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy., Mor M; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy., Spadoni G; Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino 'Carlo Bo', Urbino, Italy., Ferrara FF; Takis s.r.l., Roma, Italy., Pavoni E; Takis s.r.l., Roma, Italy., Roscilli G; Takis s.r.l., Roma, Italy., Milazzo FM; R&D Alfasigma S.p.A., Roma, Italy., Battistuzzi G; R&D Alfasigma S.p.A., Roma, Italy., Rivara S; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy., Giannini G; R&D Alfasigma S.p.A., Roma, Italy.
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1685-1696.
Autor:
Milazzo FM; Biotechnology R&D, Alfasigma SpA, Rome, Italy., Vesci L; Biotechnology R&D, Alfasigma SpA, Rome, Italy., Anastasi AM; Biotechnology R&D, Alfasigma SpA, Rome, Italy., Chiapparino C; Biotechnology R&D, Alfasigma SpA, Rome, Italy., Rosi A; Biotechnology R&D, Alfasigma SpA, Rome, Italy., Giannini G; Biotechnology R&D, Alfasigma SpA, Rome, Italy., Taddei M; Dipartimento di Biotecnologia, Chimica e Farmacia, Università degli Studi di Siena, Siena, Italy., Cini E; Dipartimento di Biotecnologia, Chimica e Farmacia, Università degli Studi di Siena, Siena, Italy., Faltoni V; Lead Discovery Siena srl, Siena, Italy., Petricci E; Dipartimento di Biotecnologia, Chimica e Farmacia, Università degli Studi di Siena, Siena, Italy., Battistuzzi G; Biotechnology R&D, Alfasigma SpA, Rome, Italy., Salvini L; Fondazione Toscana Life Sciences, Siena, Italy., Carollo V; Histo-Cyto Service srl, Rome, Italy., De Santis R; Biotechnology R&D, Alfasigma SpA, Rome, Italy.
Publikováno v:
Frontiers in oncology [Front Oncol] 2020 Jan 23; Vol. 9, pp. 1534. Date of Electronic Publication: 2020 Jan 23 (Print Publication: 2019).
Autor:
Esposito E; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo, 81, 20133, Milan, Italy., Vlodavsky I; Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel., Barash U; Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel., Roscilli G; Takis s.r.l., Via Castel Romano 100, I-00128, Roma, Italy., Milazzo FM; R&D Alfasigma S.p.A., Via Pontina Km 30,400, Pomezia, I-00071, Roma, Italy., Giannini G; R&D Alfasigma S.p.A., Via Pontina Km 30,400, Pomezia, I-00071, Roma, Italy. Electronic address: giuseppe.giannini@alfasigma.com., Naggi A; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo, 81, 20133, Milan, Italy. Electronic address: naggi@ronzoni.it.
Publikováno v:
European journal of medicinal chemistry [Eur J Med Chem] 2020 Jan 15; Vol. 186, pp. 111831. Date of Electronic Publication: 2019 Oct 30.