Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression.

Autor: Vitali E; Laboratory of Cellular and Molecular Endocrinology, IRCCS Humanitas Research Hospital, Milan, Italy., Franceschini B; Hepatobiliary Immunopathology Laboratory, IRCCS Humanitas Research Hospital, Milan, Italy., Milana F; Division of Hepatobiliary and General Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Milan, Italy., Soldani C; Hepatobiliary Immunopathology Laboratory, IRCCS Humanitas Research Hospital, Milan, Italy., Polidoro MA; Hepatobiliary Immunopathology Laboratory, IRCCS Humanitas Research Hospital, Milan, Italy., Carriero R; Bioinformatics Unit, IRCCS Humanitas Research Hospital, Milan, Italy., Kunderfranco P; Bioinformatics Unit, IRCCS Humanitas Research Hospital, Milan, Italy., Trivellin G; Laboratory of Cellular and Molecular Endocrinology, IRCCS Humanitas Research Hospital, Milan, Italy., Costa G; Division of Hepatobiliary and General Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Milan, Italy., Milardi G; Hepatobiliary Immunopathology Laboratory, IRCCS Humanitas Research Hospital, Milan, Italy., Di Tommaso L; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Pathology Department, Humanitas Clinical and Research Center-IRCCS, Milan, Italy., Torzilli G; Division of Hepatobiliary and General Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Lleo A; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Division of Internal Medicine and Hepatology, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy., Lania AG; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Endocrinology, Diabetology and Medical Andrology Unit, IRCCS Humanitas Research Hospital, Milan, Italy., Donadon M; Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.; Department of General Surgery, University Maggiore Hospital, Novara, Italy.

Publikováno v: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2024 Feb; Vol. 44 (2), pp. 518-531. Date of Electronic Publication: 2023 Nov 27.

Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency

Autor: Chetta Aa, Georgia Fousteri, Sarah Marktel, Andrea Assanelli, Giuffrida Fp, Darin S, Zoccolillo M, Rita Nano, Andrea Laurenzi, Maria Giovanna Danieli, Simona Piemontese, Davide Montin, Carmela Giancotta, Barcella M, Dionisio F, Sordi, Chiara Azzari, Jolanda Gerosa, Matarese A, Lorenzo Bd, Matteo Trimarchi, Raffaella Melzi, Caterina Cancrini, Bongiovanni L, Claudio Pignata, Immacolata Brigida, Tatiana Jofra, Angelo Vacca, Lorenzo Piemonti, Maryam Omrani, Alessandro Aiuti, Silvia Di Cesare, Giuliana Giardino, Ivan Merelli, Alessandro Plebani, Maurilio Ponzoni, Constantinos Petrovas, Fernando Specchia, Pellegrin, M. P. Cicalese, Milardi G, Francesca Ferrua, Emilia Cirillo, Lougaris, Gigliola Di Matteo, Patrizia Rovere-Querini, Federica Barzaghi, Lucia Pacillo, Rosa Maria Dellepiane, Romano F

BackgroundCommon variable immunodeficiency (CVID) is the most frequent primary antibody deficiency. A significant number of CVID patients are affected by various manifestations of immune dysregulation such as autoimmunity. Follicular T cells cells ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da0090e1b779534e3d0c041d35bfa875
https://doi.org/10.1101/2021.06.15.448353

Phenotypical and molecular landscape of B lymphocytes in patients with Intrahepatic Cholangiocarcinoma

Autor: Milardi, G., Franceschini, B., Camisaschi, C., Costa, G., Soldani, C., Uva, P., Cassani, B., Lleo, A.

Publikováno v: In Digestive and Liver Disease March 2023 55 Supplement 1:S37-S37

Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency.

