Discovery and validation of novel human genomic safe harbor sites for gene and cell therapies

Autor: George M. Church, Sai T. Reddy, Alexander Yermanos, Edo Kapetanovic, Erik I. Aznauryan, Milanova D, Kinzina E

SummaryExisting approaches for the integration and expression of genes of interest in a desired human cellular context are marred by the safety concerns related to either the random nature of viral-mediated integration or unpredictable pattern of gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0a72286883211bc66a209717c872d79
https://doi.org/10.1101/2021.03.04.433856

MANAGEMENT OF CHANGE AND CHANGE OF MANAGEMENT.

Autor: Milanova, D.¹ dima9@abv.bg

Publikováno v: Trakia Journal of Sciences. 2010 Supplement 3, Vol. 8, p140-142. 3p.

An enhanced CRISPR repressor for targeted mammalian gene regulation.

Autor: Yeo NC; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Chavez A; Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA. ac4304@cumc.columbia.edu., Lance-Byrne A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA., Chan Y; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Menn D; School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering, Arizona State University, Tempe, AZ, USA., Milanova D; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Kuo CC; Department of Bioengineering, University of California, San Diego, San Diego, CA, USA.; Novo Nordisk Foundation Center for Biosustainability, University of California, San Diego, San Diego, CA, USA., Guo X; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Sharma S; Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge, UK., Tung A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA., Cecchi RJ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA., Tuttle M; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA., Pradhan S; School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering, Arizona State University, Tempe, AZ, USA., Lim ET; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Davidsohn N; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Ebrahimkhani MR; School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering, Arizona State University, Tempe, AZ, USA.; Division of Gastroenterology and Hematology, Mayo Clinic College of Medicine and Science, Phoenix, AZ, USA., Collins JJ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lewis NE; Department of Bioengineering, University of California, San Diego, San Diego, CA, USA.; Novo Nordisk Foundation Center for Biosustainability, University of California, San Diego, San Diego, CA, USA.; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA., Kiani S; School of Biological and Health Systems Engineering, Ira A. Fulton Schools of Engineering, Arizona State University, Tempe, AZ, USA. samira.Kiani@asu.edu., Church GM; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA. gchurch@genetics.med.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, MA, USA. gchurch@genetics.med.harvard.edu.

Publikováno v: Nature methods [Nat Methods] 2018 Aug; Vol. 15 (8), pp. 611-616. Date of Electronic Publication: 2018 Jul 16.

Sepsis Tanısı İçin Moleküler Yöntemlerdeki Yenilikler.

Autor: Özdemir, Yusuf Emre¹ dryusufeozdemir@gmail.com, Aygün, Gökhan²

Publikováno v: Klimik Journal / Klimik Dergisi. Jun2024, Vol. 37 Issue 2, p76-82. 7p.

Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen.

Autor: Tan, Wenfang Spring¹ (AUTHOR) inga.dry@roslin.ed.ac.uk, Rong, Enguang¹ (AUTHOR) paul.digard@roslin.ed.ac.uk, Dry, Inga¹ (AUTHOR) robert.dalziel@ed.ac.uk, Lillico, Simon^2,3 (AUTHOR) simon.lillico@roslin.ed.ac.uk, Law, Andy⁴ (AUTHOR) andy.law@roslin.ed.ac.uk, Digard, Paul¹ (AUTHOR), Whitelaw, Bruce^2,4 (AUTHOR) bruce.whitelaw@roslin.ed.ac.uk, Dalziel, Robert G.¹ (AUTHOR)

Publikováno v: Viruses (1999-4915). Feb2024, Vol. 16 Issue 2, p297. 22p.