Autor: Milardi G; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Di Lorenzo B; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Gerosa J; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Barzaghi F; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Di Matteo G; Department of Systems Medicine, University of Rome Tor Vergata, Via Cracovia 50, Rome, 00133, Italy.; Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, Rome, 00165, Italy., Omrani M; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Department of Computer Science, Systems and Communication, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, Milan, 20126, Italy., Jofra T; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Merelli I; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Department of Bioinformatics, Institute for Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, Segrate, 20090, Italy., Barcella M; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Filippini M; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Conti A; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Ferrua F; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Pozzo Giuffrida F; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Dionisio F; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Rovere-Querini P; Department of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Marktel S; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Assanelli A; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Piemontese S; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Brigida I; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Zoccolillo M; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Cirillo E; Department of Translational Medical Sciences, Section of Pediatrics, Federico II University of Naples, Corso Umberto I, 40, 80138, Italy., Giardino G; Department of Translational Medical Sciences, Section of Pediatrics, Federico II University of Naples, Corso Umberto I, 40, 80138, Italy., Danieli MG; Department of Clinical and Molecular Sciences, Marche Polytechnic University of Ancona, Clinica Medica, Via Tronto 10/a, Ancona, 60126, Italy., Specchia F; Department of Pediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Via Giuseppe Massarenti 9, Bologna, 40138, Italy., Pacillo L; Department of Systems Medicine, University of Rome Tor Vergata, Via Cracovia 50, Rome, 00133, Italy.; Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, Rome, 00165, Italy., Di Cesare S; Department of Systems Medicine, University of Rome Tor Vergata, Via Cracovia 50, Rome, 00133, Italy.; Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, Rome, 00165, Italy., Giancotta C; Department of Systems Medicine, University of Rome Tor Vergata, Via Cracovia 50, Rome, 00133, Italy.; Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, Rome, 00165, Italy., Romano F; Pediatric Immunology Division, Department of Pediatrics, Anna Meyer Children's University Hospital, Viale Gaetano Pieraccini 24, Florence, 50139, Italy., Matarese A; Department of Respiratory Medicine, Santi Antonio, Biagio and Cesare Arrigo Hospital, Via Venezia 16, Alessandria, 15121, Italy., Chetta AA; Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Str. dell'Università 12, Parma, 43121, Italy., Trimarchi M; Otorhinolaryngology Unit, Head and Neck Department, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy.; Pathology Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Laurenzi A; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., De Pellegrin M; Unit of Orthopaedics, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy., Darin S; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Montin D; Department of Pediatrics and Public Health, Regina Margherita Hospital, Piazza Polonia 94, Turin, 10126, Italy., Marinoni M; Pediatric Unit, Ospedale 'F. Del Ponte', Via Filippo del Ponte 19, Varese, 21100, Italy., Dellepiane RM; Department of Pediatrics, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Via Francesco Sforza 35, Milan, 20122, Italy., Sordi V; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Lougaris V; Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia, Piazza del Mercato 15, Brescia, 25121, Italy., Vacca A; Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Piazza Umberto I, 1, Bari, 70121, Italy., Melzi R; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Nano R; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Azzari C; Pediatric Immunology Division, Department of Pediatrics, Anna Meyer Children's University Hospital, Viale Gaetano Pieraccini 24, Florence, 50139, Italy., Bongiovanni L; Pathology Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Pignata C; Department of Translational Medical Sciences, Section of Pediatrics, Federico II University of Naples, Corso Umberto I, 40, 80138, Italy., Cancrini C; Department of Systems Medicine, University of Rome Tor Vergata, Via Cracovia 50, Rome, 00133, Italy.; Immune and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, Rome, 00165, Italy., Plebani A; Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia, Piazza del Mercato 15, Brescia, 25121, Italy., Piemonti L; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Faculty of Medicine, University Vita-Salute San Raffaele, Via Olgettina 60, Milan, 20132, Italy., Petrovas C; Tissue Analysis Core, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA., Di Micco R; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Ponzoni M; Pathology Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Faculty of Medicine, University Vita-Salute San Raffaele, Via Olgettina 60, Milan, 20132, Italy., Aiuti A; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Faculty of Medicine, University Vita-Salute San Raffaele, Via Olgettina 60, Milan, 20132, Italy., Cicalese MP; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.; Pathogenesis and therapy of primary immunodeficiencies Unit, San Raffaele Telethon Institute for Gene Therapy, Sr-TIGET, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy., Fousteri G; Division of Immunology, Transplantation, and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy.

Publikováno v: European journal of immunology [Eur J Immunol] 2022 Jul; Vol. 52 (7), pp. 1171-1189. Date of Electronic Publication: 2022 May 29.

Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes.

Autor: Vecchione A; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY., Jofra T; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Gerosa J; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Shankwitz K; Tissue Analysis Core, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Di Fonte R; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Galvani G; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ippolito E; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cicalese MP; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Schultz AR; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL., Seay HR; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL., Favellato M; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Milardi G; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Stabilini A; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ragogna F; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Grogan P; Department of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy.; TrialNet Clinical Center, IRCCS San Raffaele Hospital, Milan, Italy., Bianconi E; Department of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy.; TrialNet Clinical Center, IRCCS San Raffaele Hospital, Milan, Italy., Laurenzi A; Department of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy., Caretto A; Department of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy., Nano R; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Melzi R; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Danzl N; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY., Bosi E; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Department of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy.; TrialNet Clinical Center, IRCCS San Raffaele Hospital, Milan, Italy., Piemonti L; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Department of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy., Aiuti A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Brusko T; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL.; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL., Petrovas C; Tissue Analysis Core, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Battaglia M; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.; TrialNet Clinical Center, IRCCS San Raffaele Hospital, Milan, Italy., Fousteri G; Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy fousteri.georgia@hsr.it.

Publikováno v: Diabetes [Diabetes] 2021 Dec; Vol. 70 (12), pp. 2892-2902. Date of Electronic Publication: 2021 Oct 07.